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MetabolomicsDual Effects of Fasting on Gut Microbiota and Metabolism: Protective Adaptation versus Barrier Dysfunction Risks
Fasting is increasingly recognized as a metabolic intervention that reshapes gut microbiota and host metabolism, but its duration-dependent effects on intestinal epithelial integrity remain incompletely understood. In this study, we compared ad libitum feeding, 12 h fasting, and 24 h fasting in male...
2026-07-20 | MTBLS15098 | MetaboLights
MetabolomicsEarly-Life Intervention with Lactobacillus reuteri Enhances Intestinal2 Barrier Function and Resilience in Suckling Piglets via Modulation of3 Gut Microbiota and Metabolites
Early-life nutritional interventions are pivotal for promoting piglet growth and health, particularly in reducing weaning-associated disorders. This study investigated the effects of early-life Lactobacillus reuteri (L.reuteri) supplementation on growth performance, immune function, intestinal morph...
2026-03-27 | MTBLS14164 | MetaboLights
TranscriptomicsLack of microRNA-101 causes E-cadherin expression and function deregulation through EZH2 up-regulation in gastric cancer
Background & Aims: E-cadherin expression disruption is commonly observed in epithelial cancers and metastasis. Such event is also recognized as a crucial step in gastric cancer (GC) initiation and progression. As aberrant expression of microRNAs often perturb the normal expression and function of pi...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-33743 | biostudies-arrayexpress
TranscriptomicsExpression data from HT29 intestinal epithelial cell line
The study recapitulates, through in vitro micropatterned co-cultures, interactions between HIV-infected T-lymphocytes and intestinal epithelial cells in order to investigate the mechanisms underlying the disruption of normal epithelial cell and barrier function during HIV infection. The co-culture m...
ORGANISM(S): Homo sapiens 
2014-03-22 | E-GEOD-56090 | biostudies-arrayexpress
MetabolomicsWLJP-025p Promote Colonic Epithelial Repair in Ulcerative Colitis through Fatty Acid Oxidation by Regulating Microbial-involvemented SPD Production

BACKGROUND & AIMS: Ulcerative colitis (UC) poses a serious threat to human health. WLJP-025p, a polysaccharide component of Lonicera japonica thunb. has been confirmed to have anti-inflammatory and immunomodulatory effects. This study intends to explore the effects and mechanism of WLJP-025p ...

2026-05-16 | MTBLS12400 | MetaboLights
ProteomicsPhysical, chemical, and structural properties of human gastric organoid-derived mucus
We explored the potential of human gastric organoids as models for mucus production. Immunofluorescence staining confirmed that the organoids produced mucus containing MUC5AC and MUC6. The luminal mucus had viscoelastic properties similar to those of native human gastric mucus, as determined by part...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2025-12-30 | PXD072060 | Pride
Gastric mucus layer  organoids  air-liquid interface  gastric epithelial barrier  microrheology  organoid lumen 
TranscriptomicsmicroRNA-146b improves intestinal injury in mouse colitis by activating NF-kB and improving epithelial barrier function
Aim: The precise role of microRNAs in inflammatory disease has been less clear. The present study investigated the effect of microRNA (miR-146b) on improving intestinal inflammation. Methods: The microRNA profile in IL-10-deficient mice was examined using microRNA arrays and miR-146b was selected f...
ORGANISM(S): Mus musculus 
2012-09-10 | E-GEOD-40708 | biostudies-arrayexpress
TranscriptomicsRegulation of gene expression in IECs by HDAC3
The development and severity of inflammatory bowel diseases (IBD) and other chronic inflammatory conditions can be influenced by host genetic and environmental factors, including signals derived from commensal bacteria. However, the mechanisms that integrate these diverse cues remain undefined. Her...
ORGANISM(S): Mus musculus 
2013-11-12 | E-GEOD-50188 | biostudies-arrayexpress
TranscriptomicsEsophageal epithelium of 12 weeks old mice (WT, Nrf2-/-) on C57BL background with or without gastroesophageal reflux for 4 weeks.
Transcriptional profiling of adult esophageal epithelium comparing wild-type mice with Nrf2-/- mice with or without gastroesophageal reflux for 4 weeks. Goal was to determine the role of Nrf2 on the barrier function of mouse esophageal epithelium. Two-class comparisons. Wild-type/without reflux vs. ...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-39629 | biostudies-arrayexpress
UnknownPharmacological targeting of gastric mucosal barrier with traditional Chinese medications for repairing gastric mucosal injury.
Not available
S-EPMC10285076 | biostudies-literature
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