glucocorticoid signaling

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Organisms

Mus musculus (136)
Homo sapiens (125)
Rattus norvegicus (18)
Danio rerio (7)
Ovis aries (4)
Arabidopsis thaliana (3)
Macaca mulatta (2)
Bos taurus (2)
Coregonus maraena (1)
Oncorhynchus gorbuscha (1)
Suricata suricatta (1)
Tachycineta bicolor (1)
Oryctolagus cuniculus (1)
Oncorhynchus mykiss (1)
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Magallana gigas (1)

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Technology Type

Mass Spectrometry (33)
Shotgun proteomics (13)
Affinity purification coupled with mass spectrometry proteomics (10)
Bottom-up proteomics (10)
Mass spectrometry (3)
Mass spectrometry assay (3)
Data-dependent acquisition (2)
Data-independent acquisition (2)
Gel-based experiment (2)
SRM/MRM (1)
SWATH MS (1)

Instrument Platform

Illumina NovaSeq 6000 (5)
GenePix 4000A [Axon Instruments] (2)
Illumina HiSeq 2000 (2)
Illumina HiSeq 4000 (2)
LTQ (2)
LTQ Orbitrap Elite (2)
LTQ XL (2)
Q Exactive HF (2)
Liquid Chromatography MS - positive - hilic (2)
Liquid Chromatography MS - positive - reverse phase (2)
Illumina NOVAseq 6000 (1)
Performed by Novogene; Illumina library preparation instrumentation (provider standard) (1)
Chromatin IP kit (1)
Immunomagnetic separation system (e.g., Miltenyi MACS separator), Tissue culture facilities (biosafety cabinet, CO₂ incubator) , Bench centrifuge (1)
Novogene automated library prep system (1)
Qiagen RNA extraction kit (1)
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NextSeq 500 (1)
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Q Exactive (1)
TimsTOF HT (1)
Liquid Chromatography MS - (1)
Liquid Chromatography MS - alternating - reverse-phase (1)
Liquid Chromatography MS - negative - hilic (1)
Liquid Chromatography MS - negative - reverse phase (1)
Tandem Gas Chromatography MS - positive (1)

Publication Date

2026 (68)
2014 (49)
2013 (44)
2023 (37)
2008 (36)
2015 (35)
2011 (35)
2024 (35)
2025 (34)
2022 (34)
2021 (33)
2010 (30)
2016 (25)
2012 (25)
2009 (23)
2019 (21)
2020 (21)
2007 (15)
2017 (13)
2018 (10)
2006 (3)
2003 (2)
2004 (1)

CHEBI ID

CHEBI:133617 (1)
CHEBI:134073 (1)
CHEBI:137889 (1)
CHEBI:140773 (1)
CHEBI:141030 (1)
CHEBI:149661 (1)
CHEBI:15428 (1)
CHEBI:15603 (1)
CHEBI:15699 (1)
CHEBI:15756 (1)
CHEBI:15843 (1)
CHEBI:15971 (1)
CHEBI:16015 (1)
CHEBI:16196 (1)
CHEBI:16310 (1)
CHEBI:16347 (1)
CHEBI:16467 (1)
CHEBI:16643 (1)
CHEBI:167278 (1)
CHEBI:16737 (1)
CHEBI:16828 (1)
CHEBI:16919 (1)
CHEBI:16977 (1)
CHEBI:170213 (1)
CHEBI:170346 (1)
CHEBI:170412 (1)
CHEBI:17053 (1)
CHEBI:170598 (1)
CHEBI:170619 (1)
CHEBI:170661 (1)

