Sort   by:  
 Page size 
ProteomicsPASS00589 - Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen treated 3D liver microtissues
The data set repersents a fair comparison of shotgun proteomics with HRM (swath type DIA). Additionally, a human liver microtissue was profiled with HRM.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-12-19 | MSV000081828 | MassIVE
ProteomicsProteomic profiling of human prostate cancer-associated fibroblasts identifies LOXL2 as a key regulator or pro-tumourigenic extracellular matrix
Whole proteome and phosphoproteomic analysis was performed on patient derived fibroblasts from benign and malignant sections of prostate tumour (n=4) using hyper reaction monitoring (HRM)- data-independent analysis (DIA) using Spectroanut 8 software.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-04-25 | MSV000082309 | MassIVE
ProteomicsDictyostelium DIA LFQ proteomics of vegetative and developmental growth
Dictyostelium discoideum behavior depends on nutrients. When sufficient food is present these amoebae exist in a unicellular state (vegetative growth), but upon starvation they aggregate into a multicellular organism (developmental growth). For proteomics 30 minutes and eight hour cultures of D. dis...
ORGANISM(S): Dictyostelium discoideum (Slime mold) 
2021-03-23 | PXD023404 | Pride
Dictyostelium discoideum  non-starved (vegetative)  starved (developmental)  dia hyper reaction monitoring  spectronaut  sulfur metabolism  reactive oxygen species 
UnknownExtending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen-treated three-dimensional liver microtissues.
Not available
S-EPMC4424408 | biostudies-literature
ProteomicsProteomic profiling of human prostate cancer-associated fibroblasts identifies LOXL2 promotes tumour migration in the extracellular matrix
In prostate cancer (PC), cancer-associated fibroblasts (CAFs) exhibit contrasting biological properties to non-malignant prostate fibroblasts (NPFs) and promote tumorigenesis. Resolving intercellular signaling pathways between CAFs and prostate tumor epithelium may offer novel opportunities for rese...
ORGANISM(S): Homo sapiens (Human) 
2019-05-24 | PXD010611 | Pride
Phosphoproteome Fibroblast Loxl2 Prostate cancer 
UnknownProteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment.
Not available
S-EPMC6601211 | biostudies-literature
ProteomicsElenbecestat and compound 89 potently inhibit BACE1 but not BACE2 when subchronically dosed in non-human primates
The beta-secretase BACE1 (beta-site amyloid precursor (APP)-cleaving enzyme 1) is a major drug target for Alzheimer’s disease (AD), as it catalyzes the first step in amyloid beta (Abeta) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical tr...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-11-07 | PXD067413 | Pride
Proteomics Csf Bace1 inhibition Nhp Lc-ms/ms 
ProteomicsElenbecestat and compound 89 potently inhibit BACE1 but not BACE2 when subchronically dosed in non-human primates
The beta-secretase BACE1 (beta-site amyloid precursor (APP)-cleaving enzyme 1) is a major drug target for Alzheimer’s disease (AD), as it catalyzes the first step in amyloid beta (Abeta) generation, but has additional substrates and functions, in particular in the brain. Several advanced clinical tr...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2025-11-07 | PXD067461 | Pride
Proteomics Csf Bace1 inhibition Nhp Lc-ms/ms 
UnknownIdentification of Novel Response and Predictive Biomarkers to Hsp90 Inhibitors Through Proteomic Profiling of Patient-derived Prostate Tumor Explants.
Not available
S-EPMC6072547 | biostudies-literature
ProteomicsMultifaceted stoichiometry control of bacterial operons revealed by data-independent acquisition mass spectrometry
Genes clustered into polycistronic operons was thought a characteristic of bacteria and many other species. More than half protein-coding genes are organized in polycistronic operons composed of two or more than ten genes in bacterial genomes. Although the structure of operons have been studied prec...
ORGANISM(S): Escherichia coli 
2019-11-12 | PXD010126 | Pride
Operons Mass spectrometry Faceted stoichiometry control 
Sort   by:  
 Page size