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ProteomicsProteolytic-independent role of mycosins in stabilization of the ESX-1 and ESX-5 type VII secretion membrane complexes.
Pathogenic mycobacteria contain up to five type VII secretion (T7S) systems, ESX-1 to ESX-5, which have central roles in virulence and viability. One of the conserved components of these systems, the serine protease mycosin (MycP), has been shown to be essential for secretion by ESX-1 and ESX-5. How...
ORGANISM(S): Mycobacterium marinum ATCC BAA-535 
2016-10-11 | PXD003766 | Pride
Mycobacterium marinum Tuberculosis Esx1 Single-shot Esx5 Label-free T7s 
ProteomicsCharacterization of ESX-1 components EccA1, EspG1 and EspH reveal pivotal role of Esp substrates in the Mycobacterium marinum infection cycle
The pathogen Mycobacterium tuberculosis employs a range of ESX-1 substrates to manipulate the host and build a successful infection. Although the importance of ESX-1 secretion in virulence is well established, the characterization of its individual components and the role of individual substrates is...
ORGANISM(S): Mycobacterium marinum ATCC BAA-535 
2018-08-02 | PXD008905 | Pride
Esx-1 Secretion Label-free quantitation Ecca1  espg1  esph  esxa Mycobactrium marinum 
GenomicsDual RNA-Seq Uncovers ESX-1- and ESX-5-Dependent Virulence Programs of Mycobacterium marinum in Human and Murine Macrophages
Dual RNA-Seq Uncovers ESX-1- and ESX-5-Dependent Virulence Programs of Mycobacterium marinum in Human and Murine Macrophages
PRJEB100678 | ENA
TranscriptomicsTranscription profiling of Mycobacterium bovis with pYUB412 and pRD1-2F9 genes knocked-in to investigate the ESX-1 secretion system
The dedicated secretion system ESX-1 of Mycobacterium tuberculosis encoded by the extended RD1 region (extRD1) assures export of the ESAT-6 protein and its partner, the 10 kDa culture filtrate protein CFP-10, and is missing from the vaccine strains M.bovis BCG and M.microti. Here, we systematically ...
ORGANISM(S): Mycobacterium bovis 
2007-01-30 | E-BUGS-31 | biostudies-arrayexpress
TranscriptomicsThe carbonic anhydrase inhibitor ethoxzolamide inhibits the Mycobacterium tuberculosis PhoPR regulon and Esx-1 secretion and attenuates virulence
The purpose of this study was to examine how ethoxzolamide modulates gene M. tuberculosis gene expression at acidic pH. We observed that ethoxzolamide downregulates genes of the PhoPR regulon. Mtb strain CDC1551 was grown at 37C in T-25 vented, standing tissue culture flasks in 8 ml of buffered 7H9 ...
ORGANISM(S): Mycobacterium tuberculosis 
2015-05-20 | E-GEOD-63917 | biostudies-arrayexpress
TranscriptomicsGene expression profile of M.tuberculosis espR (Rv3849) mutant
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-07-04 | E-GEOD-11696 | biostudies-arrayexpress
TranscriptomicsWhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinum
WhiB6 is a transcription factor that regulates expression of genes encoding ESX-1 substrates. We found that in the absence of the genes encoding conserved membrane components of the ESX-1 system, the expression of the whiB6 gene and genes encoding ESX-1 substrates were reduced.
ORGANISM(S): Mycobacterium marinum 
2017-11-27 | GSE99632 | GEO
GenomicsWhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteria
WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteria
PRJNA511673 | ENA
TranscriptomicsWhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteria
These data show that WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates and ESX-1 substrates are regulated independently from the structural components, both during infection and as a result of active secretion.
ORGANISM(S): Mycobacterium tuberculosis H37Rv Mycobacterium marinum M Mycobacterium marinum E11 
2018-12-25 | GSE124341 | GEO
UnknownStructural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems.
Not available
S-EPMC6331215 | biostudies-literature
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