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MetabolomicsElectroacupuncture at Ll11 and SP10 is associated with alleviation of acute urticaria-like reactions in passive cutaneous anaphylaxis: an exploratory analysis of complement-related proteins and multiscale omics

Background: The lifetime prevalence of acute urticaria is approximately 20%. Although electroacupuncture (EA) has been investigated as an adjunctive treatment for urticaria, the molecular mechanisms underlying these effects remain elusive. Passive cutaneous anaphylaxis (PCA) serves as an experime...

2026-06-03 | MTBLS14327 | MetaboLights
TranscriptomicsRegulation of neuronal gene and miRNA expression by the complement protein C1q associated with neuroprotection
Identification of transcriptional profiles stimulated by the complement protein C1q in rat immature neurons associated with the C1q-dependent neuroprotection observed in vitro. Use of the unbiased whole genome microarray approach to identify genes regulated by C1q. Immature neurons grown in vitro fo...
ORGANISM(S): Rattus norvegicus 
2011-03-07 | E-GEOD-18860 | biostudies-arrayexpress
TranscriptomicsRepeated systemic challenge with lipopolysaccharides induces dopaminergic neurodegeneration in the brain by activation of the complement-phagosome pathway
Systemic inflammatory reactions mediated by chronic infections activate microglia in the central nervous system (CNS) and have been postulated to exacerbate neurodegenerative diseases. We now demonstrate in vivo that repeated systemic challenge of mice with bacterial lipopolysaccharides (LPS) mainta...
ORGANISM(S): Mus musculus 
2014-07-11 | E-MTAB-1770 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of endogenous genes and luciferase reporters in human HeLa cells to examine the effect of seed complement frequency on off-target signatures
siRNAs were designed against both endogenous genes and luciferase reporters to examine the effect of seed complement frequency on off-target signatures as measured by Agilent Human 1A gene expression analysis.
ORGANISM(S): Homo sapiens 
2008-03-15 | E-MEXP-1402 | biostudies-arrayexpress
TranscriptomicsLocal regulation and clinical impact of complement gene expression in deceased and living donor kidney allografts
The biopsy samples obtained at implantation segregated in 2 distinct groups according to donor origin, with a cluster of 319 unique identified genes higher expressed in DD compared to LD kidneys, and 329 genes lower expressed (false discovery rate <5%). Using pathway analysis software a significant ...
ORGANISM(S): Homo sapiens 
2008-04-16 | E-GEOD-11166 | biostudies-arrayexpress
ProteomicsProfiling antibody function on antigen arrays
Humoral immune responses are traditionally characterized by determining the presence and quality of antibodies specific for certain antigens. Arraying of large numbers of antigens allows the parallel measurement of antibodies, generating patterns called antibody profiles. Functional characterization...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-12943 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of dendritic cells from three different human donors to characterize the impact of differential HIV opsonization on dendritic cell modulation
The aim of this study was to characterize the impact of differential HIV opsonization on DC modulation. DCs are the most potent antigen-presenting cells and among the first cells HIV is attaching to. HIV spontaneously activates the complement system even in the absence of specific antibodies and is ...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-MEXP-3706 | biostudies-arrayexpress
TranscriptomicsDeciphering the genetic basis of Moraxella catarrhalis complement resistance: Gene expression analysis of Moraxella catarrhalis BBH18 upon exposure to normal human serum.
The complement system is an important part of the innate defense against invading pathogens. The ability to resist complement-mediated killing is considered to be an important virulence trait for the human-restricted respiratory tract pathogen M. catarrhalis, as most disease-associated M. catarrhali...
ORGANISM(S): Moraxella catarrhalis BBH18 
2014-06-23 | E-GEOD-52552 | biostudies-arrayexpress
GenomicsGene-expression profiles of HepG2.2.15 cells induced by overexpression of Complement 2
Gene-expression profiles of HepG2.2.15 cells induced by overexpression of Complement 2
PRJNA601970 | ENA
ProteomicsComplement profiling on sural nerves of patients with chronic inflammatory demyelinating polyneuropathy
Overall, 55 sural nerve biopsies from patients with CIDP (n=36) and CIDP-variants (n=18) were included into the study. Immunohistochemical analysis of the sural nerve specimens showed an aberrant deposition of terminal complement complex C5b-9 on endoneural capillaries in 52 (94%) of patients in add...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD056286 | Pride
Proteomics Gene expression Chronic inflammatory demyelinating polyneuropathy  complement profiles  sural nerve 
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