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MetabolomicsLipidomic analysis of human brain from frontotemporal dementia cases of with GRN and C9orf72 mutations
Not available
ORGANISM(S): Homo sapiens 
ST002452 | MetabolomicsWorkbench
ProteomicsDistinguishing post-translational modifications in dominantly inherited FTD: FTLD-TDP Type A (GRN) versus Type B (C9orf72)
Frontotemporal dementias are neuropathologically characterized by frontotemporal lobar degeneration (FTLD). Intraneuronal inclusions of transactive response DNA-binding protein 43 kDa (TDP-43) are the defining pathologic hallmark of approximately half of the FTLD cases, being referred to as FTLD-TDP...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-12 | MSV000089242 | MassIVE
GenomicsPanicum virgatum strain:GRN | cultivar:GRN
Panicum virgatum GRN Resequencing genome sequencing
PRJNA334735 | ENA
TranscriptomicsFunctional Genomic Analyses Identify Pathways Dysregulated by Progranulin Deficiency Implicating Wnt Signaling
Progranulin (GRN) mutations cause frontotemporal dementia (FTD), but GRN's function in the CNS remains largely unknown. To identify the pathways downstream of GRN, we used weighted genome co-expression network analysis (WGCNA) to develop a systems-level view of transcriptional alterations in a human...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-31772 | biostudies-arrayexpress
ProteomicsDistinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia
INTRODUCTION: Frontotemporal dementia (FTD) is characterized by progressive atrophy of frontal and/or temporal cortices and considerable clinical, pathological, and genetic heterogeneity. METHODS: Frontal and temporal cortex tissues from FTD-GRN (n=9), FTD-MAPT (n=13), and non-demented controls (n=1...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031419 | Pride
Frontotemporal dementia  grn  mapt  human brain proteomics  cell type enrichment 
GenomicsEffect of constitutive Grn KO on BMDM transcriptome [HEX000747_BMDM]
Effect of constitutive Grn KO on BMDM transcriptome [HEX000747_BMDM]
PRJNA1136510 | ENA
ProteomicsDeficiency of the frontotemporal dementia gene GRN results in gangliosidosis
Haploinsufficiency of GRN causes frontotemporal dementia (FTD). The GRN locus produces progranulin (PGRN), which is cleaved to lysosomal granulin polypeptides. The function of lysosomal granulins and why their absence causes neurodegeneration are unclear. Here we discover that PGRN-deficient human c...
ORGANISM(S): Homo sapiens (Human) 
2022-09-18 | PXD035889 | Pride
Haploinsufficiency Lysosome Bmp Pgrn Frontotemporal dementia Gangliosides 
GenomicsA key netwrok hub gene GRN confers chemo resistance in H2081 SCLC cells.
A key netwrok hub gene GRN confers chemo resistance in H2081 SCLC cells.
PRJNA1026975 | ENA
GenomicsEffect of lysosomal acidification on Grn knockout primary microglia transcriptome [HEX000747_MG]
Effect of lysosomal acidification on Grn knockout primary microglia transcriptome [HEX000747_MG]
PRJNA1136519 | ENA
ProteomicsGENETIC SUBTYPE- AND CELL TYPE-SPECIFIC PROTEIN SIGNATURES IN FRONTOTEMPORAL DEMENTIA
Frontotemporal dementia is characterized by progressive atrophy of frontal and/or temporal cortices and an early age of onset. The disorder is highly heterogenic, comprising several genetic causes as well as a diverse phenotypic landscape of sporadic cases. Here we investigated the proteomic signatu...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD022872 | Pride
Frontotemporal dementia  c9orf72  grn  mapt  human brain proteomics 
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