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GenomicsERK3 is essential for establishment of epithelial architecture [ERK3 KD]
ERK3 is essential for establishment of epithelial architecture [ERK3 KD]
PRJNA433711 | ENA
GenomicsERK3 is essential for establishment of epithelial architecture [ERK3 KD vs. TFAP2A KD]
ERK3 is essential for establishment of epithelial architecture [ERK3 KD vs. TFAP2A KD]
PRJNA433712 | ENA
ProteomicsPhosphoproteomic analysis identifies supervillin as a new ERK3 substrate regulating cytokinesis and ploidy of breast cancer cells
Extracellular signal-regulated kinase 3 (ERK3) is a poorly characterized member of the mitogen-activated protein (MAP) kinase family. Functional analysis of the ERK3 signaling pathway has been hampered by a lack of knowledge about the substrates and downstream effectors of the kinase. Here, we used ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-21 | PXD028061 | Pride
Breast cancer Cytokinesis Supervillin Erk3 Ploidy Phosphoprotoemic 
TranscriptomicsERK3 is essential for establishment of epithelial architecture [ERK3 KD]
Establishment and maintenance of epithelial architecture are essential for embryonic development and adult physiology. Here, we show that ERK3, a poorly characterized atypical MAPK, regulates epithelial architecture in vertebrates. In Xenopus embryonic epidermal epithelia, ERK3 knockdown impairs adh...
ORGANISM(S): Xenopus laevis 
2018-06-13 | GSE110427 | GEO
TranscriptomicsERK3 is essential for establishment of epithelial architecture [ERK3 KD vs. TFAP2A KD]
Establishment and maintenance of epithelial architecture are essential for embryonic development and adult physiology. Here, we show that ERK3, a poorly characterized atypical MAPK, regulates epithelial architecture in vertebrates. In Xenopus embryonic epidermal epithelia, ERK3 knockdown impairs adh...
ORGANISM(S): Xenopus laevis 
2018-06-13 | GSE110428 | GEO
GenomicsAdrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation
Adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation
PRJNA597001 | ENA
ProteomicsIntracellular pH regulates the ubiquitin-mediated degradation of the atypical MAP kinase ERK3
The atypical mitogen-activated protein kinase ERK3 is known for its instability and degradation via the ubiquitin-proteasome system (UPS). However, the specific environmental factors regulating ERK3 turnover have remained unclear. In this study, we demonstrate that intracellular pH (pHi) plays a cru...
ORGANISM(S): Homo sapiens (Human) 
2025-10-07 | PXD056239 | Pride
Map kinases  erk3  ph  protein stability 
GenomicsErk3 deletion drives oxidative adaptations in skeletal muscle
Erk3 deletion drives oxidative adaptations in skeletal muscle
PRJNA1425585 | ENA
GenomicsERK3-MK5 signaling regulates myogenic differentiation and muscle regeneration by promoting FoxO3 degradation
ERK3-MK5 signaling regulates myogenic differentiation and muscle regeneration by promoting FoxO3 degradation
PRJNA785591 | ENA
UnknownScaffolding by ERK3 regulates MK5 in development.
Not available
S-EPMC535084 | biostudies-literature
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