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ProteomicsXPO1 amplification abrogates the effects of E571K XPO1 mutation in B-cell lymphoma
XPO1 gene encodes exportin 1 (XPO1) that controls the nuclear export of cargo proteins and RNAs. Almost 25% of primary mediastinal B-cell lymphomas (PMBL) and classical Hodgkin lymphomas (cHL) cases harboured a recurrent XPO1 point mutation (NM_003400, chr2:g61718472C>T) resulting in the E571K modif...
ORGANISM(S): Homo sapiens (Human) 
2020-10-01 | PXD016916 | Pride
Ap-ms U2940 Xpo1 Human cells Exportin 1 K1106 primary mediastinal b-cell lymphomal lines Medb1 Q-exactive plus 
ProteomicsXPO1 is a critical player for Bortezomib resistance in Multiple Myeloma: A quantitative proteomic approach
Among the blood cancers, 13% mortality is caused by Multiple myeloma (MM) type of haematological malignancy. In spite of therapeutic advances in chemotherapy treatment, still MM remains an incurable disease is mainly due to emergence of chemoresistance. At present time, FDA approved bortezomib is th...
ORGANISM(S): Homo sapiens (Human) 
2019-09-09 | PXD013859 | Pride
Label free analysis Chemoresistance Bortezomib Xpo1 Multiple myeloma Itraq 
GenomicsXPO1-dependency of DEK::NUP214 leukemia sensitizes against eltanexor
XPO1-dependency of DEK::NUP214 leukemia sensitizes against eltanexor
PRJNA1126303 | ENA
ProteomicsThe nuclear export protein XPO1 provides a peptide ligand for natural killer cells
XPO1 is a nuclear export protein that is frequently overexpressed in cancer and functions as a driver of oncogenesis. Currently small molecules that target XPO1 are being used in the clinic as anti-cancer agents. We identify XPO1 as a target for natural killer (NK) cells. Using immunopeptidomics w...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD053264 | Pride
Natural killer cells Kir2ds2 Hla-c*0102 Huh7 cells Hepatocellular carcinoma 
GenomicsHigh-throughput mRNA sequencing of CLL cells containing an E571K XPO1 mutations
High-throughput mRNA sequencing of CLL cells containing an E571K XPO1 mutations
PRJNA685838 | ENA
GenomicsRNA sequencing of neuroblastoma cells treated with selinexor or with XPO1 knockdown
RNA sequencing of neuroblastoma cells treated with selinexor or with XPO1 knockdown
PRJNA741521 | ENA
ProteomicsStk38 interactomics by proximity ligation
STK38 (aka NDR1) is a Hippo pathway serine/threonine protein kinase with multifarious functions in normal and cancer cells. Using a context-dependent proximity labelling assay, we discovered that STK38 modulates its interaction with more than 250 proteins depending on the context. Upon starvation-in...
ORGANISM(S): Homo sapiens (Human) 
2019-09-26 | PXD011968 | Pride
Xpo1 Stk38 Apex 
GenomicsXPO1 R749Q Mutation Drives Endometrial Cancer Progression by Activating HIF-1/2α–AXL–PI3K/MAPK Signaling
XPO1 R749Q Mutation Drives Endometrial Cancer Progression by Activating HIF-1/2α–AXL–PI3K/MAPK Signaling
PRJNA1240244 | ENA
GenomicsBinding Changes in Chromatin Factors Upon Targeted XPO1 Inhibition in T Cells
Binding Changes in Chromatin Factors Upon Targeted XPO1 Inhibition in T Cells
PRJNA1022781 | ENA
GenomicsCancer -associated mutations in XPO1 transform cells through altered nuclear export signal recognition
Cancer -associated mutations in XPO1 transform cells through altered nuclear export signal recognition
PRJNA492253 | ENA
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