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TranscriptomicsERK1/2 in Ovarian Granulosa Cells are Essential for Female Fertility
A surge of luteinizing hormone (LH) from the pituitary gland triggers ovulation, oocyte maturation, and luteinization for successful reproduction in mammals. Since the signaling molecules RAS and ERK1/2 are activated by a LH surge in granulosa cells of preovulatory follicles, we disrupted Erk1/2 in ...
ORGANISM(S): Mus musculus 
2009-03-20 | E-GEOD-15315 | biostudies-arrayexpress
TranscriptomicsTPL-2;ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I interferon production [Set 2]
Analysis of Mtb infected murine macrophages derived from C57Bl/6 WT, TPL2KO, IFNARKO & TPL2IFNAR DKO mice [Set 2] Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality and morbidity worldwide, causing approximately 1.4 million deaths per year. Key immune com...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-47673 | biostudies-arrayexpress
TranscriptomicsDual-mechanism ERK1/2 inhibitors exploit a distinct binding mode to block phosphorylation and nuclear accumulation of ERK1/2, resulting in enhanced potency
Here we have characterized the MoA of Erk inhibitors in terms of Erk1/2 signalling, gene expression and antiproliferative efficacy in BRAF and RAS mutant cell lines.
ORGANISM(S): Homo sapiens 
2020-10-08 | E-MTAB-7959 | biostudies-arrayexpress
TranscriptomicsTPL-2;ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I interferon production [Set 1]
Analysis of Mtb infected murine macrophages derived from C57Bl/6 WT, TPL2KO, IFNARKO & TPL2IFNAR DKO mice [Set 1] Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality and morbidity worldwide, causing approximately 1.4 million deaths per year. Key immune comp...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-47672 | biostudies-arrayexpress
TranscriptomicsDepletion of Erk1 and Erk2 MAP kinases in primary human keratinocytes
We assessed the effect of RNAi-mediated MAP kinase cascade signaling blockade in primary human keratinocytes. Two sets of siRNA targeting different regions of the Erk1/2 genes were used, enabling identification of off-target siRNA effects. Primary human keratinocytes were electroporated with scra...
ORGANISM(S): Homo sapiens 
2009-05-03 | E-GEOD-15417 | biostudies-arrayexpress
ProteomicsSCAMP3-Driven Regulation of ERK1/2 and Autophagy Phosphoproteomics Signatures in Triple-Negative Breast Cancer
Despite the promise of ERK1/2 pathway inhibitors, their efficacy is often limited by feedback mechanisms and pathway adaptability, emphasizing the need to identify co-regulatory proteins that modulate ERK1/2 signaling. Previously, we identified secretory carrier membrane protein 3 (SCAMP3) as a key ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD064784 | Pride
Proteomics Scamp3  triple negative breast cancer  erk1/2  autophagy  akt/mtor 
GenomicsERK1/2-RNAseq_Owenia
The role of ERK1/2 during spiral cleavage in the annelid Owenia fusiformis
PRJEB47195 | ENA
GenomicsERK1/2 signaling and cortical interneuron development
ERK1/2 signaling and cortical interneuron development
PRJNA851625 | ENA
GenomicsRNA-sequencing analysis of mouse liver with a global ERK1, hepatocyte-specific ERK2 or double ERK1/2 knockout
RNA-sequencing analysis of mouse liver with a global ERK1, hepatocyte-specific ERK2 or double ERK1/2 knockout
PRJNA753503 | ENA
ProteomicsZSWIM1 promotes the proliferation and metastasis of lung adenocarcinoma cells through the STK38/MEKK2/ERK1/2 axis
Investigating the functions of the proteins with no or less functional annotations is an important goal of C-HPP (Chromosome-centric Human Proteome Project). In this study, we investigated the function of such a protein, ZSWIM1 (C20orf162). Its expression is upregulated in lung adenocarcinoma compar...
ORGANISM(S): Homo sapiens (Human) 
2023-01-04 | PXD035006 | Pride
Zswim1 Lung adenocarcinoma Migration Erk1/2 Stk38 Proliferation 
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