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GenomicsVprBP/DCAF1 triggers melanomagenic gene silencing through histone H2A phosphorylation
VprBP/DCAF1 triggers melanomagenic gene silencing through histone H2A phosphorylation
PRJNA961784 | ENA
ProteomicsIP-MS of DCAF1/VprBP interacting proteins in mouse CD4 T cells
DCAF1, also known as VprBP (HIV-1-viral-protein-r-binding-protein), is an evolutionary conserved substrate-binding subunit of CRL4 (Cul4a-Ddb1-Roc1) ubiquitin ligase complex. It is a cellular protein targeted by HIV-1 viral protein R (Vpr). DCAF1 modulates cellular response against HIV in macrophage...
ORGANISM(S): Mus musculus (Mouse) 
2016-01-12 | PXD003180 | Pride
Dcaf1 T cell Vprbp Hiv-1 
TranscriptomicsVprBP/DCAF1 triggers melanomagenic gene silencing through histone H2A phosphorylation
DCAF1, also known as VprBP, is a recently identified atypical kinase and plays an important role in downregulating the transcription of tumor suppressor genes as well as increasing the risk for colon and prostate cancers. Melanoma is the most aggressive form of skin cancer arising from pigment-produ...
ORGANISM(S): Homo sapiens 
2023-05-05 | GSE230573 | GEO
UnknownVprBP/DCAF1 Triggers Melanomagenic Gene Silencing through Histone H2A Phosphorylation.
Not available
S-EPMC10526264 | biostudies-literature
UnknownVprBP/DCAF1 regulates p53 function and stability through site-specific phosphorylation.
Not available
S-EPMC10121470 | biostudies-literature
UnknownVprBP/DCAF1 Regulates the Degradation and Nonproteolytic Activation of the Cell Cycle Transcription Factor FoxM1.
Not available
S-EPMC5472828 | biostudies-literature
GenomicsDiscovery and characterisation of VPRBP/DCAF1 kinase inhibitor analogues as microtubular destabilising agents with potent anti-myeloma activity
Discovery and characterisation of VPRBP/DCAF1 kinase inhibitor analogues as microtubular destabilising agents with potent anti-myeloma activity
PRJNA1256382 | ENA
UnknownPhosphorylation and stabilization of EZH2 by DCAF1/VprBP trigger aberrant gene silencing in colon cancer.
Not available
S-EPMC10110550 | biostudies-literature
UnknownDCAF1 (VprBP): emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptor.
Not available
S-EPMC6821201 | biostudies-literature
TranscriptomicsDiscovery and characterisation of VPRBP/DCAF1 kinase inhibitor analogues as microtubular destabilising agents with potent anti-myeloma activity
Multiple myeloma is a plasma cell malignancy that is susceptible to drugs targeting protein homeostasis such as thalidomide analogues and proteasome inhibitors. Thalidomide analogues modulate the activity of DDB1/CUL4 E3-ligase complexes to perturb substrate recognition and proteasomal degradation t...
ORGANISM(S): Homo sapiens 
2025-10-06 | GSE295791 | GEO
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