colonic epithelial cells

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Unknown (1496)
Transcriptomics (542)
Genomics (474)
Proteomics (69)
Metabolomics (13)
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Methylation profiling (5)
Clinical (4)
Models (2)

Organisms

Mus musculus (322)
Homo sapiens (293)
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Entamoeba histolytica (3)
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Salmonella enterica subsp. enterica serovar Typhimurium (2)
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mouse gut metagenome (1)
synthetic construct (1)
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Organisms

Mus musculus (222)
Homo sapiens (106)
mouse gut metagenome (5)
Escherichia coli (4)
Rattus norvegicus (4)
Macaca mulatta (3)
Salmonella enterica subsp. enterica serovar Typhimurium (2)
Bos taurus (2)
Citrobacter rodentium (1)
Entamoeba histolytica (1)
unidentified (1)
Oryctolagus cuniculus (1)
Mus (1)
Bacteria (1)
human gut metagenome (1)
Sus scrofa (1)

Repository

ENA (437)
biostudies-arrayexpress (302)
geo (279)
pride (45)
MetaboLights (13)
MassIVE (12)
EGA (7)
iProX (6)
jPOST (6)
ExpressionAtlas (3)
BioModels (1)
Cell Collective (1)

Tissue

Colon (20)
Epithelial cell (20)
Cell culture (6)
Colon epithelial cell (6)
Colonic cancer cell line (3)
Ileum (2)
Intestinal epithelial cell (2)
Intestine (2)
Colonic epithelial cell (1)
Colonic mucosa (1)
Goblet cell (1)
HCT-116 cell (1)
Intestinal epithelium (1)
Lung (1)
Macrophage (1)
SW-480 cell (1)
Spleen (1)
T cell (1)

Disease

Colon cancer (7)
Inflammatory bowel disease (4)
Crohn's disease (3)
Adenoma (2)
Colon carcinoma (2)
Colorectal adenocarcinoma (2)
Carcinoma (2)
Colitis (2)
Colon adenocarcinoma (2)
Clostridium difficile colitis (1)
Colon Cancer (1)
Unaffected (1)
Acute promyelocytic leukemia (1)
Colorectal Cancer (1)
Carcinoma, Ovarian Epithelial (1)
Neoplasms (1)
Allergic asthma (1)
Bacterial infectious disease (1)
Chronic inflammation (1)
Chronic kidney disease (1)
Chronic obstructive pulmonary disease (1)
Disease free (1)
Inflammatory bowel disease 1 (1)
Obesity (1)
Ulcerative colitis (1)

Technology Type

Mass Spectrometry (45)
Shotgun proteomics (29)
Bottom-up proteomics (10)
Mass spectrometry (6)
Mass spectrometry assay (6)
Data-dependent acquisition (3)
Data-independent acquisition (2)
Gel-based experiment (2)
Top-down proteomics (2)
NMR spectroscopy (1)
Affinity purification coupled with mass spectrometry proteomics (1)
DiaPASEF (1)
HDMSE (1)

Instrument Platform

Illumina HiSeq 2500 (12)
Illumina NovaSeq 6000 (9)
Q Exactive (6)
Liquid Chromatography MS - negative - reverse phase (5)
Illumina HiSeq 2000 (4)
Illumina HiSeq 4000 (4)
Liquid Chromatography MS - positive - reverse phase (4)
10x Genomics Chromium Controller (3)
NextSeq 500 (3)
Affymetrix GeneChip Scanner 3000 7G (2)
Q Exactive HF (2)
Liquid Chromatography MS - alternating - reverse-phase (2)
Liquid Chromatography MS - negative - reverse-phase (2)
Liquid Chromatography MS - positive - reverse-phase (2)
Next GEM Single Cell 3' Gel Bead kit v3.1 (1)
Chromium Nuclei Isolation kit (10x Genomics 1000493) (1)
Agilent (1)
Fluidigm C1 (1)
Illumina Genome Analyzer IIx (1)
ScanArray Express HT [PerkinElmer] (1)
N/A (1)
NextSeq 2000 (1)
BGISEQ-500 (1)
Illumina MiSeq (1)
NextSeq 550 (1)
Agilent 6530 QTOF (1)
LTQ Orbitrap (1)
LTQ Orbitrap Velos (1)
TripleTOF 5600 (1)
Gas Chromatography MS - positive - high-polarity (1)

