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MetabolomicsCorpora amylacea profiling reveals disease stage and brain region-specific alterations in glycogen metabolism in Alzheimer’s disease patient brains (MS (MTBLS))

Increasing evidence indicates that shifts in brain polysaccharide metabolism can influence the progression of multiple neurodegenerative diseases. Here we perform MALDI-MSI analysis of glycogen at different chain lengths in patients at different stages of Alzheimer's Disease. We look at frontal c...

2026-06-12 | MTBLS14754 | MetaboLights
MetabolomicsGlycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans
Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp), which operates an evolutionarily conserved glycerol shunt that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol, coun...
2024-02-07 | MTBLS6847 | MetaboLights
TranscriptomicsThe glycogen scaffolding protein PTG coordinately regulates glycogen and lipid storage
Glycogen and lipid are major storage forms of energy that are tightly regulated by hormones and metabolic signals. Here, we evaluate the role of the glycogenic scaffolding protein PTG/R5 in energy homeostasis. We demonstrate that feeding mice a high-fat diet (HFD) increases hepatic glycogen, corresp...
ORGANISM(S): Mus musculus 
2014-06-13 | E-GEOD-45319 | biostudies-arrayexpress
ProteomicsGlycogen synthesis jump-starts photosynthesis through the G6P shunt in cyanobacteria
Proteomics analysis on Synechococcus elongatus PCC 7942 wild type and glycogen mutant cells. Cells growing under the light and dark incubated cells were analyzed for their protein abundance profile.
ORGANISM(S): Synechococcus Elongatus Pcc 7942 (ncbitaxon:1140) 
2019-03-14 | MSV000083575 | MassIVE
TranscriptomicsAltered glycogen metabolism causes hepatomegaly following an Atg7 deletion
Autophagy is a lysosomal degradation process involved in the turnover of organelles or other cell constituents, in providing sources for energy production under starving conditions, and in cell metabolism. A key protein in the macroautophagic machinery is the autophagy related protein (Atg) 7. Const...
ORGANISM(S): Mus musculus 
2016-07-12 | E-MTAB-4389 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of muscles from mice with genetically modified muscle glycogen content to study the impact of glycogen content on gene expression.
Anterior tibialis removed from 3-month old muscle glycogen synthase WT or knockout mouse. RNA was extracted using GibcoBRL TRIzol Reagent and a Quiagen RNeasy kit. Targets were produced using standard Affymetrix procedures from about 5ug of total RNA. GSM40057-GSM40063 AND GSM40956. Liver removed fr...
ORGANISM(S): Mus musculus 
2007-09-25 | E-GEOD-2198 | biostudies-arrayexpress
ModelsKoenig2012 - Hepatic Glucose Metabolism
Quantifying the Contribution of the Liver to Glucose Homeostasis: A Detailed Kinetic Model of Human Hepatic Glucose Metabolism Kinetic Model of Human Hepatic Glucose Metabolism Authors Matthias Koenig, Sasc...
2005-01-01 | MODEL1204270001 | BioModels
ModelsKoenig2012 - Hepatic Glucose Metabolism
Kinetic Modeling of Human Hepatic Glucose Metabolism in Type 2 Diabetes Mellitus Predicts Higher Risk of Hypoglycemic Events in Rigorous Insulin Therapy* Kinetic Model of Human Hepatic Glucose Metabolism in T2DM Authors ...
2005-01-01 | MODEL1209260000 | BioModels
GenomicsGlycogen Metabolism Drives Sensory Activation of Pomc Neurons
Glycogen Metabolism Drives Sensory Activation of Pomc Neurons
PRJNA930442 | ENA
GenomicsHydrogen metabolism influences glycogen production in a verrucomicrobial methanotroph
Hydrogen metabolism influences glycogen production in a verrucomicrobial methanotroph
PRJNA548264 | ENA
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