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TranscriptomicsEarly and late passage endothelial cells with or without PDCD10 downregulation
Primary cells deficient for PDCD10/CCM3 do not enter senescence as control cells. Microarray analysis was performed in cells transduced with non-targeting shRNA and CCM3 shRNA at passage 7 (early passage) and passage 11 (late passage), when control cells are already senescent. Primary endothelial ce...
ORGANISM(S): Homo sapiens 
2014-04-10 | E-GEOD-54095 | biostudies-arrayexpress
GenomicsmRNA expression changes in CCM3-deficient endothelial cells
mRNA expression changes in CCM3-deficient endothelial cells
PRJNA565417 | ENA
GenomicsCRISPR/Cas9 genome editing demonstrates that CCM3 modulates endothelial miRNA expression
CRISPR/Cas9 genome editing demonstrates that CCM3 modulates endothelial miRNA expression
PRJNA473162 | ENA
GenomicsCCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling
CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling
PRJNA655226 | ENA
GenomicsCRISPR/Cas9 genome editing demonstrates that CCM3 modulates endothelial miRNA expression
CCM3 regulates blood-brain-barrier integrity and vascular maturation in vivo. CCM3 loss-of-function variants predispose to cerebral cavernous malformations (CCM). Various signalling pathways are deregulated upon CCM3 depletion in endothelial cells (ECs). In this study, we established a crRNA:tracrRN...
ORGANISM(S): Homo sapiens 
2019-01-18 | GSE114947 | GEO
UnknownPDCD10 (CCM3) regulates brain endothelial barrier integrity in cerebral cavernous malformation type 3: role of CCM3-ERK1/2-cortactin cross-talk.
Not available
S-EPMC4618087 | biostudies-literature
GenomicsRNA-seq of wild-type and Ccm3 knock-out mouse cerebellar endothelial cells
RNA-seq of wild-type and Ccm3 knock-out mouse cerebellar endothelial cells
PRJNA873291 | ENA
ProteomicsNDR kinase Tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development
The GckIII pathway is a Hippo-like kinase module defined by sequential activation of Ste20 kinases Thousand and One (Tao) and Germinal Center Kinase III (GckIII), followed by nuclear dbf2-related (NDR) kinase Tricornered (Trc). We previously uncovered a role for the GckIII pathway in regulating tube...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-03-13 | PXD038912 | Pride
Trachea Drosophila Ndr kinase Tricornered 
TranscriptomicsmRNA expression changes in CCM3-deficient endothelial cells
Loss-of-function variants in CCM3/PDCD10 predispose to cerebral cavernous malformations (CCMs) that are vascular lesion of the central nervous system. Using CRISPR/Cas9 genome editing and RNA sequencing, we have shown that long-term inactivation of CCM3 in human endothelial cells dysregulates fibron...
ORGANISM(S): Homo sapiens 
2020-07-06 | GSE137425 | GEO
UnknownBiallelic CCM3 mutations cause a clonogenic survival advantage and endothelial cell stiffening.
Not available
S-EPMC6378188 | biostudies-literature
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