Publication Date

2025 (60)
2014 (52)
2015 (52)
2026 (49)
2024 (40)
2023 (38)
2013 (37)
2022 (35)
2011 (34)
2016 (32)
2021 (29)
2020 (29)
2012 (29)
2019 (27)
2010 (27)
2018 (21)
2008 (19)
2017 (17)
2009 (16)
2007 (9)
2005 (7)
2004 (3)
2006 (2)

CHEBI ID

CHEBI:30768 (3)
CHEBI:15366 (2)
CHEBI:15741 (2)
CHEBI:15956 (2)
CHEBI:17596 (2)
CHEBI:30772 (2)
CHEBI:119915 (1)
CHEBI:123115 (1)
CHEBI:132302 (1)
CHEBI:137124 (1)
CHEBI:137296 (1)
CHEBI:138770 (1)
CHEBI:138785 (1)
CHEBI:144354 (1)
CHEBI:145255 (1)
CHEBI:149468 (1)
CHEBI:15354 (1)
CHEBI:15355 (1)
CHEBI:15428 (1)
CHEBI:15493 (1)
CHEBI:15611 (1)
CHEBI:156126 (1)
CHEBI:156168 (1)
CHEBI:15688 (1)
CHEBI:15760 (1)
CHEBI:157665 (1)
CHEBI:15784 (1)
CHEBI:15891 (1)
CHEBI:15940 (1)
CHEBI:15971 (1)

Metabolite Name

Creatine (6)
Guanosine (6)
Hypoxanthine (6)
Asparagine (5)
Cholic acid (5)
Citrulline (5)
Deoxyguanosine (5)
Inosine (5)
Oleamide (5)
Riboflavin (5)
Sarcosine (5)
Taurine (5)
Taurocholic acid (5)
Thymine (5)
Uridine (5)
1-Methylxanthine (4)
20-Hydroxyeicosatetraenoic acid (4)
23-Nordeoxycholic acid (4)
3-FORMYLINDOLE (4)
3-Hydroxyanthranilic acid (4)
3-phosphoglycerate (4)
5'-Deoxyadenosine (4)
5-Hydroxy-L-tryptophan (4)
Adenosine (4)
Agmatine (4)
Alanine (4)
Alanylphenylalanine (4)
Allocholic acid (4)
Arginine (4)
Aspartate (4)

First Public Date

2025 (66)
2023 (54)
2026 (52)
2014 (45)
2024 (44)
2022 (41)
2021 (37)
2019 (27)
2020 (26)
2018 (18)
2015 (9)
2017 (7)
2016 (6)
2013 (5)

Modelling Approach

Ordinary differential equation model (1)

Study status

Completed (2)
Active, not recruiting (1)
Terminated (1)

