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ProteomicsStk38 interactomics by proximity ligation
STK38 (aka NDR1) is a Hippo pathway serine/threonine protein kinase with multifarious functions in normal and cancer cells. Using a context-dependent proximity labelling assay, we discovered that STK38 modulates its interaction with more than 250 proteins depending on the context. Upon starvation-in...
ORGANISM(S): Homo sapiens (Human) 
2019-09-26 | PXD011968 | Pride
Xpo1 Stk38 Apex 
ProteomicsZSWIM1 promotes the proliferation and metastasis of lung adenocarcinoma cells through the STK38/MEKK2/ERK1/2 axis
Investigating the functions of the proteins with no or less functional annotations is an important goal of C-HPP (Chromosome-centric Human Proteome Project). In this study, we investigated the function of such a protein, ZSWIM1 (C20orf162). Its expression is upregulated in lung adenocarcinoma compar...
ORGANISM(S): Homo sapiens (Human) 
2023-01-04 | PXD035006 | Pride
Zswim1 Lung adenocarcinoma Migration Erk1/2 Stk38 Proliferation 
GenomicsRegulation of STK38 by autophagy governs YAP1 activity during paligenosis
Regulation of STK38 by autophagy governs YAP1 activity during paligenosis
PRJNA1249027 | ENA
TranscriptomicsRegulation of STK38 by autophagy governs YAP1 activity during paligenosis
Paligenosis is a conserved process that enables mature cells to reenter the cell cycle in response to tissue injury, progressing through stages of autodegradation, gene expression changes, and proliferation. The Hippo signaling pathway, particularly YAP1, plays a key role in regulating this process,...
ORGANISM(S): Mus musculus 
2026-03-15 | GSE294328 | GEO
TranscriptomicsSTK38 is a Key Regulator of MYC Transcriptional Activity in Human B lymphoma cells
Post-translational regulation of the MYC Transcription Factor (TF), including its phosphorylation and ubiquitination, plays an important role in determining cell proliferation and apoptosis and has been implicated in tumorigenesis. Using a computational systems biology approach, followed by biochemi...
ORGANISM(S): Homo sapiens 
2012-01-06 | GSE20229 | GEO
UnknownSTK38 is a PPARγ-interacting protein promoting adipogenesis.
Not available
S-EPMC8726646 | biostudies-literature
TranscriptomicsSTK38 is a Key Regulator of MYC Transcriptional Activity in Human B lymphoma cells
Post-translational regulation of the MYC Transcription Factor (TF), including its phosphorylation and ubiquitination, plays an important role in determining cell proliferation and apoptosis and has been implicated in tumorigenesis. Using a computational systems biology approach, followed by biochemi...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-20229 | biostudies-arrayexpress
UnknownPrevention of calpain-dependent degradation of STK38 by MEKK2-mediated phosphorylation.
Not available
S-EPMC6831656 | biostudies-literature
UnknownStk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes.
Not available
S-EPMC5359592 | biostudies-literature
UnknownThe Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy.
Not available
S-EPMC4598746 | biostudies-literature
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