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MetabolomicsMetabolomics highlights reduced glutamate and acetylcarnitine in the amniotic fluid of cytomegalovirus-infected pregnant women

Cytomegalovirus (CMV) is a ubiquitous infectious agent that causes significant morbidity in immunosuppressed hosts and is the most common cause of neonatal congenital deafness.An infection acquired during pregnancy can be vertically transmitted to the fetus and cause permanent sequelae in the new...

2025-09-12 | MTBLS12415 | MetaboLights
ProteomicsIdentification of new amniotic fluid prognostic biomarkers of congenital cytomegalovirus infection severity
Background: Congenital cytomegalovirus (cCMV) is a common intrauterine infection, leading to neurodevelopmental disabilities. Early prognostic assessment of the severity of cCMV has remained an ongoing challenge. We aimed to identify amniotic fluid biomarkers of the severity of cCMV-related fetal br...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus sp. 
2022-05-25 | PXD029105 | Pride
Cytomegalovirus  congenital cytomegalovirus infection  amniotic fluid biomarkers 
TranscriptomicsFunctional exhaustion of fetal Th1 lymphocytes following congenital CMV infection - Huygens A. Marchant A.
Comparison of the transcriptome of naive (CD45RA+ CD27+) and differentiated (CD27-CD28-) CD4+ lymphocytes from newborns with congenital human cytomegalovirus infection (cord blood samples) and pregnant women diagnosed with primary CMV infection. Naive cells from HCMV uninfected newborns were used as...
ORGANISM(S): Homo sapiens 
2015-01-18 | E-MEXP-3473 | biostudies-arrayexpress
TranscriptomicsHuman induced pluripotent stem cell-technology to study the effects of human cytomegalovirus infection on neural differentiation
Congenital human cytomegalovirus (HCMV) infection is one of the leading prenatal causes of mental retardation and congenital deformities world-wide. Access to cultured human neuronal lineages, necessary to understand the species specific pathogenic effects of HCMV has been limited by difficulties i...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-35295 | biostudies-arrayexpress
ProteomicsHuman Cytomegalovirus modifies placental small extracellular vesicle secretion and composition to enhance infection of fetal recipient cells
Human cytomegalovirus (hCMV) primo-infection, reinfection and/or reactivation is a major issue during pregnancy and affects 1% of live births in western countries, making hCMV the most frequently transmitted virus in utero. Despite the extensive research conducted so far, the pathophysiology of this...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Homo sapiens (Human) 
2022-10-13 | PXD029146 | Pride
Neural stem cells Hcmv Congenital infection Extracellular vesicles Placenta Cytotrophoblast 
UnknownParenting a child with congenital cytomegalovirus infection: a qualitative study.
Not available
S-EPMC7662527 | biostudies-literature
GenomicsHLA-E restricted cytomegalovirus UL40 peptide polymorphism may represent a risk factor following congenital infection
UL4015-23 peptide in congenital cytomegalovirus infection
PRJEB50267 | ENA
TranscriptomicsCystic leukoencephalopathy without megalencephaly
The cystic leukoencephalopathy without megalencephaly has been defined as distinct autosomal-recessive syndrome of quasi-static encephalopathy with normo- or microcephaly, impaired psychomotor development and characteristic pattern on brain MRI. We identified mutations in the gene encoding the RNASE...
ORGANISM(S): Homo sapiens 
2009-06-02 | E-GEOD-11964 | biostudies-arrayexpress
TranscriptomicsMicroRNA targetome analysis during HCMV infection
To elucidate miRNA-mediated temporal crosstalk during productive infection, we identified genome-wide miRNA target sites using Argonaute-crosslinking and immunoprecipitation followed by high-throughput sequencing (AGO-CLIPseq) in human cytomegalovirus (HCMV)-infected cells and evaluated the targetin...
ORGANISM(S): Homo sapiens 
2014-12-03 | E-GEOD-63797 | biostudies-arrayexpress
UnknownCongenital cytomegalovirus infection: Clinical presentation, epidemiology, diagnosis and prevention.
Not available
S-EPMC4934990 | biostudies-literature
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