bone development

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Tissue

Bone marrow (37)
Blood (12)
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Bone (8)
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B cell (7)
Brain (7)
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Normotensive (1)
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Perilobar nephrogenic rest (1)
Oropharynx squamous-cell carcinoma in DiseaseLocation oropharynx has DiseaseStaging lymph node negative (N0) (1)
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Mass Spectrometry (127)
Mass spectrometry (102)
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NextSeq 500, Illumina HiSeq 4000, ILLUMINA (1)
Combined on identical nucleotide universal identifier, Illumina HumanWG-6 version 3 or Illumina HumanHT-12 expression bead chip (1)
ILLUMINA, NextSeq 500 (1)
Affymetrix OncoScan FFPE Express (1)
Illumina HumanCoreExome-12v1-0, Illumina HumanCoreExome-12v1-1, Illumina HumanCoreExome-24v1-0 (1)
Illumina HiSeq 2500, ILLUMINA (1)
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Instrument Platform

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NA (6)
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UNIPROT ID/AC

1433E_SHEEP (6)
1433Z_SHEEP (6)
6PGD_SHEEP (6)
A1AT_SHEEP (6)
A8DR93_SHEEP (6)
AL1A1_SHEEP (6)
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ANT3_SHEEP (6)
ANXA2_SHEEP (6)
CERU_SHEEP (6)
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FETUA_SHEEP (6)
G3P_SHEEP (6)
HBB_SHEEP (6)
IDHC_SHEEP (6)
PDXK_SHEEP (6)
PLMN_SHEEP (6)
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W5NUX8_SHEEP (6)
W5NVC9_SHEEP (6)
W5NXN2_SHEEP (6)
W5NY95_SHEEP (6)
W5NYA7_SHEEP (6)
W5P1X9_SHEEP (6)

ENSEMBL ID

ENSMUSG00000021039 (1)
ENSMUSG00000027651 (1)
ENSMUSP00000141097 (1)

CHEBI ID

CHEBI:16737 (21)
CHEBI:15891 (19)
CHEBI:16704 (18)
CHEBI:17368 (18)
CHEBI:30769 (18)
CHEBI:16708 (17)
CHEBI:15428 (17)
CHEBI:30915 (17)
CHEBI:16919 (17)
CHEBI:17596 (17)
CHEBI:18211 (16)
CHEBI:17562 (16)
CHEBI:17154 (16)
CHEBI:16335 (16)
CHEBI:18107 (15)
CHEBI:18257 (15)
CHEBI:7916 (15)
CHEBI:16610 (14)
CHEBI:28044 (14)
CHEBI:43355 (14)
CHEBI:17750 (14)
CHEBI:37024 (14)
CHEBI:15971 (14)
CHEBI:17568 (14)
CHEBI:16015 (14)
CHEBI:16750 (14)
CHEBI:16027 (14)
CHEBI:49033 (13)
CHEBI:16359 (13)
CHEBI:6650 (13)

Metabolite Name

Hypoxanthine (25)
L-Histidine (24)
Creatine (24)
Taurine (23)
Adenine (22)
Creatinine (22)
Inosine (22)
Adenosine (21)
Choline (20)
L-Tryptophan (20)
Uracil (19)
Uric acid (19)
L-Phenylalanine (19)
Spermidine (18)
Glycerophosphocholine (18)
Thymine (17)
Kynurenic acid (17)
Riboflavin (17)
Cytidine (17)
Xanthine (17)
L-Tyrosine (17)
Thiamine (16)
Citrulline (16)
Indole (16)
L-Lysine (16)
Citric acid (16)
L-Glutamine (16)
Azelaic acid (16)
Betaine (15)
Pyroglutamic acid (15)

First Public Date

2025 (286)
2014 (276)
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2022 (165)
2020 (150)
2021 (126)
2019 (96)
2018 (88)
2015 (74)
2017 (71)
2016 (51)
2013 (28)
2012 (1)
2011 (1)

