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TranscriptomicsTranscription profiling of S. cerevisiae (budding yeast) mutants reveals Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and programmed cell death
Changes in the transcriptome of Isc1p deficient mutants. The inositolphosphosphingolipid phospholipase C (Isc1p) of Saccharomyces cerevisiae belongs to the family of neutral sphingomyelinases that generates the bioactive sphingolipid ceramide. In this work the role of Isc1p in oxidative stress resis...
ORGANISM(S): Saccharomyces cerevisiae 
2008-02-05 | E-MEXP-1136 | biostudies-arrayexpress
GenomicsStructural clusters of histone H3 and H4 residues regulate chronological lifespan in Saccharomyces cerevisiae [Other]
Structural clusters of histone H3 and H4 residues regulate chronological lifespan in Saccharomyces cerevisiae [Other]
PRJNA588445 | ENA
ProteomicsMethionine restriction extends yeast lifespan by activating non-nitrogen-starvation-induced autophagy through limiting methylation of protein phosphatase 2A
Methionine restriction (MR) extends the lifespan and healthspan of numerous eukaryotic organisms, but the molecular mechanisms at play are unclear. Here we find that the ability of MR to extend the budding yeast chronological and replicative lifespans is the consequence of reduced methionine convers...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-06-15 | PXD069602 | Pride
Autophagy Methylation Longevity Lifespan Phosphorylation Methionine restriction 
GenomicsStructural clusters of histone H3 and H4 residues regulate chronological lifespan in Saccharomyces cerevisiae [ChIP-seq]
Structural clusters of histone H3 and H4 residues regulate chronological lifespan in Saccharomyces cerevisiae [ChIP-seq]
PRJNA593029 | ENA
GenomicsStructural clusters of histone H3 and H4 residues regulate chronological lifespan in Saccharomyces cerevisiae [RNA-seq]
Structural clusters of histone H3 and H4 residues regulate chronological lifespan in Saccharomyces cerevisiae [RNA-seq]
PRJNA595485 | ENA
GenomicsStructural clusters of histone H3 and H4 residues regulate chronological lifespan in Saccharomyces cerevisiae [Sir3 ChIP-seq]
Structural clusters of histone H3 and H4 residues regulate chronological lifespan in Saccharomyces cerevisiae [Sir3 ChIP-seq]
PRJNA593048 | ENA
ProteomicsSit4 genetically interacts with Vps27 to regulate mitochondrial function and lifespan in Saccharomyces cerevisiae
Sit4 is a PP2A-like Ser/Thr protein phosphatase implicated in the regulation of cellular processes important for cell survival during aging. We have previously shown that SIT4 deletion promotes vacuolar acidification, mitochondrial derepression and oxidative stress resistance, increasing yeast chron...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-05-24 | PXD048450 | Pride
Sit4  vps27  vacuolar trafficking  mitochondria  iron  chronological aging 
ProteomicsIdentification of aal1 long non-coding RNA physically interacting proteins
Genomes pervasively produce long non-coding RNAs (lncRNAs) of largely unknown functions. Some of these lncRNAs have been implicated in roles related to ageing and associated diseases. Here we characterize aal1 (ageing-associated lncRNA 1) which is induced in non-dividing, ageing cells of fission yea...
ORGANISM(S): Saccharomyces cerevisiae/Schizosaccharomyces pombe fusant 
2024-09-05 | PXD045625 | Pride
Ribosomes Fission yeast Chronological lifespan 
GenomicsHydrogen sulfide treatment at the late growth stage of Saccharomyces cerevisiae extends chronological lifespan
Hydrogen sulfide treatment at the late growth stage of Saccharomyces cerevisiae extends chronological lifespan
PRJNA672161 | ENA
UnknownUncoupling reproduction from metabolism extends chronological lifespan in yeast.
Not available
S-EPMC3992631 | biostudies-literature
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