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ProteomicsBioID proximity proteomics of wild-type and ΔPDZ DVL2 in HEK293 Flp-In T-REx cells
This dataset supports a study investigating how the PDZ domain of Dishevelled-2 (DVL2) specifies β-catenin-independent Wnt signalling outputs. BioID proximity labelling was performed in HEK293 Flp-In T-REx cells stably expressing BirA*-tagged wild-type DVL2 or a matched DVL2 mutant lacking the PDZ d...
ORGANISM(S): Homo sapiens (Human) 
2026-09-12 | PXD079793 | Pride
Bioid  proximity labelling  proximity proteomics  dvl2  dishevelled  pdz domain  daple  girdin  girdin-l  wnt signalling  wnt5a  primary cilia  basal body  pdz-pbm interaction  lc-ms/ms  bottom-up proteomics  data-dependent acquisition  hek293 flp-in t-rex 
ProteomicsEvolution of Modularity, Interactome and Functions of GIV/Girdin (CCDC88A) from Invertebrates to Vertebrates
PDZ domains are one of the most abundant protein domains in eukaryotes and frequently found on junction-localized scaffold proteins. Various signaling molecules bind to PDZ proteins via PDZ-binding motifs (PBM) and finetune cellular signaling. Here we describe the presence of a PBM on GIV/Girdin (CC...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022601 | Pride
Lc-msms Cancer Human 
TranscriptomicsINTER_specific hybs: A Burst of Segmental Duplications in the African Great Ape Ancestor
Wilson and King were among the first to recognize that the extent of phenotypic change between humans and great apes was dissonant with the rate of molecular change. Proteins are virtually identical; cytogenetically there are few rearrangements that distinguish ape-human chromosomes; rates of single...
ORGANISM(S): Pongo abelii 
2010-05-22 | E-GEOD-13884 | biostudies-arrayexpress
TranscriptomicsINTRA_specific hybs: A Burst of Segmental Duplications in the African Great Ape Ancestor
Wilson and King were among the first to recognize that the extent of phenotypic change between humans and great apes was dissonant with the rate of molecular change. Proteins are virtually identical; cytogenetically there are few rearrangements that distinguish ape-human chromosomes; rates of single...
ORGANISM(S): Pan troglodytes 
2010-05-22 | E-GEOD-13885 | biostudies-arrayexpress
TranscriptomicsLineage-specific gene duplication and loss in human and great ape evolution
Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions ...
ORGANISM(S): Homo sapiens 
2006-01-05 | E-GEOD-3980 | biostudies-arrayexpress
TranscriptomicsA Burst of Segmental Duplications in the African Great Ape Ancestor
This SuperSeries is composed of the following subset Series: GSE13884: INTER_specific hybs: A Burst of Segmental Duplications in the African Great Ape Ancestor GSE13885: INTRA_specific hybs: A Burst of Segmental Duplications in the African Great Ape Ancestor Refer to individual Series
ORGANISM(S): Macaca mulatta 
2009-03-05 | E-GEOD-13934 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human, bonobo and gorilla fibroblast cell cultures
Data files from Genome Research paper 'Comparative analysis of gene expression patterns in human and African great ape cultured fibroblasts'
ORGANISM(S): Homo sapiens 
2007-07-19 | E-GEOD-426 | biostudies-arrayexpress
UnknownPrognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers.
Not available
S-EPMC5067257 | biostudies-literature
TranscriptomicsComparative genomic hybridization of 5 hominid species, including humans
Given that gene duplication is a major driving force of evolutionary change and the key mechanism underlying the emergence of new genes and biological processes, this study sought to use a novel genome-wide approach to identify genes that have undergone lineage-specific duplications or contractions ...
ORGANISM(S): Homo sapiens 
2013-01-30 | E-SMDB-2855 | biostudies-arrayexpress
UnknownA long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding.
Not available
S-EPMC8042451 | biostudies-literature
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