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ProteomicsDistinct Extracellular Matrix Protein Signatures of Cortical and Cancellous Bone Allografts Following Processing for Clinical Use
Demineralized bone matrices (DBMs) are widely used in bone replacement therapy. Bone tissue of either cancellous or cortical origin is decellularized, demineralized, and sterilized during processing, while retaining portions of native organic extracellular matrix (ECM) proteins that regulate cell-ma...
ORGANISM(S): Homo sapiens (Human) 
2026-06-03 | PXD075611 | Pride
TranscriptomicsPeripheral blood mononuclear cell- and cortical bone-derived transcriptional profiles
Large-scale transcriptional profiling has enormous potential for discovery of osteoporosis susceptibility genes and for identification of the molecular mechanisms by which these genes and associated pathways regulate bone maintenance and turnover. A potential challenge in the use of this method for ...
ORGANISM(S): Papio hamadryas 
2013-10-22 | E-GEOD-51495 | biostudies-arrayexpress
MetabolomicsExamination of human osteoarchaeological remains as a feasible source of polar and apolar metabolites to study past conditions
Metabolomics is a modern tool that aids in our understanding of the molecular changes in organisms. Archaeological science is a branch of archaeology that explores different archaeological materials using modern analytical tools. Human osteoarchaeological material are a frequent finding in archaeolo...
2022-07-04 | MTBLS4437 | MetaboLights
ProteomicsBispecific antibody against sclerostin and DKK1 improves bone health and reduces bone marrow adipose accumulation in experimental chronic kidney disease
Chronic kidney disease (CKD) leads to bone loss and bone marrow adipose tissue (BMAT) accumulation. Sclerostin and dickkopf-1 (DKK1) are two inhibitors of Wnt signalling, which suppress bone formation, promote bone marrow adipogenesis, and are elevated in CKD. However, therapies targeting sclerostin...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD069117 | Pride
Bone Chronic kidney disease (ckd) 
ProteomicsPalaeoproteomic variation between cortical and trabecular bone
Here we provide proteomic datasets of pairs of cortical and trabecular bone from six Early Holocene Caprinae rib fragments from the site of La Draga, Spain, using shotgun proteomics. Our observations on proteome size and protein, peptide, and amino acid degradation have implications for the samplin...
ORGANISM(S): Caprinae 
2024-07-12 | PXD047126 | Pride
Shotgun proteomics Zooms Skeletal proteome variation Palaeoproteomics Proteome preservation 
ProteomicsBone proteomics methods optimisation for forensic investigations
The application of human bone in forensic proteomics is an expanding novel purpose in the aim of successfully quantifying biological estimations used in medico-legal investigations with greater accuracy. In this project, different extraction protocols were tested on n=30 human bone samples, includi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-10 | MSV000093803 | MassIVE
TranscriptomicsUncovering the Molecular Logic of Cortical Wiring between Neuronal subtypes Across Development Through Ligand–Receptor Inference
The cerebral cortex comprises diverse excitatory and inhibitory neuron subtypes, each with distinct laminar positions and connectivity patterns. Yet, the molecular logic underlying their precise wiring remains poorly understood. To identify ligand–receptor (LR) interactions involved in cortical circ...
ORGANISM(S): Mus musculus 
2026-01-30 | E-MTAB-16260 | biostudies-arrayexpress
TranscriptomicsNovel Regulators of Fgf23 Expression and Mineralization in Hyp Bone
We used gene array analysis of cortical bone to identify Phex-dependent gene transcripts regulating Fgf23 production and mineralization in Hyp mice. We discovered that activation of Fgf receptor- and Wnt-pathways contribute to increased Ffg23 gene transcription in Hyp bone. We found evidence in Hyp ...
ORGANISM(S): Mus musculus 
2009-12-21 | E-GEOD-14242 | biostudies-arrayexpress
TranscriptomicsSingle-nucleus data for Uncovering the Molecular Logic of Cortical Wiring between Neuronal subtypes Across Development Through Ligand–Receptor Inference
The cerebral cortex comprises diverse excitatory and inhibitory neuron subtypes, each with distinct laminar positions and connectivity patterns. Yet, the molecular logic underlying their precise wiring remains poorly understood. To identify ligand–receptor (LR) interactions involved in cortical circ...
ORGANISM(S): Mus musculus 
2025-12-14 | E-MTAB-16355 | biostudies-arrayexpress
TranscriptomicsExpression data from hypervitaminosis A rat diaphyseal bone
Vitamin A is the only known compound that produces spontaneous fractures in rats. In an effort to resolve the molecular mechanism behind this effect, we fed young rats high doses of vitamin A and performed a global transcriptional analysis of diaphyseal bone after one week, i.e. just before the firs...
ORGANISM(S): Rattus norvegicus 
2011-12-21 | E-GEOD-29859 | biostudies-arrayexpress
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