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MetabolomicsCreatine uptake promotes dendritic cell activation and enhances antitumor immunity

Dendritic cells (DCs) are central regulators of antitumor T cell immunity and are highly sensitive to metabolic cues. However, the therapeutic potential of targeting DC metabolism remains underexplored. Here, we report upregulation of the creatine transporter (CrT; Slc6a8) in intratumora...

2026-03-11 | MTBLS12797 | MetaboLights
TranscriptomicsEffect of acute creatine monohydrate supplementation on skeletal muscle transcriptome
Expression profiling of vastus lateralis muscle of young, healthy, non-obese men supplemented with creatine monohydrate vs. placebo for 10 days. Results identify transcriptional pathways activated in skeletal muscles as a result of acute creatine monohydrate supplementation. Keywords: Supplementatio...
ORGANISM(S): Homo sapiens 
2010-06-11 | E-GEOD-7877 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brains from mice fed with or without creatine supplementation to study the molecular mechanism of creatine improving health and life span in mice
Here we show that oral creatine (Cr) supplementation leads to increased life span in mice. Treated mice showed improved neurobehavioral performance, decreased accumulation of the aging pigment lipofuscin and upregulation of anti-aging genes in brain. As Cr is virtually free of adverse effects, it ma...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5140 | biostudies-arrayexpress
ProteomicsBrain Creatine Kinase as a biomarker for Alzheimer’s disease
The creatine-phosphocreatine cycle serves as a crucial temporary energy buffering system in the brain, regulated by brain creatine kinase (CKB). CKB, responsible for reversible phosphorylation of creatine, plays a pivotal role in maintaining ATP levels. Alzheimer's disease (AD) has been linked to in...
ORGANISM(S): Homo Sapiens 
PXD050060 | panorama
TranscriptomicsGene array experiment to identify genes that are upregulated by saturating creatine levels in vitro and potentially inhibiting creatine transporter (CrT) activity
We sought to investigate the mechanisms of CrT modulation by saturating extracellular Cr. For this purpose, we used an in vitro system of 3T3 fibroblasts stably overexpressing CrT and followed a global gene array approach to test the hypothesis that saturating intracellular [Cr] increases the expres...
ORGANISM(S): Mus musculus 
2012-12-07 | E-GEOD-42356 | biostudies-arrayexpress
ProteomicsSLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer
To explore whether creatine regulates iron death sensitivity in colorectal cancer by modulating the function of certain proteins, we performed immunoprecipitation experiments with biotin-labelled creatine and conducted proteomics studies on these IP-down proteins.
ORGANISM(S): Homo sapiens (Human) 
2025-09-06 | PXD061637 | Pride
Tumor metabolic reprogramming  ferroptosis  creatine  immunotherapy 
TranscriptomicsCardiac muscle ring finger-1 increases susceptibility to heart failure by inhibiting creatine kinase activity in vivo
Muscle ring finger-1 (MuRF1) is a muscle-specific protein implicated in the regulation of cardiac myocyte size and contractility. MuRF2, a closely related family member, redundantly interacts with protein substrates, and hetero-dimerizes with MuRF1. Mice lacking either MuRF1 or MuRF2 are phenotypica...
ORGANISM(S): Mus musculus 
2009-06-03 | E-GEOD-11661 | biostudies-arrayexpress
ProteomicsProteomes of human brain organoids derived from individuals with creatine transporter deficiency
Next-generation proteomics of human brain organoids derived from individuals with creatine transporter deficiency in order to assess their characteristics as models of the pathophysiology.
ORGANISM(S): Homo sapiens (Human) 
2023-10-12 | PXD040185 | Pride
Brain organoids Neuroscience Creatine transporter deficiency Proteomics Genetic disease Molecular pathways 
TranscriptomicsComprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis
Besides being building blocks for protein synthesis, amino acids serve a wide variety of cellular functions, including acting as metabolic intermediates for ATP generation and for redox homeostasis. Upon amino acid deprivation, free uncharged tRNAs trigger GCN2-ATF4 to mediate the well-characterized...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-62673 | biostudies-arrayexpress
GenomicsMetabolic reprogramming of macrophage polarization by creatine [RNA-seq]
Metabolic reprogramming of macrophage polarization by creatine [RNA-seq]
PRJNA433621 | ENA
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