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Background/Objectives: Downregulation of NLRC5, the transcriptional activator of MHC class-I, results in tumor immune evasion via escape from CD8+ T cell-mediated tumor control. As NLRC5 deficiency does not abrogate CD8+ T cell development, we investigated whether NLRC5-dependent antitumor immune me...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-19 | PXD060523 | Pride
Metastatic immunoediting in breast cancer cells
Type I interferons (IFNs) play a central role in innate immunity against virus infection, but also in the antitumour response. In tumour biology, an important mechanism of action apart from the more indirect immune-modulatory and anti-angiogenic effects of IFNs, is their direct impact on cell prolif...
ORGANISM(S): Homo sapiens (Human) 
2023-11-21 | PXD043761 | Pride
Cancers evade the immune system in order to grow or metastasise through the process of cancer immunoediting. While checkpoint inhibitor therapy has been effective for reactivating tumour immunity in some cancers, many solid cancers, including breast cancer, remain largely non-responsive. Understandi...
ORGANISM(S): Mus musculus 
Immunoediting instructs tumor metabolic reprogramming to support immune evasion [smartseq]
Immunoediting instructs tumor metabolic reprogramming to support immune evasion [ExomeSeq]
Mechanisms of immunoediting and immune evasion in MLL-AF9 AML.
Immunoediting instructs tumor metabolic reprogramming to support immune evasion [RNA-seq]
Immunoediting instructs tumor metabolic reprogramming to support immune evasion [Bisulfite-seq]
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