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MetabolomicsContribution of fungal microbiome to intestinal physiology, early-life immune development and mucosal inflammation in mice
The gut microbiome consists of a multi-kingdom microbial community. Whilst the role of bacteria as causal contributors governing host physiological development is well established, the role of fungi remains to be determined. Here, we use germ-free mice colonized with defined species of bacteria, fun...
2022-01-14 | MTBLS1679 | MetaboLights
TranscriptomicsMicroRNA expression profiling during the life cycle of the silkworm (Bombyx mori)
Background: MicroRNAs (miRNAs) are expressed by a wide range of eukaryotic organisms, and function in diverse biological processes. Numerous miRNAs have been identified in Bombyx mori, but the temporal expression profiles of miRNAs corresponding to each stage transition over the entire life cycle of...
ORGANISM(S): Bombyx mori 
2010-02-20 | E-GEOD-18030 | biostudies-arrayexpress
MetabolomicsUntargeted serum metabolomics of early-life antibiotic intervention, fecal microbiota transplantation restoration, and short-term high-fat diet effects in C57BL/6 mice
This study profiles the serum metabolome in C57BL/6 mice subjected to early-life antibiotic treatment (vancomycin and gentamicin, 2 weeks), followed by fecal microbiota transplantation and a short-term high-fat diet. Serum samples were collected longitudinally and analyzed by liquid chromatography-t...
2026-08-20 | MTBLS14801 | MetaboLights
MetabolomicsInsights into the early-life chemical exposome of Nigerian infants and potential correlations with the developing gut microbiome

Early-life exposure to natural and synthetic chemicals can impact acute and chronic health conditions. Here, a suspect screening workflow anchored on high-resolution mass spectrometry was applied to elucidate xenobiotics in breast milk and matching stool samples collected from Nigerian mother-inf...

2025-08-07 | MTBLS8792 | MetaboLights
MetabolomicsPrenatal exposure to trace elements impacts mother-infant gut microbiome, metabolome and resistome during the first year of life

Infancy is a critical period for the colonization of the gut microbiome. However, xenobiotic effects on gut microbiome development in early life remain poorly understood. Here, we recruit 146 mother-infant pairs and collect stool samples at 3, 6, and 12 months after delivery for amplicon sequenci...

2025-05-02 | MTBLS11392 | MetaboLights
TranscriptomicsTranscriptome analysis of two life cycle stages of Trypanosoma brucei gambiense
Trypanosoma brucei gambiense is the causative agent of the fatal human disease African sleeping sickness. Here we have compared the transcriptome of two different life cycle stages, the potentially human-infective bloodstream form and the non-human-infective procyclic stage, using digital gene expre...
ORGANISM(S): Trypanosoma brucei gambiense 
2010-07-21 | E-GEOD-18065 | biostudies-arrayexpress
MetabolomicsMetabolomics Study On Bacterial Cellulose Biosynthesis In Komagataeibacter hansenii HDM1-3

To investigate the metabolic shift mechanism of Komagataeibacter hansenii(K. hansenii)HDM1-3 from the bacterial growth phase to the bacterial cellulose (BC) synthesis phase,untargeted metabolomics analysis was performed on K. hansenii HDM1-3 cultures at the early fermentation stage(18h) and ...

2025-12-29 | MTBLS13586 | MetaboLights
MetabolomicsProteolytic-Resistant Self-Assembling Peptide Nanofibers Combat Specific Bacterial Infections via Trap-and-Kill

The rise in global antibiotic resistance highlights the urgent need for effective antimicrobial agents. Antimicrobial peptides (AMPs) offer a potential solution to combat bacterial resistance. However, key challenges remain in addressing the limitations of current peptide drugs and biomaterials, ...

2025-06-13 | MTBLS12424 | MetaboLights
TranscriptomicsTranscriptomic effects of Ocean Acidification and their modulation by energy availability in the life-cycle stages of the coccolithophore Emiliania huxleyi
To investigate the effects of ocean acidification (OA) and their energy-dependent modulation in the life-cycle stages of E.huxleyi, diploid and haploid cells were acclimated to present and future CO2 partial pressures (pCO2; 38.5 Pa vs. 101.3 Pa CO2) under low and high light (50 vs. 300 M-5mol photo...
ORGANISM(S): Emiliania huxleyi 
2012-11-01 | E-MEXP-3624 | biostudies-arrayexpress
MetabolomicsAnalysis of 3274 bacterial isolates by rapid evaporative ionisation mass spectrometry (REIMS)

Analysis of bacterial composition using rapid evaporative ionisation mass spectrometry (REIMS) allows for the detection of metabolites that may be considered specific to particular taxons. This database of 3274 isolates covering gram positive and negative bacteria across 5 phyla, 12 classes, 24 o...

2025-06-13 | MTBLS10328 | MetaboLights
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