Sort   by:  
 Page size 
TranscriptomicsExpression data from BAP1 depleted cells
The deubiquitinase BAP1 is a candidate tumor suppressor regulating cell proliferation in human and is required for development in Drosophila. BAP1 is assembled into high molecular weight transcriptional multi-protein complexes. In order to identify potential BAP1 target genes, global mRNA expression...
ORGANISM(S): Homo sapiens 
2010-11-05 | E-GEOD-23035 | biostudies-arrayexpress
TranscriptomicsGene expression changes resulting from the stable loss of BAP1 in uveal melanoma cell lines
Uveal melanoma is a highly aggressive cancer with a strong propensity for metastasis, yet little is known about the biological mechanisms underlying this metastatic potential. We recently showed that most metastasizing uveal melanomas, which exhibit a class 2 gene expression profile, contain inactiv...
ORGANISM(S): Homo sapiens 
2013-09-06 | E-GEOD-48863 | biostudies-arrayexpress
GenomicsGenome wide binding sites of BAP1, HCF1 and OGT
We report the genome wide binding sites of BAP1, HCF1 and OGT in bone marrow derived macrophages. De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur in various malignancies. We show that mouse ...
ORGANISM(S): Mus musculus 
2012-11-07 | E-GEOD-40723 | biostudies-arrayexpress
TranscriptomicsGlobal expression analysis of BAP1 knockdown in transfected 92.1 cells
Analysis of the effect that reduced BAP1 levels have on global gene expression.The hypothesis tested was that reduction in BAP1 levels would produce changes in gene expression similar to changes observed in class 2 uveal melanomas. Data provided insight into genes that are disrupted with reduced BAP...
ORGANISM(S): Homo sapiens 
2011-01-06 | E-GEOD-24896 | biostudies-arrayexpress
ProteomicsIdentification of BRCA1-associated protein 1 (BAP1)-associated proteins
BRCA1-associated protein 1 (BAP1) is a multidomain deubiquitinase (DUB) with a ubiquitin carboxyl-terminal hydrolase (UCH) domain at its N-terminus. BAP1 mainly localizes in the nucleus and primarily functions as a transcriptional regulator in diverse cellular pathways, including cell proliferation...
ORGANISM(S): Homo sapiens (Human) 
2022-04-14 | PXD030044 | Pride
Human Bap1 Tumor suppressor Brca-1 associated protein 1 Deubiquitinase Dub 
TranscriptomicsDNA Copy-Number Alterations in clear-cell Renal Cell Carcinoma (ccRCC) Tumors and Tumorgrafts for samples deficient in BAP1 or PBRM1
Renal cell carcinoma (RCC) exhibits some unusual features and genes commonly mutated in cancer are rarely mutated in clear-cell RCC (ccRCC), the most common type. The most prevalent genetic alteration in ccRCC is the inactivation of the tumor suppressor gene VHL. Using whole-genome and exome sequenc...
ORGANISM(S): Homo sapiens 
2012-06-09 | E-GEOD-25540 | biostudies-arrayexpress
TranscriptomicsMolecular Genetic Classification of clear-cell Renal Cell Carcinoma (ccRCC) based on the Gene Expression Profiling of Tumors and Tumorgrafts deficient for BAP1 or PBRM1
Renal cell carcinoma (RCC) exhibits some unusual features and genes commonly mutated in cancer are rarely mutated in clear-cell RCC (ccRCC), the most common type. The most prevalent genetic alteration in ccRCC is the inactivation of the tumor suppressor gene VHL. Using whole-genome and exome sequenc...
ORGANISM(S): Homo sapiens 
2012-06-09 | E-GEOD-36895 | biostudies-arrayexpress
ProteomicsPervasive Roles of Ubiquitination in Orchestrating the Deubiquitinase Activity and Function of the BAP1/ASXL2 Tumor Suppressor Complex
The tumor suppressor and deubiquitinase (DUB) BAP1 regulates chromatin-associated processes and is frequently mutated in various malignancies. BAP1 and its drosophila orthologue Calypso assemble DUB complexes with ASXL-1, -2, -3 paralogues and ASX respectively, and these cofactors are required for s...
ORGANISM(S): Homo sapiens (Human) 
2018-09-28 | PXD011124 | Pride
Histone h2ak119ub  deubiquitination Polycomb group proteins  bap1  calypso  asxl  cell proliferation 
TranscriptomicsTranscriptome profiles of hematopoietic lineages from BAP1 WT and KO mice
BAP1 has been studied as a tumor suppressor. Our aim was to characterize genes that were altered in various hematopoietic cell types upon deletion of BAP1. BAP1 WT versus KO cells.
ORGANISM(S): Mus musculus 
2012-11-07 | E-GEOD-40541 | biostudies-arrayexpress
ProteomicsBAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation
In Drosophila, a complex consisting of Calypso and ASX catalyzes H2A deubiquitination and has been reported to act as part of the Polycomb machinery in transcriptional silencing. The mammalian homologs of these proteins (BAP1 and ASXL1/2/3, respectively), are frequently mutated in various cancer typ...
ORGANISM(S): Homo sapiens (Human) 
2019-01-28 | PXD011808 | Pride
Bap Asxl Prc1 
Sort   by:  
 Page size