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TranscriptomicsThe matricellular protein CCN1 activates a pro-inflammatory genetic program in murine macrophages
Effects of the matricellular protein CCN1 on macrophage inflammatory gene expression was tested in a macrophage cell line I-13.35. CCN1 (CYR61) is a matricellular protein that is highly expressed at sites of inflammation and wound repair. In these contexts, CCN1 can modify the activities of specifi...
ORGANISM(S): Mus musculus 
2010-05-14 | E-GEOD-19731 | biostudies-arrayexpress
ProteomicsTumor matrix stiffness induces CCN1/CYR61 upregulation of N-Cadherin to promote cancer cell trans-endothelial migration and metastasis
Tumor progression is often accompanied with increased extracellular matrix stiffness, but how this affects endothelial cells (ECs) is largely unknown. We used mass spectrometry to analyse the proteomic changes of primary human ECs cultured on physiological or tumor stiffness and found that CCN1/CYR6...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD003316 | Pride
Stiffness  protome  silac  ccn1  matrigel  huvec  tumour  vasculature 
GenomicsAstrocyte CCN1 stabilizes neural circuits in the adult brain
Astrocyte CCN1 stabilizes neural circuits in the adult brain
PRJNA1271423 | ENA
GenomicsInjured tubule-derived CCN1 exacerbates renal congestion-mediated acute kidney injury and fibrosis
Injured tubule-derived CCN1 exacerbates renal congestion-mediated acute kidney injury and fibrosis
PRJNA1195921 | ENA
TranscriptomicsAstrocyte CCN1 stabilizes neural circuits in the adult brain
We have used single-nucleus (sn) RNA sequencing through a 10x Genomics platform to examine the impact of overexpressing CCN1 in astrocytes during the critical period. We transcriptionally profiled all cell types in the visual cortex after bilateral injection AAV-CCN1 or AAV-tdTomato as a control.
ORGANISM(S): Mus musculus 
2025-09-18 | GSE298814 | GEO
UnknownCCN1 Regulates Chondrocyte Maturation and Cartilage Development.
Not available
S-EPMC4822413 | biostudies-literature
TranscriptomicsThe matricellular protein CCN1 activates a pro-inflammatory genetic program in murine macrophages
Effects of the matricellular protein CCN1 on macrophage inflammatory gene expression was tested in a macrophage cell line I-13.35. CCN1 (CYR61) is a matricellular protein that is highly expressed at sites of inflammation and wound repair. In these contexts, CCN1 can modify the activities of specific...
ORGANISM(S): Mus musculus 
2010-02-18 | GSE19731 | GEO
UnknownValproic Acid-Induced CCN1 Promotes Osteogenic Differentiation by Increasing CCN1 Protein Stability through HDAC1 Inhibition in Tonsil-Derived Mesenchymal Stem Cells.
Not available
S-EPMC8834451 | biostudies-literature
GenomicsGlucose metabolism influences the adaptive response of osteocytes to mechanical stimuli via CCN1
Glucose metabolism influences the adaptive response of osteocytes to mechanical stimuli via CCN1
PRJNA898298 | ENA
TranscriptomicsInjured tubule-derived CCN1 exacerbates renal congestion-mediated acute kidney injury and fibrosis
Epidemiological studies showed that patients with heart failure frequently develop kidney dysfunction, called cardio-renal syndrome (CRS). Elevated central venous pressure rather than low cardiac output strongly correlates with worsening renal function, and is being increasingly recognized as the pa...
ORGANISM(S): Mus musculus 
2025-07-09 | GSE283859 | GEO
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