Modelling Approach

Ordinary differential equation model (6)
Finite element spatial model (1)
Partial differential equation model (1)

Study status

Completed (1)

Lab affiliation

Institute for Research in Immunology and Cancer, Department of Biochemistry, Department of Chemistry, Université de Montréal, Québec, Canada H3T 1J4 (4)
Department of Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada; Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada; The Hotchkiss Brain Institute, University of Calgary, Alberta, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, Alberta, Canada (3)
Vetsuisse Faculty (VET), Department of Molecular Mechanisms of Disease, University of Zurich (UZH) (3)
1) Department Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; 2) Institute for Bioanalysis, University of Applied Science Coburg, Coburg, Germany (2)
Department of Chemistry & Chemical Biology, Northeastern University (2)
1 The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark 2 Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark 4 Novo Nordisk Foundation Center for Stem Cell Biology, DanStem, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark (1)
1Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China 2The Third School of Clinical Medicine, Southern Medical University, Guangzhou, China (1)
Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China (1)
Affiliation* Key Laboratory of Genetics and Breeding, Zhejiang Institute of Freshwater Fisheries, Huzhou, China (1)
Assistant Professor of Medicine Department of Medicine Tulane University School of Medicine 1430 Tulane Avenue, New Orleans, LA,70114 (1)
Basic Research Lab for “Epigenetic Regeneration of Aged Skeleto-Muscular System (ERASMUS)”, Department of Molecular Genetics and Dental Pharmacology, School of Dentistry, Dental Research Institute, Seoul National University, Seoul, South Korea (1)
Center for Translational and Clinical Research, Department of Proteomics, School of Medicine, University of Zagreb, Zagreb, Croatia Drago Perović Department of Anatomy, School of Medicine, University of Zagreb, Zagreb, Croatia (1)
Center of Excellence in Systems Biology, Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand (1)
Centre for Cancer Evolution Barts Cancer Institute Queen Mary University of London John Vane Science Centre Charterhouse square London EC1M 6BQ (1)
Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London (1)
Centre for Oncology, Radiopharmaceuticals and Research, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, K1A 0K9, Canada (1)
Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany Bavarian Center for Biomolecular Mass Spectrometry, Freising, Germany (1)
Conway Institute, School of Medicine, University College Dublin, Ireland (1)
DKFZ - German Cancer Research Center, “Division of Virus-Associated Carcinogenesis”, Im NeuenheimerFeld 280, 69120 Heidelberg, Germany (1)
Department Chair • MCG - Department of Cellular Biology & Anatomy, Augusta University (1)
Department of Biochemistry and Functional Genomic, Université de Sherbrooke, QC, Canada (1)
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha NE (1)
Department of Biochemistry and Structural Biology, UT Health San Antonio, San Antonio, TX 78922 (1)
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA (1)
Department of Biomedical Science, University of Copenhagen, Denmark (1)
Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, USA (1)
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA (1)
Department of Genetics, Cell Biology, & Anatomy Buckley Lab University of Nebraska Medical Center Omaha, Nebraska United States of America (1)
Department of Hematopoiesis, Sanquin Research, Amsterdam, The Netherlands (1)
Department of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, and 2Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden (1)

Keyword

Patients with metastatic colorectal cancer who did not receive (1)
Systemic treatment for their metastatic disease (1)
Capecitabine (1)
Irinotecan (1)
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Oxaliplatin (1)

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fungi (2)
protozoa (1)
bacteria (1)

Study type

Transcription profiling by array (3852)
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Unknown experiment type (190)
Comparative genomic hybridization by array (161)
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2002 (20)
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1997 (5)

Location

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Strontium chelate with Achyranthes bidentata polysaccharide as a carrier promotes bone regeneration through mediating gut-liver-bone axis: The TD chicken model

This study investigates the effect of Achyranthes bidentata polysaccharide-strontium (ABPS-Sr) chelate on tibial dyschondroplasia (TD) in broilers and its underlying mechanisms. TD is a prevalent leg disorder in commercial broilers characterized by reduced angiogenesis in the tibial growth plate ...

