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MetabolomicsTargeting GSTZ1 sensitizes KRASG12C-mutant lung cancer cells by overcoming glutathione and glycolysis pathway rewiring

KRAS mutations are prevalent in lung cancer, but KRAS G12C inhibitors exhibit limited efficacy, partly due to metabolic adaptations, such as enhanced glutathione metabolism and increased glycolysis. Glutathione S-Transferase Zeta 1 (GSTZ1) is a metabolic enzyme that regulates cell metabolism. How...

2026-05-15 | MTBLS12791 | MetaboLights
Genomicsglutathione s-transferase
production of glutathione s-transferase from Lactobacillus plantarum Ku720558
PRJEB33504 | ENA
TranscriptomicsInteractions between H2O2 and glutathione in gene expression
rs08-03_glutathion - glutathion - How does glutathione content or reduction state affect H2O2-induced changes in the transcriptome? - Three single Arabidopsis mutants were used: cat2, knockout for catalase2 and so enriched in H2O2; cad2, defective in glutathione content; cytGR, knockout for cytosoli...
ORGANISM(S): Arabidopsis thaliana 
2010-07-22 | E-GEOD-21424 | biostudies-arrayexpress
ProteomicsGlutathione S-transferase induction after exposure to benzo[a]pyrene
Benzo[a]pyrene induction of glutathione S-transferases, an activity-based protein profiling investigation
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD010610 | Pride
Gsh Mouse Polycyclic aromatic hydrocarbons Gst Glutathione Pah Benzo[a]pyrene B[a]p 
TranscriptomicsGSTM3 single nucleotide polymorphism (rs7483) associated with peripheral BMC expression in Alzheimer disease
Comparisons between the sample groups (normal elderly control (NEC) and Alzheimer disease (AD)) allowed the identification of genes with disease expression patterns associated with the glutathione S-transferase M3 single nucleotide polymorphism rs7483. Keywords: biological repeat Peripheral blood mo...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-4227 | biostudies-arrayexpress
TranscriptomicsVariation of gene expression associated with colonisation of an anthropized environment: comparison between African and European populations of Drosophila simulans
The comparison of transcriptome profiles among populations is a powerful tool for investigating the role of gene expression change in adaptation to new environments. In this study, we use massively parallel sequencing of 39 cDNAs obtained from large samples of adult males, to compare a population of...
ORGANISM(S): Drosophila simulans 
2013-11-22 | E-GEOD-49127 | biostudies-arrayexpress
ProteomicsActivity-Based Probes for Isoenzyme- and Site-Specific Functional Characterization of Glutathione S-transferases
Characterization of Glutathione S-transferase activity associated with phase II drug metabolism.
ORGANISM(S): Mus musculus (Mouse) 
2018-10-22 | PXD006920 | Pride
Gsh Mouse Gst Glutathione 
GenomicsProtein/DNA in vitro Binding seq (PB-seq) for Drosophila HSF and genomic Drosophila DNA
DNA sequence and local chromatin landscape act jointly to determine transcription factor (TF) binding intensity profiles. To disentangle these influences, we developed an experimental approach, called protein/DNA binding and high-throughput sequencing (PB-seq), that allows the binding energy landsca...
ORGANISM(S): Drosophila melanogaster 
2012-02-06 | E-GEOD-32570 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung from mouse exposed to carbonyl chloride (phosgene) for different lengths of time to investigate the molecular mechanism of phosgene-induced lung injury
Carbonyl chloride (phosgene) is a toxic industrial compound (TIC) widely used in industry for the production of synthetic products, such as polyfoam rubber, plastics, and dyes. Exposure to phosgene results in a latent (1-24 hr), potentially life-threatening pulmonary edema and irreversible acute lu...
ORGANISM(S): Mus musculus 
2007-06-25 | E-GEOD-2565 | biostudies-arrayexpress
UnknownGlutathione Transferase (GST)-Activated Prodrugs.
Not available
S-EPMC3834953 | biostudies-literature
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