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TranscriptomicsTranscription profiling of mouse brain region bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum to identify distinct transcriptional patterns.
To identify distinct transcriptional patterns between the major subcortical dopamine targets commonly studied in addiction we studied differences in gene expression between the bed nucleus of the stria terminalis (BNST), nucleus accumbens (NAc), and dorsal striatum (dStr) using microarray analysis. ...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5763 | biostudies-arrayexpress
TranscriptomicsTranscriptional interaction network analyses in dorsal nucleus of vagus nerve, locus coeruleus and substantia nigra in Parkinson's disease
We analyzed the transcriptomic profile of post-mortem explants from dorsal nucleus of vagus nerve, locus coeruleus and substantia nigra obtained from controls and Braak 4 (BK4) and 5 (BK5) stages of Parkinson’s disease (PD) patients in order to investigate how gene-gene interaction patterns vary alo...
ORGANISM(S): Homo sapiens 
2015-01-11 | E-GEOD-43490 | biostudies-arrayexpress
GenomicsBAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli
ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models of several psychiatric disorders. Here, we demonstrate that Baz1b, an accessory subunit of the ISWI family of chromatin remodeling complexes, is upregulated in the n...
ORGANISM(S): Mus musculus 
2016-07-30 | E-GEOD-85005 | biostudies-arrayexpress
ProteomicsShotgun analysis of nuclear proteins from mouse brain
Nuclei were isolated from the mouse brain. Proteins were extracted with addition of Bensonase and cleaned up by acetone precipitation. Proteis were resuspended in 50 mM ammonium bicarbonate and PPS Silent Surfactant. Samples were sonicated on ice to improve the solubility of proteins, then alkylated...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000079301 | MassIVE
TranscriptomicsTranscription profiling by high throughput sequencing of methamphetamine-sensitized and saline-control mouse nucleus accumbens
Using ssRNA-seq, we examined the alteration of transcription profiles in the nucleus accumbens of methamphetamine-sensitized mice. Methamphetamine was a commonly abused psychostimulant. Repeated exposure to methamphetamine elicited long-lasting cellular and molecular changes, including the aberrant ...
ORGANISM(S): Mus musculus 
2017-01-15 | E-MTAB-2843 | biostudies-arrayexpress
TranscriptomicsExpression profiling in dopaminergic brain structures of rats self-administering cocaine
Gene expression profiling in dopaminergic brain structures of rats self-administering cocaine. Effect of histone deacetylase inhibition We have shown that injection of the HDAC inhibitor trichostatin A (TsA) to rats is sufficient to decrease their motivation to self-administer cocaine. The aim of th...
ORGANISM(S): Rattus norvegicus 
2010-01-21 | E-GEOD-18055 | biostudies-arrayexpress
TranscriptomicsGenes associated with alcohol abuse and nicotine addiction in the human nucleus accumbens
Background: The incidence of alcohol and tobacco co-abuse is as high as 80%. The molecular mechanism underlying this comorbidity is virtually unknown but interactions between these drugs have important implications for the development of, and recovery from drug dependence. Methods: We investigat...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-20568 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of the osmotic and reproductive remodelling of the female rat supraoptic nucleus
The supraoptic nucleus (SON) of the hypothalamus is an important integrative brain structure that co-ordinates responses to perturbations in water balance and regulates maternal physiology through the release of the neuropeptide hormones vasopressin and oxytocin into the circulation. Both dehydratio...
ORGANISM(S): Rattus norvegicus 
2011-12-29 | E-GEOD-30733 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and chimp brain tissues
We have analyzed gene expression in various brain regions of humans and chimpanzees. Within both human and chimpanzee individuals, the transcriptomes of the cerebral cortex are very similar to each other and differ more between individuals than among regions within an individual. In contrast, the tr...
ORGANISM(S): Homo sapiens 
2010-02-12 | E-AFMX-2 | biostudies-arrayexpress
TranscriptomicsComparative microarray analyses between the rat superior olivary complex and the brain
To investigate the participation of deafness genes in the genetic program of the superior olivary complex (SOC), a prominent auditory brainstem center, we performed a comparative genome-wide microarray based gene expression analysis of the rat SOC and the rat brain at postnatal days (P) P4 and P25. ...
ORGANISM(S): Rattus norvegicus 
2013-07-31 | E-GEOD-16764 | biostudies-arrayexpress
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