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ProteomicsC-terminal-dependent control of EAAT2 signaling, corticostriatal synaptic glutamate clearance and spontaneous motor activity in mice with hypokinesia
Deficiency of the astrocytic excitatory amino acid transporter type 2 (EAAT2) and, consequently, inefficient glutamate clearance at corticostriatal synapses may contribute to the depression of self-initiated movements in HuntingtonÕs disease (HD). Here we report that the removal of the last 68 amino...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-26 | PXD029194 | Pride
Huntington's disease  eaat2 interaction proteomics  hypokinesia  corticostriatal synaptic transmission  glutamate clearance  synaptic targeting of eaat2 
UnknownDifferential impact of manganese on glutamate clearance, electroencephalography, and sleep in Alzheimer's disease.
Not available
S-EPMC12549221 | biostudies-literature
UnknownA CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance.
Not available
S-EPMC4682051 | biostudies-literature
UnknownDefective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2.
Not available
S-EPMC4967947 | biostudies-literature
UnknownReal-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models.
Not available
S-EPMC4829692 | biostudies-literature
UnknownIn vivo glutamate clearance defects in a mouse model of Lafora disease.
Not available
S-EPMC6708466 | biostudies-literature
UnknownMalignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci.
Not available
S-EPMC8943616 | biostudies-literature
TranscriptomicsAlbumin, TGF-Beta1 and Blood-Brain Barrier opening induce cortical epileptogenesis.
Insults to the cerebral cortex, such as trauma, ischemia or infections, may result in the development of epilepsy, one of the most common neurological disorders. Previous studies have suggested that perturbations in neurovascular integrity and breakdown of the blood-brain barrier (BBB) lead to neuro...
ORGANISM(S): Rattus norvegicus 
2009-07-15 | E-GEOD-12304 | biostudies-arrayexpress
UnknownCharacterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model.
Not available
S-EPMC5718321 | biostudies-literature
UnknownUncoupling the Excitatory Amino Acid Transporter 2 From Its C-Terminal Interactome Restores Synaptic Glutamate Clearance at Corticostriatal Synapses and Alleviates Mutant Huntingtin-Induced Hypokinesia.
Not available
S-EPMC8841566 | biostudies-literature
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