Sort   by:  
 Page size 
GenomicsGenetic Framework for GATA Factor Function in Vascular Biology
Vascular endothelial dysfunction underlies the genesis and progression of numerous diseases. Whereas the GATA transcription factor GATA-2 is expressed in endothelial cells and is implicated in coronary heart disease, it has been studied predominantly as a master regulator of hematopoiesis. As many q...
ORGANISM(S): Homo sapiens 
2011-08-11 | E-GEOD-29531 | biostudies-arrayexpress
ProteomicsA quantitative proteomic analysis of in vitro assembled chromatin
The structure of chromatin is critical for many aspects of cellular physiology and is considered to be the primary medium to store epigenetic information. It is defined by the histone molecules that constitute the nucleosome, the positioning of the nucleosomes along the DNA and the non-histone prote...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2016-01-27 | PXD002537 | Pride
Acetylation  affinity proteomics  chromatin function or biology  label-free quantification   macromolecular assemblages 
ProteomicsThe kinase NEK6 positively regulates LSD1 activity and accumulation in local chromatin sub-compartments (CSCs)
LSD1 is involved in multiple essential roles in mammalian biology and various modes of LSD1 regulation are described ranging from interaction with specific coregulators to distinct post translational modifications. Here we show that NEK6 positively influences LSD1 activity and we observe a strong c...
ORGANISM(S): Escherichia Coli 
2024-10-27 | PXD049227 | JPOST Repository
TranscriptomicsOpen chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function [Agilent expression]
The epithelium lining the epididymis in the male reproductive tract maintains a luminal environment that promotes sperm cell maturation. This process is dependent on the coordinated expression of many genes that encode proteins with a role in epithelial transport. We previously generated genome-wide...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-60381 | biostudies-arrayexpress
GenomicsCombinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells
Hundreds of Chromatin Regulators (CRs) control chromatin structure and function by catalyzing and binding histone modifications, yet the rules governing these key processes remain obscure. Here, we present a systematic approach to infer CR function. We developed ChIP-string, a meso-scale assay that ...
ORGANISM(S): Homo sapiens 
2011-12-23 | E-GEOD-32509 | biostudies-arrayexpress
ProteomicsProteomics dataset for interphase chromatin probabilities
Chromatin proteins mediate replication, regulate expression and ensure integrity of the genome. So far, a comprehensive inventory of interphase chromatin has not been determined. This is largely due to its heterogeneous and dynamic composition, which makes conclusive biochemical purification difficu...
ORGANISM(S): Homo sapiens (Human) 
2014-02-18 | PXD000493 | Pride
Human Interphase Icps Chromatin 
TranscriptomicsOpen chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function [Rnase-Seq]
The epithelium lining the epididymis in the male reproductive tract maintains a luminal environment that promotes sperm cell maturation. This process is dependent on the coordinated expression of many genes that encode proteins with a role in epithelial transport. We previously generated genome-wide...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-59781 | biostudies-arrayexpress
TranscriptomicsRSC and ISW1 Chromatin Remodelers Display Functional and Chromatin-based Promoter Antagonism [ChIP-chip]
ISWI-family chromatin remodelers organize nucleosome arrays, while SWI/SNF-family remodelers (RSC) disorganize and eject nucleosomes, implying an antagonism that is largely unexplored in vivo. Here, we describe two independent genetic screens for rsc suppressors that yielded mutations in the promote...
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-01 | E-GEOD-65589 | biostudies-arrayexpress
GenomicsAn Estrogen Receptor α-bound Human Chromatin Interactome
We developed Chromatin Interaction Analysis by Paired-End Tag sequencing (ChIA-PET) for de novo detection of global chromatin interactions, and comprehensively mapped the chromatin interaction network bound by estrogen receptor α (ERα) in the human genome. We performed 454 and Illumina sequencing an...
ORGANISM(S): Homo sapiens 
2009-09-11 | E-GEOD-18046 | biostudies-arrayexpress
ProteomicsChromatin transaction map during vertebrate mitotic entry
We have used a combination of chemical genetics, chromatin proteomics and imaging to map the earliest chromatin transactions during vertebrate cell entry into mitosis. Chicken DT40 Cdk1as cells undergo synchronous mitotic entry within 15 minutes following release from a 1NM-PP1-induced arrest in lat...
ORGANISM(S): Gallus gallus (Chicken) 
2022-01-31 | PXD026385 | Pride
Silac Chicken Chromatin Mitosis 
Sort   by:  
 Page size