Lab affiliation

ICR, Functional Proteomics (2)
The Institute of Cancer Research (2)
Vanderbilt University Proteomics Core (2)
Xi'an Jiaotong University (2)
Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Canada (1)
CRUK Beatson Institute (1)
Conway Institute of Biomolecular and Biomedical Research,School of Medicine, University College Dublin (1)
Department of Applied Biological Science, College of Bioresource Sciences, Nihon University (1)
Department of Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada; Department of Physiology and Pharmacology, University of Calgary, Alberta, Canada; The Hotchkiss Brain Institute, University of Calgary, Alberta, Canada; McCaig Institute for Bone and Joint Health, University of Calgary, Alberta, Canada (1)
Department of Biomedicine, Aarhus University (1)
Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China (1)
Department of Immunology and Regenerative Biology, The Weizmann Institute of Science (1)
Department of Life Science, National Taiwan University, Taipei, Taiwan. (1)
Department of Medical Biochemistry and Cell biology, University of Gothenburg, Sweden (1)
Department of Medical Biochemistry, University of Gothenburg (1)
Department of Pharmacology School of Medicine University of Texas Medical Branch at Galveston (1)
Dept. of Physiology, University of Toronto, Toronto, ON, Canada Dept. of Medicine, University of Toronto, Toronto, ON, Canada (1)
Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada (1)
Functional Proteomics, ICR (1)
Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, 60596 Frankfurt/Main, Germany Frankfurt Cancer Institute, Goethe University Frankfurt, 60596 Frankfurt/Main, Germany German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany (1)
Institute of Cancer Research (1)
Institute of Cancer Research, London (1)
Laboratoire de Spectrometrie de Masse Proteomique Institut Curie PSL Research University (1)
Laboratory of Foodomics, Institute of Food Science Research (CIAL, CSIC), Calle Nicolás Cabrera 9, 28049, Madrid, Spain (1)
Laboratory of Foodomics, Institute of Food Science Research (CIAL, CSIC), Calle Nicolás Cabrera 9, 28049, Madrid, Spain. (1)
Laboratory of Immunoinflammation, Department of Genetics and Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Brazil (1)
Laboratory of Translational Gastroenterology and Hepato-Gastroenterology and Digestive Oncology University of Liège,University Hospital CHU of Liège, Liège, Belgium (1)
Mucin Biology Group Proteomics Laboratory Department of Medical Biochemistry and Cell Biology University of Gothenburg (1)
Mucin Biology Group, Proteomics Laboratory, Department of Medical Biochemistry and Cell Biology, University of Gothenburg (1)
North Carolina State University (1)

Keyword

Trastuzumab (2)
7-hydroxystaurosporine (1)
Adavosertib (1)
Ado-Trastuzumab Emtansine (1)
Afatinib (1)
Albumin-Bound Paclitaxel (1)
Antibodies (1)
Antibodies, Monoclonal (1)
Carboplatin (1)
Crizotinib (1)
Dabrafenib (1)
Dasatinib (1)
GSK2636771 (1)
Immunoconjugates (1)
Immunoglobulin G (1)
Immunoglobulins (1)
Interleukin-12 (1)
Ipatasertib (1)
Irinotecan (1)
Maytansine (1)
Motexafin lutetium (1)
Nivolumab (1)
Osimertinib (1)
Palbociclib (1)
Pertuzumab (1)
Relatlimab (1)
Sunitinib (1)
Trametinib (1)
Trastuzumab biosimilar HLX02 (1)
Tyrosine Protein Kinase Inhibitors (1)

IsPrivate

False (1)

Classification

bacteria (7)
protozoa (1)

Study type

Transcription profiling by array (205)
RNA-seq of coding RNA (37)
Methylation profiling by array (10)
Comparative genomic hybridization by array (9)
ChIP-seq (6)
RNA-seq of coding RNA from single cells (6)
Unknown experiment type (4)
Methylation profiling by high throughput sequencing (4)
Interventional (4)
Other (3)
ChIP-chip by tiling array (2)
Genotyping by array (2)
Transcription profiling by SAGE (1)
RNA-seq of non coding RNA from single cells (1)
Human - High-throughput sequencing (1)
High-throughput sequencing (1)
Animal - High-throughput sequencing (1)
Cell line - High-throughput sequencing (1)
RNAi profiling by array (1)
ChIP-chip by array (1)
ATAC-seq (1)
Hi-C (1)
Single nucleus RNA sequencing (1)
MicroRNA profiling by array (1)
RNA-seq of total RNA (1)

Release Date

2022 (166)
2023 (146)
2025 (134)
2021 (132)
2024 (117)
2015 (115)
2019 (106)
2020 (104)
2014 (100)
2016 (92)
2018 (89)
2017 (80)
2013 (78)
2012 (68)
2011 (63)
2010 (51)
2009 (45)
2008 (38)
2026 (18)
2007 (17)
2005 (12)
2006 (9)
2003 (6)
2004 (4)
2002 (2)
1999 (2)
1998 (2)
2001 (1)
2000 (1)

Location

United States (4)
Guam (1)
Puerto Rico (1)

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Transcription profiling by array of colonic epithelial cells from mice starved, subsequently refed with or without antibiotics metronidazol and vancomycin

Oral food intake maintains gastrointestinal cell turnover and impacts the morphology and function of intestinal epithelial cells. However, the underlying mechanism is not fully elucidated, especially in the large intestine. Therefore, we analyzed the colonic epithelial cell turnover in starved and r...

