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MetabolomicsCross-kingdom synthetic microbiota suppresses wheat Fusarium crown rot by remodeling the rhizosphere microbiome and metabolome

Wheat is a major staple crop grown across the globe. Fusarium crown rot (FCR) of wheat, caused by Fusarium pseudograminearum, is a destructive soil-borne disease that lacks effective sustainable control measures. Here, we assembled a cross-kingdom synthetic microbial community (SMC) comprising Tr...

2025-09-06 | MTBLS12946 | MetaboLights
MetabolomicsGut fungal landscape in colorectal cancer and its cross-kingdom interplay with gut microbial ecology

Background: The gut microbiota is a key hallmark of tumor and plays a central role in colorectal cancer (CRC). However, the contribution of gut fungi, an important community of gut microbes, remains substantially understudied in CRC.

Objective: To characterize the gut fungal landscape in CR...

2025-07-26 | MTBLS12776 | MetaboLights
MetabolomicsWild soybean rhizosphere microbiomes buffer continuous cropping obstacles in cultivated soybean via functional cross-kingdom synthetic communities

A cross-kingdom synthetic community (SSC) derived from wild soybean rhizosphere soil was constructed and inoculated onto cultivated soybeans suffering from continuous cropping obstacles. Root exudates from cultivated soybeans were collected before and after inoculation with the SSC via a hydropon...

2026-03-14 | MTBLS13803 | MetaboLights
MetabolomicsCross-modal Integration of Metabolomics and Cardiac Functionality Captures Dynamic Metabotoxic Effects of Doxorubicin in Engineered Heart Tissues

Functional stem cell-derived heart models offer new avenues for preclinical, animal-free physiological assessment of drug cardiotoxicity. Yet, comprehensive molecular profiling in these models remains limited, leaving key metabolic drivers of cardiotoxicity unexplored.

Here, we leveraged an...

2025-12-07 | MTBLS13225 | MetaboLights
GenomicsOral cross-kingdom biofilm
Oral cross-kingdom biofilm Raw sequence reads
PRJNA434579 | ENA
Genomicscross-kingdom oral biofilm
Bacterial-derived exopolysaccharides enhance antifungal drug tolerance in a cross-kingdom oral biofilm
PRJEB25195 | ENA
ProteomicsQuantitative cross-linking/mass spectrometry
Dynamic proteins and multi-protein complexes govern most biological processes. Cross-linking/mass spectrometry (CLMS) is increasingly successful in providing residue- resolution data on static proteinaceous structures. Here we investigate the technical feasibility of recording dynamic processes usin...
ORGANISM(S): Homo sapiens (Human) 
2015-06-08 | PXD002142 | Pride
Protein dynamics Structual biology Quantitation Cross-linking 
MetabolomicsSynthetic Microbial Communities Improve Wheat Stem Base Rot and Promote Wheat Growth by Regulating Rhizosphere Microbial Communities

Background

Wheat crown rot (WCR) caused by Fusarium spp. lacks durable, sustainable control. Engineering the rhizosphere with defined synthetic microbial communities (SynComs) offers a route to combined disease suppression and growth promotion. We aimed to build a cross-kingdom SynCom and e...

2025-09-06 | MTBLS12945 | MetaboLights
ProteomicsOn the reproducibility of label-free quantitative cross-linking/mass spectrometry
Quantitative cross-linking/mass spectrometry (QCLMS) is an emerging approach to study conformational changes of proteins and multi-subunit complexes. Distinguishing protein conformations requires reproducibly identifying and quantifying cross-linked peptides. Here we analyzed the variation between m...
ORGANISM(S): Homo sapiens (Human) 
2018-01-02 | PXD007250 | Pride
Cross-linking Mass-spectrometry Skyline Quatitation 
ProteomicsA complimentary benzophenone cross-linking/mass spectrometry photochemistry
We introduce a complimentary, heterobifunctional, photoactivatable, benzophenone containing cross-linker and show its successful application to cross-linking/mass spectrometry, by increasing data density, when used alongside a previously developed diazirine-based heterobifunctional cross-linker.
ORGANISM(S): Homo sapiens (Human) 
2017-04-26 | PXD004920 | Pride
Cross-linking/mass spectrometry  high-density data  complimentary chemistry  protein chemistry  human serum albumin 
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