Sort   by:  
 Page size 
ProteomicsIntact mass spectrometry analysis of covalent binding between purified recombinant human FGFR2 V564F protein and small-molecule compound LC-F2-1 incubated at a molar ratio of 1:2 or 1:5 at room temperature via Agilent 6230 time-of-flight LC/MS system for the characterization of their covalent binding products in protein-drug interaction studies
This dataset corresponds to an intact mass spectrometry study focusing on the covalent binding interaction between purified FGFR2 V564F protein and compound LC-F2-1. The purified FGFR2 V564F was adjusted to 28 μM, then incubated with LC-F2-1 at molar ratios of 1:2 or 1:5 for 4 hours at room temperat...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD073416 | Pride
Covalent binding Lc-ms Lc-f2-1 Fgfr2 v564f 
TranscriptomicsThe minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus.
Objectives The antistaphylococcal pyrrolobenzodiazepine dimer ELB-21 forms multiple adducts with duplex DNA through covalent interactions with appropriately spaced guanine residues; it is now known to form interstrand and intrastrand adducts with oligonucleotide sequences of variable length. We dete...
ORGANISM(S): Staphylococcus aureus 
2011-04-15 | E-BUGS-115 | biostudies-arrayexpress
UnknownTechnologies for Direct Detection of Covalent Protein-Drug Adducts.
Not available
S-EPMC10146396 | biostudies-literature
GenomicsDNA-Protein Crosslink sequencing (DPC-seq) in RPE-1 cells treated with formaldehyde
Covalent DNA-protein crosslinks (DPC) are toxic DNA lesions that require repair by global-genome and replication-coupled pathways. How cells respond when RNA polymerases stall at DPCs during transcription is unknown. DPC-seq is new method for the genome-wide mapping of covalent DNA-protein adducts.
ORGANISM(S): Homo sapiens 
2024-02-24 | E-MTAB-12912 | biostudies-arrayexpress
ProteomicsIdentification of histone adducts with glycidamide
Identification of protein covalent modifications (adducts) is a challenging task mainly due to the lack of data processing approaches for Adductomics studies. We report a novel strategy to identify covalently modified peptides that consists on LC-MS data preprocessing followed by statistical analysi...
ORGANISM(S): Homo sapiens (Human) 
2019-07-25 | PXD013683 | Pride
Histones Mass spectrometry Glycidamide Adductomics 
ProteomicsDetection and Quantification of Drug-Protein Adducts in Human Liver
Protein adducts formed by drugs or their reactive metabolites are risk factors for adverse reactions, toxicity and inactivation of cytochrome P450 (CYP) enzymes. Characterization of drug-protein adducts is limited due to lack of methods capable of discovering the proteins and peptides adducted by re...
ORGANISM(S): Homo Sapiens Spodoptera Frugiperda 
2024-10-25 | PXD054246 | panorama
UnknownCovalent adducts formed by the androgen receptor transactivation domain and small molecule drugs remain disordered.
Not available
S-EPMC11601358 | biostudies-literature
UnknownCovalent Adducts Formed by the Androgen Receptor Transactivation Domain and Small Molecule Drugs Remain Disordered.
Not available
S-EPMC12199303 | biostudies-literature
UnknownDetection and Quantification of Drug-Protein Adducts in Human Liver.
Not available
S-EPMC11537226 | biostudies-literature
UnknownTreatment of human cells with 5-aza-dC induces formation of PARP1-DNA covalent adducts at genomic regions targeted by DNMT1.
Not available
S-EPMC7669653 | biostudies-literature
Sort   by:  
 Page size