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MetabolomicsBacteroides uniformis degrades β-glucan to promote Lactobacillus johnsonii improving indole-3-lactic acid levels in alleviating colitis

The gut microbiota plays a crucial role in the onset and progression of inflammatory bowel disease (IBD). β-glucan (BG), a soluble dietary fiber widely present in oats, barley, fungi, yeast and some bacteria, has multiple bioactive properties such as mitigating intestinal inflammation; however, t...

2024-02-12 | MTBLS8950 | MetaboLights
Proteomicsβ-1,3-glucan recognition by Acanthamoeba castellanii as a putative mechanism of amoeba-fungal interactions
Acanthamoeba castellanii (Ac) and macrophages share structural, morphological, physiological and biochemical similarities, including the ability to phagocyte a myriad of microorganisms in the environments they live. Whereas there is voluminous information on phagocytic receptors of macrophages, for ...
ORGANISM(S): Acanthamoeba castellanii 
2022-12-02 | PXD028907 | Pride
Macrophage Β-glucan Histoplasma capsulatum Acanthamoeba. castellanii Interaction Dectin 
TranscriptomicsBeta-glucan is a major growth substrate for human gut bacteria related to Coprococcus eutactus
The gut bacterium Coprococcus sp. ART55/1 has been found to encode two genes containing glycoside hydrolase family 9 (GH9) catalytic domains. These genes are hypothesised to impact upon the ability of this bacteria to utilise different carbon sources. To further investigate the role of these genes, ...
ORGANISM(S): Coprococcus sp. ART55/1 
2020-03-09 | E-MTAB-8048 | biostudies-arrayexpress
ProteomicsBeta-glucan is a major growth substrate for human gut bacteria related to Coprococcus eutactus
A clone encoding carboxymethylcellulase activity was isolated during functional screening of a human gut metagenomic library using Lactococcus lactis MG1363 as heterologous host. The insert sequence revealed a glycoside hydrolase family 9 (GH9) catalytic domain with sequence similarity to a gene fro...
ORGANISM(S): Coprococcus sp. ART55/1 
2020-03-10 | PXD014174 | Pride
Coprococcus eutactus  beta-glucan 
TranscriptomicsThe role of HIF-1 in beta-glucan induced response in myeloid cell
beta-glucan induced glycolysis in HIF-1 depedent manner. We reported that beta-glucan injection in mice led to upregulated glycolysis. HIF-1a plays a major role in this process. Mice receives beta-glucan via ip for 4 days. Splenocytes were isolated for RNA sequencing.
ORGANISM(S): Mus musculus 
2014-09-26 | E-GEOD-57206 | biostudies-arrayexpress
ProteomicsProteomic analysis reveals enzymes for β-D-glucan formation and degradation in Levilactobacillus brevis TMW 1.2112
Bacterial exopolysaccharide (EPS) formation is crucial for biofilm formation, protection against environmental factors or as storage compounds. EPSs produced by lactic acid bacteria (LAB) are appropriate for applications in food fermentation or the pharmaceutical industry, yet the dynam-ics of forma...
ORGANISM(S): Levilactobacillus brevis 
2022-03-21 | PXD031809 | Pride
Moonlighting proteins Glycosyl hydrolase Β-glucan Exopolysaccharide Levilactobacillus brevis tmw 1.2112 Glycosyltransferase Proteome Secretome 
TranscriptomicsGenome-wide transcriptome analysis of maize (Zea mays c.v. Nathan) plants infected by Colletotrichum graminicola strains.
In order to characterize defense responses not only cytologically, but also on the transcript level, genome-wide sequencing of mRNA isolated from non-infected control leaves and from leaves inoculated either with the WT or with GLS1 overexpressing strains was performed, using Illumina Next Generatio...
ORGANISM(S): Zea mays 
2013-06-25 | E-GEOD-48208 | biostudies-arrayexpress
GenomicsCandida albicans induces monocyte training via epigenetic programming through a dectin 1-dependent pathway
Non-specific protective effects against reinfection have been described following infection with Candida albicans. Here we show that mice defective in functional T and B lymphocytes were protected against reinfection with C. albicans in a monocyte-dependent manner. C. albicans and beta glucans induc...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-34260 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse MyD88-deficient bone marrow-derived macrophages treated with Zymosan
Innate immune pattern recognition receptors play critical roles in pathogen detection and initiation of antimicrobial responses. We and others have previously demonstrated the importance of the beta-glucan receptor Dectin-1 in the recognition of pathogenic fungi by macrophages and dendritic cells, a...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6376 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of extracellular vesicles released from human primary macrophages upon beta/glucan stimulation
Fungal infections (mycoses) are common diseases of varying severity that cause problems especially to immunologically compromised people. During stimulatory conditions of infection and colonization, besides intensive intracellular response, human cells actively communicate on the intercellular lev...
ORGANISM(S): Homo sapiens (Human) 
2014-04-15 | PXD000642 | Pride
Extracellular vesicles Human primary macrophages Itraq-labeling Lc-ms/ms 
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