2025-09-25 | MTBLS13045 | MetaboLights

Strontium chelate with Achyranthes bidentata polysaccharide as a carrier promotes bone regeneration through mediating gut-liver-bone axis: The TD chicken model

2025-09-24 | MTBLS13038 | MetaboLights

Alcohol-Induced Bone Loss: Driven by Dysregulated Spatial Distribution of Gut Microbiota and PGD2-IL17 Pathway-Mediated Osteoclast Activation

Purpose: Alcohol-induced damage to bone microstructure leads to alcoholic osteopenia (AOP). While prior studies have demonstrated alcohol's negative impact on bone density, the mechanisms by which alcohol induces osteoporosis through immune pathways, gut microbiota dysbiosis, and metabolic altera...

2025-03-28 | MTBLS11887 | MetaboLights

Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation

Mechanical force is critical for the development and remodeling of bone. Here we report that mechanical force regulates the production of the metabolite asymmetric dimethylarginine (ADMA) via regulating the hydrolytic enzyme dimethylarginine dimethylaminohydrolase 1 (Ddah1) expression in osteobla...

2021-11-23 | MTBLS3725 | MetaboLights

Contribution of fungal microbiome to intestinal physiology, early-life immune development and mucosal inflammation in mice

The gut microbiome consists of a multi-kingdom microbial community. Whilst the role of bacteria as causal contributors governing host physiological development is well established, the role of fungi remains to be determined. Here, we use germ-free mice colonized with defined species of bacteria, fun...

2022-01-14 | MTBLS1679 | MetaboLights

Multi-omics Insights into Postnatal Skeletal Muscle Development in Duroc Pigs

Skeletal muscles, accounting for 40% of mammalian body mass, exhibit pronounced heterogeneity due to distinct anatomical locations. Animal husbandry excessively focuses on longissimus dorsi (LDM) development, while neglecting other muscles. In this study, we integrated Bulk RNA Sequencing (bulk R...

2025-09-09 | MTBLS12963 | MetaboLights

T cell acute leukaemia development and chemo-resistance are mediated by dynamic interactions with heterogeneous bone marrow microenvironments.

It is widely accepted that complex interactions between cancer cells and their surrounding microenvironment contribute to disease development, chemo-resistance and disease relapse. In light of this observed interdependency, novel therapeutic interventions that target specific cancer stroma cell line...

ORGANISM(S): Homo sapiens

2016-07-01 | E-MTAB-4889 | biostudies-arrayexpress

A Novel Method for Isolating Whole Protein from Human Cranial Bone

The presence of the extracellular matrix within human bone limits the applicability of conventional protocols for protein extraction. As a result, complete and accurate characterization of human bone proteome is yet to be performed, and as a result, several bone-related diseases such as craniosynost...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2017-03-28 | MSV000080697 | MassIVE

Transcription profiling of human bone marrow derived and trabecular bone osteogenic cells - 0

This SuperSeries is composed of the following subset Series:; GSE12264: Gene Expression Profile of Osteogenic Cells Derived from Human Bone Marrow and Trabecular Bone I; GSE12265: Gene Expression Profile of Osteogenic Cells Derived from Human Bone Marrow and Trabecular Bone II; GSE12266: Gene Expres...

ORGANISM(S): Homo sapiens

2008-10-21 | E-GEOD-12267 | biostudies-arrayexpress

Integrated transcriptomic and proteomic analysis reveals Runx2b-associated molecular regulation of intermuscular bone development in Culter alburnus

This dataset contains LC-MS/MS-based proteomic data generated from muscle/myoseptal tissues of wild-type, heterozygous runx2b mutant, and homozygous runx2b mutant Culter alburnus individuals. The study aimed to characterize proteomic changes associated with runx2b-mediated intermuscular bone reducti...

ORGANISM(S): Culter alburnus

2026-09-07 | PXD080591 | Pride

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