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MetabolomicsMicrobiome Metabolism of Dietary Phytochemicals Controls the Anticancer Activity of PI3K Inhibitors
Phosphatidylinositol 3-kinase (PI3K) signaling is both the effector pathway of insulin and among the most frequently activated pathways in human cancer. In murine cancer models, the efficacy of PI3K inhibitors is dramatically enhanced by a ketogenic diet, with a proposed mechanism involving dietary ...
2025-03-26 | MTBLS10944 | MetaboLights
MetabolomicsLimited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. In pancreatic cancer cells, a cytosolic metabolic enzyme, wild-type isocitrate dehydrogenase 1 (wtIDH1), enables the adaptation to these co...

2022-04-29 | MTBLS4722 | MetaboLights
MetabolomicsSerine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

2025-03-21 | MTBLS8854 | MetaboLights
MetabolomicsThe lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression
Abnormalities in ether lipid metabolism as well as the formation of neutrophil extracellular traps have recently been recognized as detrimental factors affecting tumorigenesis and progression. However, the role of abnormal ether lipid metabolism in colorectal cancer (CRC) evolution has not been repo...
2024-10-01 | MTBLS10323 | MetaboLights
MetabolomicsInhibition of jasmonic acid-isoleucine conjugating enzyme JAR1 shifts the local and systemic leaf signals and metabolic profiles in Arabidopsis

• Jasmonates (JAs)-mediated pathways are central signaling hubs in plant defense responses. However, the identification of mobile and non-mobile signals involved in downstream systemic signaling is still less studied.

• Here, we investigate the role of the jasmonic acid-isoleucine conjugati...

2026-03-31 | MTBLS14117 | MetaboLights
ProteomicsOn-board Preconcentration Microchip Capillary Electrophoresis Based TMT-PRM-LIVE for High-throughput Selectivity Profiling of Deubiquitinase Inhibitors
On-board Preconcentration Microchip Capillary Electrophoresis Based TMT-PRM-LIVE for High-throughput Selectivity Profiling of Deubiquitinase Inhibitors
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-24 | MSV000089122 | MassIVE
TranscriptomicsUltrahigh-throughput discovery of modified aptamers as specific and potent enzyme inhibitors
Enzymes are instrumental to life and key actors of pathologies, making them relevant drug targets. Most enzyme inhibitors consist of small molecules. Although efficient, their development is long, costly and can come with unwanted off-targeting. Substantial gain in specificity and discovery efficien...
ORGANISM(S): synthetic construct 
2024-09-15 | E-MTAB-14407 | biostudies-arrayexpress
GenomicsUltrahigh-throughput discovery of modified aptamers as specific and potent enzyme inhibitors
Ultrahigh-throughput discovery of modified aptamers as specific and potent enzyme inhibitors
PRJEB79572 | ENA
ProteomicsDual-acting IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance
Isoprenoids are vital to all organisms in supporting core functions of life, like respiration and membrane stability. IspH, an enzyme in the methyl erythritol phosphate pathway of isoprenoid synthesis, is essential to gram-negative bacteria, mycobacteria and apicomplexans. The IspH substrate, HMBPP,...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-10-22 | MSV000086359 | MassIVE
ProteomicsCytoplasmic capping enzyme interactome
Formaldehyde crosslinking and Proximity-dependent biotinylation methods were applied to study the cytoplasmic capping enzyme interactome via 1D-LC-MS/MS. The raw data were searched against Uniprot human database modified to contain our designed protein sequences using the Thermo Proteome Discoverer ...
ORGANISM(S): Homo Sapiens (human) 
PXD010368 | JPOST Repository
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