Metabolite Name

Chenodeoxycholic acid (2)
LysoPE(18:2(9Z,12Z)/0:0) (2)
Ursodeoxycholic acid (2)
(+)-(E,E)-3-Hydroxy-7-phenyl-4,6-heptadienic acid (1)
(+)-Neomethynolide (1)
(+)-Prosopinine (1)
(+)-Rauflorine (1)
(+/-)-lefetamine (1)
(-)-Epigallocatechin (1)
(-)-Epothilone E (1)
(-)-Hydroxydihydrobovolide (1)
(-)-Isobebeerine (1)
(-)-trans-C75 (1)
(10betaH,11xi)-11-Hydroxy-13-nor-6-eremophilen-8-one (1)
(13S,14S)-epoxymaresin (1)
(1R,4R)-p-Mentha-2,8-dien-1-ol (1)
(1S,2R,5S,6R)-5,6-dihydroxy-2-methylcyclohex-3-enecarboxylic acid|massarigenin E (1)
(1S,4S)-4-Hydroxy-3-oxocyclohexane-1-carboxylate (1)
(1xi,3xi)-1,2,3,4-Tetrahydro-1-methyl-beta-carboline-3-carboxylic acid (1)
(2E,4E)-2,4-Hexadienoic acid (1)
(2S)-2r,8c,17t-triisobutyl-5c,11c,14t-triisopropyl-7-methyl-1,4,10-trioxa-7,13,16-triaza-cyclooctadecane-3,6,9,12,15,18-hexaone|cyclo-(L-2-hydroxy-3-methyl-butyryl->N-methyl-L-leucyl->L-2-hydroxy-3-methyl-butyryl->D-valyl->D-leucyl->L-2-hydroxy-4-methyl-pentanoyl)|Pimaydolid|pimaydolide (1)
(2S)-methylbutanenitrile (1)
(2S,3R)-2,3-Dihydroxy-5-oxohexanedioate (1)
(2S,3R,4R,5S,6S)-2-(Hydroxymethyl)-6-phenylmethoxyoxane-3,4,5-triol (1)
(2S,3S,4R,5R)-2,5-epoxy-3,4-dimethyl-8,9-methylenedioxy-10-methoxy-6,11-benzocycloheptan-1-one|gymnothedelignan A (1)
(3E,5Z)-1,3,5-Heptatriene (1)
(5R,6E)-5-Hydroxy-1,7-Diphenyl-6-Hepten-3-One (1)
(6S,8S)-5,6,7,8-tetrahydro-1,3,6-trihydroxy-6-acetyl-8-methylnaphthalene-4-carboxylic acid|ficuselastic acid (1)
(8R,9R,10S,13S,14S)-13-Methyl-1,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene (1)
(E)-10a-(2-(allyloxy)styryl)-10,10-dimethyl-3,4,10,10a-tetrahydropyrimido[1,2-a]indol-2-ol (1)

IsPrivate

False (1)

First Public Date

2026 (65)
2014 (54)
2024 (39)
2023 (32)
2022 (28)
2021 (27)
2025 (24)
2020 (19)
2019 (17)
2017 (15)
2015 (9)
2018 (6)
2016 (5)
2013 (5)

Modelling Approach

Ordinary differential equation model (1)

Study type

Transcription profiling by array (205)
ChIP-seq (24)
RNA-seq of coding RNA (21)
Unknown experiment type (4)
Methylation profiling by array (3)
Transcription profiling by SAGE (2)
ChIP-chip by tiling array (2)
RNA-seq of coding RNA from single cells (2)
RNA-seq of non coding RNA (2)
Differential (1)
RNAi profiling by array (1)
Transcription profiling by RT-PCR (1)
RNA-seq of total RNA (1)

Release Date

2021 (128)
2022 (127)
2023 (119)
2025 (106)
2019 (99)
2020 (98)
2018 (92)
2014 (83)
2013 (80)
2016 (77)
2015 (76)
2024 (75)
2017 (73)
2012 (67)
2011 (60)
2010 (52)
2008 (44)
2009 (42)
2026 (22)
2007 (22)
2006 (8)
2005 (5)
2004 (3)
2003 (3)
2002 (2)

Lab affiliation

Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Munich, Germany (3)
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (2)
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto (2)
Novo Nordisk Foundation Center for Protein Research, University of Copenhagen (2)
The Gene Lay Institute of Immunology and Inflammation Harvard Medical School and Brigham and Women's Hospital (2)
Biomarker Assay Development 1 Novo Nordisk Park 1 Måløv, Denmark (1)
Claudia Fecher-Trost Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University, Buildings 46, D-66421 Homburg, Germany (1)
Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg im Breisgau, Germany (1)
Department of Health Sciences and Technology (D-HEST) Institute Neurosciences, ETH Zurich (1)
Department of Internal Medicine, Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, United States (1)
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20007, USA (1)
Department of Pathology and Cancer Center, Stony Brook University, Stony Brook, NY 11794 (1)
Department of Urology, Department of Biochemistry and Molecular Biology, Cancer Research Institute, SUNY Upstate Medical University, 750 E. Adams St., Syracuse, NY 13210, USA (1)
ETH Zurich – Institute for Neuroscience, Department of Health Sciences and Technology, Lab of Epigenetics and Neuroendocrinology, Neuroscience Center Zürich (1)
Fujian Medical University (1)
III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (1)
Institute for Diabetes and Endocrinology (IDE) Helmholtz Zentrum München Ingolstaedter Landstr. 1 85764 Neuherberg, Germany (1)
Keck MS & Proteomics Resource Yale School of Medicine (1)
Ludwig-Maximilians-Universität München, Department of Physiological Genomics - BioMedical Center BMC Großhaderner Str. 9 D-82152 Planegg-Martinsried (1)
Lymphoid Malignancies Branch Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda, Maryland (1)
Pablo Menéndez, ICREA Research Professor Stem cell biology, developmental leukemia & immunotherapy Lab Josep Carreras Leukaemia Research Institute Associate Professor - School of Medicine - University of Barcelona Carrer casanova 143. Barcelona 08036. Spain Tel. (+34) 932414287 (1)
Prof. Dr. Karolien De Bosscher - Staff Scientist VIB-UGent Center for Medical Biotechnology Albert Baertsoenkaai 3 - 9000 Gent - Belgium (1)
Professor, Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, 99202, United States (1)
Proteomics Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Re-search, Utrecht Institute for Pharmaceutical Sciences, Utrecht University and Netherlands Proteomics Centre, Utrecht, The Netherlands (1)
Proteomics facility, Central Science Laboratory, University of Tasmania (1)
University of Copenhagen (1)
University of Victoria (1)

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Hes1 and Liver Glucocorticoid Signaling

To investigate the role of HES1 during glucocorticoid signaling in the liver, we employed whole-genome microarray expressions in liver mRNA extracted from control and Hes1-liver knockout male mice (HESKOL) that had been adrenalectomized to remove endogenous glucocorticoids. RNA isolated from the liv...

