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ProteomicsEssential role of NLRC5 in cancer immune surveillance and cancer immunoediting
Background/Objectives: Downregulation of NLRC5, the transcriptional activator of MHC class-I, results in tumor immune evasion via escape from CD8+ T cell-mediated tumor control. As NLRC5 deficiency does not abrogate CD8+ T cell development, we investigated whether NLRC5-dependent antitumor immune me...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-19 | PXD060523 | Pride
Cancer immune surveillance  cancer immunoediting  nlrc5  mhc class-i  3-methylcholanthrene  cytolytic t lymphocyte  granzyme 
GenomicsMetastatic immunoediting in breast cancer cells
Metastatic immunoediting in breast cancer cells
PRJNA1081861 | ENA
TranscriptomicsDNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapy
Cancers evade the immune system in order to grow or metastasise through the process of cancer immunoediting. While checkpoint inhibitor therapy has been effective for reactivating tumour immunity in some cancers, many solid cancers, including breast cancer, remain largely non-responsive. Understandi...
ORGANISM(S): Mus musculus 
2021-09-01 | E-MTAB-10027 | biostudies-arrayexpress
ProteomicsTumour cells can escape antiproliferative pressure by type I interferon through immunoediting of interferon receptor expression
Type I interferons (IFNs) play a central role in innate immunity against virus infection, but also in the antitumour response. In tumour biology, an important mechanism of action apart from the more indirect immune-modulatory and anti-angiogenic effects of IFNs, is their direct impact on cell prolif...
ORGANISM(S): Homo sapiens (Human) 
2023-11-21 | PXD043761 | Pride
Interferon signalling Immunoediting Cell proliferation Tumour evolution Liver cancer 
UnknownNovel strategies for cancer immunotherapy: counter-immunoediting therapy.
Not available
S-EPMC10099030 | biostudies-literature
UnknownDNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and immunotherapy response.
Not available
S-EPMC9640547 | biostudies-literature
GenomicsDNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapy
DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapy
PRJEB42702 | ENA
UnknownImmunogenomic pan-cancer landscape reveals immune escape mechanisms and immunoediting histories.
Not available
S-EPMC8333422 | biostudies-literature
UnknownImmunosurveillance and Immunoediting of Lung Cancer: Current Perspectives and Challenges.
Not available
S-EPMC7014343 | biostudies-literature
UnknownNeoantigen quality predicts immunoediting in survivors of pancreatic cancer.
Not available
S-EPMC9177421 | biostudies-literature
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