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ProteomicsCharacterization of biofilm associated protein (Bap) in Staphylococcus xylosus
The biofilm associated protein (Bap) is recognised as the essential component for biofilm formation in Staphylococcus aureus V329 and other species. Although Bap orthologs are also present in most S. xylosus strains, their contribution to biofilm formation has not yet been determined. In this study,...
ORGANISM(S): Staphylococcus xylosus Bacteria 
2022-01-20 | PXD029728 | Pride
Staphylococcus xylosus Knockout Biofilm Bap Aggregation 
TranscriptomicsExpression data from human OC+BAP+ double positive versus OC-BAP- double negative cells
Subpopulation of circulating monocyte/macrophage lineage cells show a calcifying ability in vivo and in vitro. These cells may contribute to intimal calcification within atherosclerotic lesions and may have pathophysiological clinical and therapeutic implication in vascular disorders. Such cells exp...
ORGANISM(S): Homo sapiens 
2013-05-17 | E-GEOD-47060 | biostudies-arrayexpress
TranscriptomicsThalassiosira pseudonana exposure to benzopyrene BaP
Comparison of transcriptional profile of Thalassiosira pseudonana exposed for 24h to 36.45 ug/L BaP and methanol-treated controls. Four biological replicates (BaP treatment) and six biological replicates (controls).
ORGANISM(S): Thalassiosira pseudonana 
2012-02-15 | E-MEXP-3558 | biostudies-arrayexpress
TranscriptomicsReference: MicroRNA expression profiling in adult mouse liver following BaP treatment [Agilent miRNA array]
We have investigated the effect of exposure to 150 mg/kg benzo(a)pyrene (BaP) for 3 days on mRNA and miRNA expression levels in adult mouse liver. We used Agilent miRNA array platforms to assess effects of BaP exposure on miRNA expression levels. Our results indicate a distinct lack of effect of BaP...
ORGANISM(S): Mus musculus 
2010-10-28 | E-GEOD-19438 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by Benzo[a]pyrene (BaP) in human breast carcinoma cell line MCF-7 in different phases of the cell cycle
Benzo[a]pyrene (BaP) is a widespread environmental genotoxic carcinogen that damages DNA by forming adducts. This damage with along the activation of the aryl hydrocarbon receptor (AHR) induces complex transcriptional responses in cells. To investigate whether human cells are more susceptible to BaP...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-26917 | biostudies-arrayexpress
TranscriptomicsIntegration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells [BaP]
The use of integrated approaches in genetic toxicology, including the incorporation of gene expression data to determine the molecular pathways involved in the response, is becoming more common. In a companion paper, a genomic biomarker was developed in human TK6 cells to classify chemicals as genot...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-51172 | biostudies-arrayexpress
TranscriptomicsIntegration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells [BaP 8hr]
The use of integrated approaches in genetic toxicology, including the incorporation of gene expression data to determine the molecular pathways involved in the response, is becoming more common. In a companion paper, a genomic biomarker was developed in human TK6 cells to classify chemicals as genot...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-51173 | biostudies-arrayexpress
TranscriptomicsPulmonary gene and microRNA expression changes in mice exposed to benzo(a)pyrene by oral gavage
Polycyclic aromatic hydrocarbons (PAHs) are widely distributed, carcinogenic environmental contaminants produced as a consequence of the incomplete combustion of fossil fuels. Benzo[a]pyrene (BaP) is a very extensively studied prototypical PAH. We recently reported a complete lack of change in micro...
ORGANISM(S): Mus musculus 
2011-10-03 | E-GEOD-24751 | biostudies-arrayexpress
TranscriptomicsToxicogenomics and phenotypic characterization of adult male zebrafish liver treated with benzo-[A]-pyrene (BAP)
We performed microarray-based expression profiling on liver of male zebrafish exposed to 5, 50, and 500 µg/L of benzo-[A]-pyrene (BAP) for 24 and 96 hours, to identify global transcriptional programs and biological pathways involved in BAP-induced adaptive responses under in vivo environment. We ana...
ORGANISM(S): Danio rerio 
2012-01-01 | E-GEOD-30035 | biostudies-arrayexpress
ProteomicsDevelopment of a method for quantitative analysis of in vivo interactions of pluripotency transcription factors Sox2, Oct4, Nanog by mass spectrometry
Protein-protein proximity of core pluripotency transcription factors plays an important role during cell reprogramming. Pluripotent embryonic stem (ES) cell identity is controlled by a trio of transcription factors: Sox2, Oct4, and Nanog. These proteins often bind to closely localized genomic sites....
ORGANISM(S): Homo sapiens (Human) 
2020-01-21 | PXD015756 | Pride
Mass spectrometry Oct4 Proximity utilizing biotinylation Transcription factors Sox2 Pluripotency 
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