ORGANISM(S): Mus musculus

2014-01-08 | E-GEOD-52106 | biostudies-arrayexpress

Hes1 and Glucocorticoid Signaling in Bone Sarcoma Cells

To investigate the role of HES1 during glucocorticoid signaling in bone sarcoma cells (U2OS-GR cells) , we employed whole-genome microarray expressions in mRNA extracted from control U2OS-GR and Hes1-overexpressed U2OS-GR cells. RNA isolated from control U2OS-GR and Hes1-overexpressed U2OS-GR cells...

ORGANISM(S): Homo sapiens

2014-01-21 | E-GEOD-52727 | biostudies-arrayexpress

Potentiation of glucocorticoid signaling by chloroquine via inhibition of lysosomes

Anti-malaria drug chloroquine has been used as an anti-inflammatory agent for treating systemic lupus erythematosus and rheumatoid arthritis, without clear mechanism of action. Here we report that chloroquine potently inhibits the expression of proinflammatory cytokines through transrepression of g...

ORGANISM(S): Homo sapiens

2012-01-18 | E-GEOD-24579 | biostudies-arrayexpress

Glucocorticoid Receptor and Androgen Receptor DNA binding in LREX'

LREX' are a LnCAP/AR subline with natural expresison of the glucocorticoid receptor. We used the model to compare the AR and GR cistromes in prostate tissue. We determined the GR cistrone in the presence of Dex (100nM) treatment and the AR cistrome in the presene of DHT (1nM) treatment.

ORGANISM(S): Homo sapiens

2013-12-27 | E-GEOD-51497 | biostudies-arrayexpress

Transcription profiling of human Acute Lymphoblastic Leukemia CEM_C1 cells treated with rapamycin identifies rapamycin as a glucocorticoid resistance reversal agent

Drug resistance remains a major obstacle to successful cancer treatment. Here we use a novel approach to identify rapamycin as a glucocorticoid resistance reversal agent. A database of drug-associated gene expression profiles was screened for molecules whose profile overlapped with a gene expression...

ORGANISM(S): Homo sapiens

2008-11-06 | E-GEOD-5824 | biostudies-arrayexpress

Gut microbiota-derived deoxycholic acid promotes pancreatic regeneration following acute pancreatitis via Reg3a signaling pathway

Recovery from acute pancreatitis (AP) involves complex biological processes, and the mechanisms governing pancreatic repair remain unclear. In a clinical cohort during the recovery phase of AP, impaired pancreatic recovery was associated with intestinal dysbiosis, depletion of the microbial bile ...

2026-03-08 | MTBLS14000 | MetaboLights

Role of Serine 134 phosphorylation of the glucocorticoid receptor (GR) in glucocorticoid signaling

In response to environmental stressors and a variety of inflammatory cytokines, p38 MAPKs become directly activated. Here we report the human glucocorticoid receptor (GR) Serine 134 as a novel target for p38 MAPK. Unlike most other phosphorylation events that occur on the GR, phosphorylation of Ser1...

ORGANISM(S): Homo sapiens

2011-10-04 | E-GEOD-28912 | biostudies-arrayexpress

Glucocorticoid receptor profiling in U2OS cells expressing GRalpha or GRgamma isoform

To determine whether insertion of a single amino acid had an effect on Glucocorticoid receptor (GR) occupancy, we performed ChIP-seq of GRalpha and GRgamma in the same U2OS osteosarcoma cell lines, upon glucocorticoid treatment. These assays are also part of submission E-MTAB-2955

ORGANISM(S): Homo sapiens

2014-08-08 | E-MTAB-2731 | biostudies-arrayexpress

S1PR2 Signaling in Chronic Glucocorticoid Exposure-Induced Metabolic Disorders

PRJNA633023 | ENA

Transcription profiling of human T-ALL samples to investigate synergistic interaction of gamma-secretase inhibitor therapy and glucocorticoids

Glucocorticoids are an essential component of the treatment of lymphoid malignancies and resistance to glucocorticoid therapy constitutes a prominent clinical problem in relapsed and refractory lymphoblastic leukemias. Constitutively active NOTCH signaling is involved in the pathogenesis of over 50%...

ORGANISM(S): Homo sapiens

2009-01-13 | E-GEOD-7067 | biostudies-arrayexpress

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