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ProteomicsProteomic Profiling of Mammalian COPII Vesicles
By combining in vitro COPII vesicle reconstitutions and SILAC-based mass spectrometric analysis this study aims to identify the core proteome of mammalian COPII vesicles. Furthermore proteomes generated from vesicles with different Sec24 isoforms have been investigated with the same approach to iden...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD012128 | Pride
Silac Copii vesicels Proteomics 
ProteomicsThe Functions of the COPII Gene Paralogs SEC23A and SEC23B Are Interchangeable In Vivo
This dataset includes BioID for SEC23A and SEC23B. The paper describes the functional redundancy of these two gene paralogs in the context of human disease.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-09 | MSV000081703 | MassIVE
ProteomicsSEC23B-dependent COPII Vesicles Regulate T Cell Immunity
The coordinated release of proteins by T cells enables controlled biological responses. While the molecular mechanisms underlying T cell secretion are being increasingly understood, whether the critical ER-to-Golgi trafficking pathway regulates T cell immunity is not known. We utilized mice with a T...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015766 | Pride
Lc-msms Lymphocytes Mouse 
ProteomicsElucidation of the molecular changes underlying abnormal ER characteristic of osteosarcoma
Pediatric osteosarcomas are characterized by an unusually dilated endoplasmic reticulum (ER). Our analysis of RNA expression data from 108 patient tumor samples and patient-derived xenografts (PDXs) revealed the overwhelming majority of these tumor have reduced expression of four COPII vesicle comp...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031620 | Pride
Copii vesicle components Osteosarcoma Er homeostasis 
ProteomicsRHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling
The toll-like receptor 4 (TLR4) is a central regulator of innate immune signaling that primarily recognizes bacterial lipopolysaccharide (LPS) cell wall constituents to trigger cytokine secretion. We identify the intramembrane protease RHBDL4 as a negative regulator of TLR4 signaling. We show that R...
ORGANISM(S): Homo sapiens (Human) 
2024-01-09 | PXD045934 | Pride
Intramembrane proteolysis Protein homeostasis Rhomboid-family proteins Organelle proteomics Er-associated degradation Protein trafficking 
UnknownCOPII-Golgi protein interactions regulate COPII coat assembly and Golgi size.
Not available
S-EPMC2064162 | biostudies-literature
UnknownLysophospholipids Facilitate COPII Vesicle Formation.
Not available
S-EPMC6013297 | biostudies-literature
UnknownCOPII vesicles contribute to autophagosomal membranes.
Not available
S-EPMC6504894 | biostudies-literature
UnknownSec16 alternative splicing dynamically controls COPII transport efficiency.
Not available
S-EPMC4980449 | biostudies-literature
UnknownMultibudded tubules formed by COPII on artificial liposomes.
Not available
S-EPMC3216505 | biostudies-literature
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