Sort   by:  
 Page size 
ProteomicsItch Ubiquitin Ligase Deficiency and B cell LC-MSMS
The E3 ubiquitin ligase Itch regulates antibody levels and prevents autoimmune disease in humans and mice, yet how Itch regulates B cell fate or function is unknown. We now show that Itch directly limits B cell activity. Using LC-MSMS, we profiled and compared the whole cell proteomes of Itch defici...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-12 | PXD014243 | Pride
Itch ubiquitin ligase Lc-msms Tlr9 B cell 
TranscriptomicsRNA-seq of splenic B cells derived from WT and Itch cKO mice
We found that the E3 ubiquitin ligase Itch significantly affects early B-cell differentiation. To explore the role of Itch in late B-cell differentiation, we sorted B cells from WT and Itch cKO mice. To explore the effect of Itch deficency on gene expression, we determined mRNA profiles in B cells ...
ORGANISM(S): Mus musculus 
2020-03-01 | E-MTAB-8281 | biostudies-arrayexpress
TranscriptomicsRNA-seq of splenic B cells derived from WT and Itch KO mice
We found that the E3 ubiquitin ligase Itch significantly affects early B-cell differentiation. To explore the role of Itch in late B-cell differentiation, we sorted B cells from WT and Itch KO mice. To explore the effect of Itch deficency on gene expression, we determined mRNA profiles in B cells f...
ORGANISM(S): Mus musculus 
2020-03-01 | E-MTAB-8273 | biostudies-arrayexpress
UnknownPhosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase.
Not available
S-EPMC5777250 | biostudies-literature
UnknownATM kinase activity modulates ITCH E3-ubiquitin ligase activity.
Not available
S-EPMC3938399 | biostudies-literature
UnknownHuman ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease.
Not available
S-EPMC2833372 | biostudies-literature
UnknownUbiquitin E3 ligase Itch negatively regulates osteoblast function by promoting proteasome degradation of osteogenic proteins.
Not available
S-EPMC5376659 | biostudies-literature
UnknownItch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected].
Not available
S-EPMC3064387 | biostudies-literature
UnknownThe E3 ubiquitin ligase Itch restricts antigen-driven B cell responses.
Not available
S-EPMC6719427 | biostudies-literature
UnknownThe E3 ubiquitin ligase Itch is required for B-cell development.
Not available
S-EPMC6344599 | biostudies-literature
Sort   by:  
 Page size