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ProteomicsPhosphoproteomics of truncated FGFR2, a clinically actionable oncogene in multiple cancers
Somatic hotspot mutations and structural amplifications and fusions affecting fibroblast growth factor receptor 2 (FGFR2) occur in multiple cancer types. However, clinical responses to FGFR inhibitors (FGFRi) have remained variable, emphasizing a need to better understand which FGFR2 alterations are...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-06 | PXD031711 | Pride
Cancer Fgfr2 Imac Mouse model Ptyrip Label-free Phosphoproteomics 
GenomicsSignaling suppressive determinants of the FGFR2 C-terminus
Signaling suppressive determinants of the FGFR2 C-terminus
PRJEB60417 | ENA
ProteomicsThe C-terminal phenylalanine–serine KDBS motif prevents constitutive activation of the FGFR2 proto-oncogene
Dysregulated FGF/FGFR signaling leads to a variety of pathologies. These include cancer as well as congenital syndromes that affect skeleton development, impair the response to injury, and/or result in metabolic disorders. In human cancers, the FGFR genes can be affected by hotspot missense mutation...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-17 | PXD041797 | Pride
Fgfr2 signaling Immunoprecipitation Shotgun Lc-ms/ms 
TranscriptomicsFGFR2 Signaling Underlies p63 Oncogenic Function in Squamous Cell Carcinoma
This study was designed to examine the requirement for the p63 transcription factor in Squamous Cell Carcinoma (SCC) tumor maintenance in an in vivo murine system. A tamoxifen-inducible Keratin 14-driven Cre recombinase transgene was used to conditionally excise p63 in advanced murine SCC tumors. ...
ORGANISM(S): Mus musculus 
2013-08-06 | E-GEOD-45929 | biostudies-arrayexpress
GenomicsFGFR2 Directs Inhibition of WNT Signaling to Regulate Anterior Fontanelle Closure during Skull Development
FGFR2 Directs Inhibition of WNT Signaling to Regulate Anterior Fontanelle Closure during Skull Development
PRJNA1208663 | ENA
GenomicsThe developing lens transcriptome depends upon a counterbalance of Fgfr2- and Pten-regulated downstream signaling and transcription factor targets
The developing lens transcriptome depends upon a counterbalance of Fgfr2- and Pten-regulated downstream signaling and transcription factor targets
PRJNA549507 | ENA
GenomicsFGFR2 fusion protein-driven mouse models of intrahepatic cholangiocarcinoma unveil a necessary role for Erk signaling
FGFR2 fusion protein-driven mouse models of intrahepatic cholangiocarcinoma unveil a necessary role for Erk signaling
PRJNA632601 | ENA
TranscriptomicsInhibiting tankyrases sensitizes KRAS mutant cancer cells to MEK inhibitors by FGFR2 feedback signaling
Tankyrases (TNKS) play roles in Wnt signaling, telomere homeostasis and mitosis, offering attractive targets for anti-cancer treatment. Using unbiased combination screening in a large panel of cancer cell lines, we have identified a strong synergy between TNKS and MEK inhibitors in KRAS mutant cance...
ORGANISM(S): Homo sapiens 
2014-03-06 | E-GEOD-55624 | biostudies-arrayexpress
GenomicsIdentification of potent biparatopic antibodies targeting FGFR2 fusion driven cholangiocarcinoma
Identification of potent biparatopic antibodies targeting FGFR2 fusion driven cholangiocarcinoma
PRJNA1186575 | ENA
UnknownFGFR2 residence in primary cilia is necessary for epithelial cell signaling.
Not available
S-EPMC12010920 | biostudies-literature
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