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ProteomicsCRISPR-Assisted Detection of RNA-Protein Interactions in Living Cells
We develop a CRISPR-Assisted RNA-Protein Interaction Detection method (CARPID), which leverages CRISPR/CasRx-based RNA targeting and proximity labeling to identify binding proteins of specific lncRNA in the native cellular context.
ORGANISM(S): Homo Sapiens 
2020-05-20 | PXD015702 |
TranscriptomicsCRISPR-Assisted Detection of RNA-Protein Interactions in Living Cells
Delineating the protein network associated with long non-coding RNAs (lncRNAs) is fundamental to understanding the functional mechanisms of lncRNAs. Current methods to identify lncRNA binding proteins either rely on crosslinking mediated complex co-precipitation or require extensive molecular engine...
ORGANISM(S): Mus musculus musculus x Mus musculus castaneus Homo sapiens 
2020-06-21 | GSE137556 | GEO
ProteomicsCRISPR-assisted RNA-protein interaction detection (CARPID) combined with quantitative mass spectrometry was used to identify proteins interacting with the long non-coding RNA (lncRNA) Taurine Up-regulated 1 (TUG1) in HEK293T cells under physiological conditions and after Camptothecin (CPT) treatment.
This project utilized CRISPR-assisted RNA-protein interaction detection (CARPID) combined with mass spectrometry to identify proteins interacting with the long non-coding RNA (lncRNA) TUG1 in HEK293T cells. TUG1 preferentially interacts with known R-loop-associated proteins, particularly under Campt...
ORGANISM(S): Homo Sapiens (human) 
2025-07-17 | PXD049137 | JPOST Repository
GenomicsCRISPR-Assisted Detection of RNA-Protein Interactions in Living Cells
CRISPR-Assisted Detection of RNA-Protein Interactions in Living Cells
PRJNA565917 | ENA
UnknownComprehensive identification of proteins interacting with long non-coding RNA TUG1 in R-loop regulation.
Not available
S-EPMC12480733 | biostudies-literature
ProteomicsLncRNA LETS1 promotes TGF--induced EMT and cancer progression
Transforming growth factor- (TGF-) signaling is a critical driver of epithelial–mesenchymal transition (EMT) and cancer progression. However, the regulatory roles of long non-coding RNAs (lncRNAs) in TGF--induced EMT and cancer progression are not well understood. Here, we identified an unannotated ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-31 | PXD037401 | Pride
Lncrna  tfg-beta  cancer  emt 
ProteomicsTargeting PURPL RNA Enabled Rejuvenation of Senescence Cells via Epigenetic Reprogramming
Cellular senescence is a fundamental driver of ageing and age-related diseases, characterized by irreversible growth arrest and profound epigenetic alterations. While long non-coding RNAs (lncRNAs) have emerged as key regulators of senescence, their potential for senescent cell rejuvenation remains ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD068664 | Pride
Purpl  rna binding protein  carpid 
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