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ProteomicsCharacterization of ESX-1 components EccA1, EspG1 and EspH reveal pivotal role of Esp substrates in the Mycobacterium marinum infection cycle
The pathogen Mycobacterium tuberculosis employs a range of ESX-1 substrates to manipulate the host and build a successful infection. Although the importance of ESX-1 secretion in virulence is well established, the characterization of its individual components and the role of individual substrates is...
ORGANISM(S): Mycobacterium marinum ATCC BAA-535 
2018-08-02 | PXD008905 | Pride
Esx-1 Secretion Label-free quantitation Ecca1  espg1  esph  esxa Mycobactrium marinum 
UnknownThe ubiquitin system targets translocated EspH to proteasomal degradation.
Not available
S-EPMC12688225 | biostudies-literature
UnknownEspH Suppresses Erk by Spatial Segregation from CD81 Tetraspanin Microdomains.
Not available
S-EPMC6204722 | biostudies-literature
UnknownEspH interacts with the host active Bcr related (ABR) protein to suppress RhoGTPases.
Not available
S-EPMC9559323 | biostudies-literature
UnknownEspH utilizes phosphoinositide and Rab binding domains to interact with plasma membrane infection sites and Rab GTPases.
Not available
S-EPMC11421376 | biostudies-literature
UnknownThe enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP).
Not available
S-EPMC4977065 | biostudies-literature
UnknownThe interplay between the Escherichia coli Rho guanine nucleotide exchange factor effectors and the mammalian RhoGEF inhibitor EspH.
Not available
S-EPMC3374388 | biostudies-literature
UnknownEspL is essential for virulence and stabilizes EspE, EspF and EspH levels in Mycobacterium tuberculosis.
Not available
S-EPMC6319747 | biostudies-literature
UnknownEspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF.
Not available
S-EPMC6107294 | biostudies-literature
ProteomicsespL deletion mutant of Mycobacterium tuberculosis
The ESX-1, type VII, secretion system represents the major virulence determinant of Mycobacterium tuberculosis, one of the most successful intracellular pathogens. Here, by combining genetic and high-throughput approaches, we show that EspL, a protein of 115 amino acids, is essential for mediating E...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2018-12-10 | PXD010929 | Pride
Mycobacterium Virulence Tuberculosis Espl 
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