Sort   by:  
 Page size 
TranscriptomicsExpression data identifying hypermethylated genes associated with acquired cisplatin resistance
Treatment-related DNA hypermethylation may play a role in creating drug resistant phenotypes by inactivating genes that are required for cytotoxicity, but there have been no genome-wide studies to systematically investigate methylation of individual genes following exposure to chemotherapy. We used ...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-19397 | biostudies-arrayexpress
TranscriptomicsMEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma (SCC)
Genomic analyses of SCC have yet to yield significant strategies against pathway activation to improve treatment. Platinum-based chemotherapy remains the mainstay of treatment for SCC of different histotypes either as a single agent or alongside other chemotherapeutic drugs or radiotherapy; however,...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-66549 | biostudies-arrayexpress
TranscriptomicsComparison of H460 derived CSCs and cisplatin-resistant cells
Transcription profile of cancer stem cells isolated from human non-small cells lung cancer (NSCLC) H460 cells. The profile of H460 cells that were made resistant to cisplatin after a single treatment with the drug was also determined. Both profiles were finally compared. Each microarray contained on...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-54981 | biostudies-arrayexpress
TranscriptomicsTranscript analyses of cisplatin and Sky1 effects in Saccharomyces cerevisiae
Sky1 is a Saccharomyces cerevisiae rich serine-arginine (SR) protein-specific kinase and its enzymatic activity is essential in the cytotoxicity caused by cisplatin, although the molecular mechanisms supporting this function are not understood. We present a transcriptome analysis discriminating betw...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-01 | E-GEOD-41094 | biostudies-arrayexpress
TranscriptomicsReal-time Monitoring of Cisplatin Toxicity on Cancer Cells
Treatment of MCF7 breast cancer cells by cisplatin leads to a very specific metabolic response and an onset of cell death about 10-11 h after beginning of treatment. For more detailed understanding of the molecular processes underlying the specific metabolic response, mRNA was isolated from MCF7 cel...
ORGANISM(S): Homo sapiens 
2011-04-04 | E-GEOD-28274 | biostudies-arrayexpress
ProteomicsDown-regulation of Rab 5C-dependent Endocytosis and Glycolysis in Cisplatin-resistant Ovarian Cancer Cell Lines
Drug resistance poses a major challenge to ovarian cancer treatment. Understanding mechanisms of drug resistance is important for finding new therapeutic targets. In the present work, a cisplatin-resistant ovarian cancer cell line A2780-DR was established with a resistance index of 6.64. The cellula...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080724 | MassIVE
TranscriptomicsDichloroacetate (DCA) prevents cisplatin-induced nephrotoxicity without compromising its anti-cancer properties.
The aim of this study was to compare the transcriptional changes that occur in the kidneys of mice administered cisplatin or DCA, or both, by RNA-seq. generation of RNA-seq datasets from mice subjected to 4 different treatments. 3 biological replicates per treatment. Saline treatment is control.
ORGANISM(S): Mus musculus 
2016-03-09 | E-GEOD-69652 | biostudies-arrayexpress
GenomicsGenome-wide maps of methylation state in cisplatin sensitive and resistant ovarian cancer cell line
We report the application of methyl-binding protein sequencing (MBD-seq) to global identify aberrant methylation between cisplatin sensitive and resistant ovarian cancer cell lines Detection of aberrant methylation states between cisplatin sensitive and resistant cell lines
ORGANISM(S): Homo sapiens 
2012-04-10 | E-GEOD-31418 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A549 NSCLC cells cisplatin induced changes
Affymetrix high-density oligonucleotide microarray analysis was performed to analyse cisplatin-induced gene expression changes in A549 NSCLC cells. Cells were treated with 50 µM of cisplatin for 1 hour and incubated for a further 10 hours in drug-free media before the gene expression changes were i...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6410 | biostudies-arrayexpress
ProteomicsProteome Analysis of Non-Small Cell Lung Cancer Cell Line Secretomes and Patient Sputum Reveals Biofluid Biomarker Candidates for Cisplatin Response Prediction
We profiled the secretomes of 6 NSCLC cell lines with varying IC50-values for cisplatin, using label-free GeLC-MS/MS-based proteomics. Out of a total dataset of 2618 proteins, 304 proteins showed significant differences in expression levels between cisplatin sensitive and insensitive cell lines. Fun...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD011315 | Pride
Label-free gelc-ms/ms  non-small cell lung cancer (nsclc)  secretome  sputum  cisplatin sensitivity  biomarkers 
Sort   by:  
 Page size