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ProteomicsIQCN disruption causes fertilization failure and male infertility due to manchette assembly defect
Total fertilization failure (TFF) is an important cause of infertility; however, the genetic basis of TFF caused by male factors remain to be clarified. In this study, whole-exome sequencing was firstly used to screen for genetic causes of TFF after intracytoplasmic sperm injection (ICSI), and homoz...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-22 | PXD036197 | Pride
Iqcn  manchette  fertilization failure 
Proteomics,MultiomicsComplementary critical functions of Zfy1 and Zfy2 in mouse spermatogenesis and reproduction
The mammalian Y chromosome plays a critical role in spermatogenesis. However, the exact functions of each gene in the Y chromosome have not been completely elucidated, partly owing to difficulties in gene targeting analysis of the Y chromosome. Zfy was first proposed to be a sex determination factor...
ORGANISM(S): Mus <mouse, Genus> (ncbitaxon:10088) 
2016-11-24 | MSV000080355 | MassIVE
TranscriptomicsFunctional diversity and convergence of small non-coding RNAs in male germ cell differentiation and fertilization (piRNA and endo-siRNAs)
The small non-coding RNAs (sncRNAs) are considered as postranscriptional key regulators of male germ cell development. In addition to microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), other sncRNAs generated from small nucleolar RNAs (snoRNAs), tRNAs or rRNAs processing may also play important ...
ORGANISM(S): Mus musculus 
2015-03-26 | E-GEOD-59254 | biostudies-arrayexpress
GenomicsUnraveling the Molecular Mechanisms of Total Fertilization Failure: Insights into Transcriptional Dysregulation
Unraveling the Molecular Mechanisms of Total Fertilization Failure: Insights into Transcriptional Dysregulation
PRJNA1221880 | ENA
Genomics
Recurrent Fertilization Failure After ICSI
PRJNA1248732 | ENA
UnknownMutational analysis of IZUMO1R in women with fertilization failure and polyspermy after in vitro fertilization.
Not available
S-EPMC5904069 | biostudies-literature
UnknownTotal fertilization failure with in vitro fertilization-intracytoplasmic sperm injection related to WEE2 mutation highlights emerging importance of genetic causes of in vitro fertilization failure.
Not available
S-EPMC9783144 | biostudies-literature
UnknownGene mutations associated with fertilization failure after in vitro fertilization/intracytoplasmic sperm injection.
Not available
S-EPMC9800785 | biostudies-literature
UnknownHomozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility.
Not available
S-EPMC5985286 | biostudies-literature
UnknownNovel WEE2 compound heterozygous mutations identified in patients with fertilization failure or poor fertilization.
Not available
S-EPMC8608989 | biostudies-literature
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