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ProteomicsSCAMP3-Driven Regulation of ERK1/2 and Autophagy Phosphoproteomics Signatures in Triple-Negative Breast Cancer
Despite the promise of ERK1/2 pathway inhibitors, their efficacy is often limited by feedback mechanisms and pathway adaptability, emphasizing the need to identify co-regulatory proteins that modulate ERK1/2 signaling. Previously, we identified secretory carrier membrane protein 3 (SCAMP3) as a key ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD064784 | Pride
Proteomics Scamp3  triple negative breast cancer  erk1/2  autophagy  akt/mtor 
ProteomicsIdentification of proteome changes in absence of secretory carrier associated membrane protein 3 (SCAMP3)
The membrane protein secretory carrier associated membrane protein 3 (SCAMP3) belongs to the family of SCAMP proteins. SCAMP3 is ubiquitously expressed and distributed in almost all cell membranes, especially in the trans Golgi network and the endolysosomal system. SCAMP3 has been shown to play a ro...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-08 | PXD062228 | Pride
Secretory carrier associated membrane protein 3  innate immunity  neutrophils  granules 
ProteomicsSCAMP3 is a component of insulin granules in MIN6 -cells and regulates insulin secretion and content
Pancreatic -cells in the islets of Langerhans are key to maintaining glucose homeostasis, by secreting the peptide hormone insulin. Insulin is packaged within vesicles named insulin secretory granules (ISGs), that have recently been considered to have intrinsic structures and proteins that regulate ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD051136 | Pride
Pancreas Beta cell Insulin Scamp3 Islet 
UnknownSCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling.
Not available
S-EPMC2655259 | biostudies-literature
UnknownSCAMP3 is a mutant EGFR phosphorylation target and a tumor suppressor in lung adenocarcinoma.
Not available
S-EPMC8514158 | biostudies-literature
UnknownMicroRNA-27a/b-3p and PPARG regulate SCAMP3 through a feed-forward loop during adipogenesis.
Not available
S-EPMC6761119 | biostudies-literature
UnknownSCAMP3-Driven Regulation of ERK1/2 and Autophagy Phosphoproteomics Signatures in Triple-Negative Breast Cancer.
Not available
S-EPMC12525412 | biostudies-literature
UnknownSCAMP3 Regulates EGFR and Promotes Proliferation and Migration of Triple-Negative Breast Cancer Cells through the Modulation of AKT, ERK, and STAT3 Signaling Pathways.
Not available
S-EPMC9179572 | biostudies-literature
UnknownSCAMP3 is a component of the Salmonella-induced tubular network and reveals an interaction between bacterial effectors and post-Golgi trafficking.
Not available
S-EPMC2730479 | biostudies-literature
ProteomicsBLTP2 bridges the ER and MVB for exosome biogenesis at SCAMP3-dependent ER contacts
Multivesicular bodies (MVBs) contain intraluminal vesicles (ILVs) designated for degradation in lysosomes or release as exosomes for cell-to-cell communication. The mechanisms governing ILV/exosome formation are not fully understood. Here, we show that the integral endoplasmic reticulum (ER) membran...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD081583 |
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