Sort   by:  
 Page size 
MetabolomicsSingle-cell metabolic fingerprints discover a cluster of circulating tumor cells with distinct metastatic potential

Circulating tumor cells (CTCs) are recognized as direct seeds of metastasis. However, CTC count may not be the 'best' indicator of metastatic risk because their heterogeneity is generally neglected. In this study, we develop a molecular typing system to predict colorectal cancer metastasis potent...

2023-08-21 | MTBLS5028 | MetaboLights
ProteomicsColorectal cancer Circulating tumor cells released Extracelluar Vesicles proteome cargo analysis
Background: Circulating tumor cells (CTCs) play a key role in cancer progression, and in vitro CTC models are essential for studying their biology. This study examined extracellular vesicles (EVs) from CTC lines of a metastatic colorectal cancer (mCRC) patient who progressed despite therapy. Methods...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055639 | Pride
Extracellular vesicles Colorectal cancer Circulating tumor cells 
MetabolomicsCirculating cell populations as response predictors and targets to improve immunotherapy in metastatic lung cancer

The effectiveness of immunotherapy varies among patients with advanced non-small cell lung cancer (NSCLC). Here we investigated the baseline immune status in stage IV NSCLC patients treated with anti-PD-1 plus chemotherapy to understand the immune mechanisms and unveil systemic markers associated...

2025-10-16 | MTBLS13150 | MetaboLights
TranscriptomicsMolecular profiling of single circulating tumor cells with diagnostic intention
About 230 clinical trials currently explore the role of circulating tumor cell (CTC) analysis for therapy decisions, but no assays enable comprehensive molecular characterization of CTCs with diagnostic precision. We therefore combined a workflow for CTC enrichment and isolation with 100% purity wit...
ORGANISM(S): Homo sapiens 
2014-11-05 | E-GEOD-58192 | biostudies-arrayexpress
TranscriptomicsSingle Cell RNA-sequencing of Pancreatic Circulating Tumor Cells
Circulating Tumor Cells (CTCs) are shed from primary tumors into the bloodstream, mediating the hematogenous spread of cancer to distant organs. Using a pancreatic cancer mouse model, we applied a microfluidic device to isolate CTCs independently of tumor epitopes, subjecting these to single cell RN...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-51372 | biostudies-arrayexpress
UnknownDo circulating tumor cells, exosomes, and circulating tumor nucleic acids have clinical utility? A report of the association for molecular pathology.
Not available
S-EPMC4411248 | biostudies-literature
TranscriptomicsTumor circulating DNA profiling in xenografted mice exposed to intermittent hypoxia
Intermittent hypoxia (IH) is a hallmark of obstructive sleep apnea (OSA), which has been proposed as the major determinant of processes involving tumor invasion and metastasis. To study whether circulating DNA (cirDNA) in blood plasma reflects the changes that the tumor cells undergo under IH condit...
ORGANISM(S): Mus musculus 
2015-02-24 | E-GEOD-61070 | biostudies-arrayexpress
TranscriptomicsIsolation and expression profiling of circulating tumor cells in breast cancer patients part 1
We developed a method to isolate pure circulating tumor cells (CTC). RNA from such CTCs isolated from the peripheral blood of metastatic breast cancer patients and gene expression was performed using cDNAmicroarray. we used cDNA array to compare gene expression of CTCs with normal epithelial and b...
ORGANISM(S): Homo sapiens 
2014-12-18 | E-GEOD-45962 | biostudies-arrayexpress
TranscriptomicsIsolation and expression profiling of circulating tumor cells in breast cancer patients part 3
We developed a method to isolate pure circulating tumor cells (CTC). RNA from such CTCs isolated from the peripheral blood of metastatic breats cnacer patients and gene expression was performed using cDNAmicroarray. we used cDNA array to compare gene expression of CTCs with normal epithelial and b...
ORGANISM(S): Homo sapiens 
2014-12-18 | E-GEOD-45964 | biostudies-arrayexpress
TranscriptomicsIsolation and expression profiling of circulating tumor cells in breast cancer patients part 2
We developed a method to isolate pure circulating tumor cells (CTC). RNA from such CTCs isolated from the peripheral blood of metastatic breats cnacer patients and gene expression was performed using cDNAmicroarray. we used cDNA array to compare gene expression of CTCs with normal epithelial and b...
ORGANISM(S): Homo sapiens 
2014-12-18 | E-GEOD-45963 | biostudies-arrayexpress
Sort   by:  
 Page size