ORGANISM(S): Mus musculus

2014-08-11 | E-GEOD-40370 | biostudies-arrayexpress

ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights

Immunoregulatory actions of epithelial cell PPAR g at the colonic mucosa

BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation. The objective of this study was to use a systems approach for investigating the mechanism by which the deletion o...

ORGANISM(S): Mus musculus

2010-07-08 | E-GEOD-20621 | biostudies-arrayexpress

Transcription profiling of mouse colonic epithelial cells treated with sodium butyrate to investigate how sodium butyrate induces arrest of cell cycle and differentiation

We performed global scale microarray analysis to identify detailed mechanisms by which sodium butyrate (SB) induce cell growth arrest and differentiation of colonic epithelial cells by using an Affymetrix GeneChip system. Colonic epithelial MCE301 cells used in this study were derived from transgeni...

ORGANISM(S): Mus musculus

2007-12-07 | E-GEOD-4410 | biostudies-arrayexpress

Gene expression of the colonic epithelial cells in CRB mice fed with HFD and LFD

To elucidate the mechamisms of colonic Treg cell induction by microbial metabolite(s), chroloform-resistant bacteria (CRB)-associated mice was developed and given low-fiber diet (LFD) and high-fiber diet (HFD). The colonic epithelial cells were isolated and gene expression profiles were analyzed by ...

ORGANISM(S): Mus musculus

2014-08-11 | E-GEOD-41104 | biostudies-arrayexpress

Dietary hispidulin ameliorated chemically-Induced colitis by inhibiting epithelial cell ferroptosis via the ACAT2-GPX4 axis and remodeling the gut microbiota

Hispidulin, a dietary flavonoid occurring naturally in brown algae, has attracted considerable interest owing to its functions in modulating inflammatory responses and neutralizing reactive oxygen species. This study examined the consequences of hispidulin in a model of chemically induced acute c...

2025-08-05 | MTBLS12818 | MetaboLights

Differential expression of microRNA in Muc2-/- mouse colonic epithelial cells

Intestinal epithelia are protected by a layer of mucin secreted by goblet cells against mechanical and chemical injuries, potent causes of inflammation, and the most abundant secreted intestinal mucin is encoded by the Muc2 gene. Genetic deletion of Muc2 causes intestinal inflammation in early stage...

ORGANISM(S): Mus musculus

2014-05-31 | E-GEOD-56577 | biostudies-arrayexpress

Microbial-Derived Metabolites Regulate the Colonic Crypt Niche

In the mammalian intestine, crypts of LeiberkÃ¼hn house intestinal epithelial stem /progenitor cells at their base. We found that the presence of this structure was supported by the physiologic role of a prominent bacterial metabolite, butyrate. This bacterially-produced short chain fatty acid inhib...

ORGANISM(S): Mus musculus

2016-06-27 | E-GEOD-74601 | biostudies-arrayexpress

Isolation and in vitro expansion of human colonic stem cells [Expression profile]

Using the surface marker EPHB2, we have FACS-purified and profiled stem cell-enriched cell fractions from normal human mucosa, crypt proliferative progenitors and late transient amplifying cells to define a gene expression program specific for normal human colon epithelial stem cells We FACS purifie...

ORGANISM(S): Homo sapiens

2011-11-22 | E-GEOD-31255 | biostudies-arrayexpress

Transcriptomic analysis of colonic epithelial cells in adult rats born with intra-uterine growth retardation.

The impact of intra-uterine growth retardation (IUGR) was analyzed on gene expression of the colonic epithelial cells from adults rats fed a standard or a high-fat diet. The hypothesis tested in this study was that IUGR induces sustainable effects on colonocyte transcriptome that may alter further n...

ORGANISM(S): Rattus norvegicus

2015-11-01 | E-GEOD-65051 | biostudies-arrayexpress

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