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TranscriptomicsProgranulin A mediated MET signalling is essential for liver morphogenesis in zebrafish
Regulation of embryonic liver growth remains largely elusive. Progranulin has been discussed in pathological liver growth; however, the functional role of Pgrn in embryonic liver growth has never been addressed. Knockdown of GrnA, the orthologue of mammalian pgrn in zebrafish, displayed a deficien...
ORGANISM(S): Danio rerio 
2010-11-10 | E-GEOD-19211 | biostudies-arrayexpress
TranscriptomicsInduced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.
Multiple FTD patient-specific iPSC lines were generated for the first time, Human neurons of progranulin haploinsufficiency have been established. PGRN S116X neurons are more sensitive to kinase inhibitors-induced cell stress, which can be rescued by ectopic progranulin expression, revealing progran...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-40378 | biostudies-arrayexpress
ProteomicsTMT-based quantitative proteomics analysis reveals the new regulatory mechanism of PGRN in influenza virus infection
To gain insight into the potential molecular mechanisms by which PGRN regulates influenza viral replication, proteomic analyses of whole mouse lung tissue from wild-type (WT) versus (vs) PGRN knockout (KO) mice were performed to identify proteins regulated by the absence vs presence of PGRN.
ORGANISM(S): Mus Musculus 
2022-12-19 | PXD038885 |
UnknownParkin Levels Decrease in Fibroblasts With Progranulin (PGRN) Pathogenic Variants and in a Cellular Model of PGRN Deficiency.
Not available
S-EPMC8155584 | biostudies-literature
UnknownVoxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN.
Not available
S-EPMC2677544 | biostudies-literature
GenomicsComparative gene expression profiling analysis of scRNA-seq data for WT and PGRN-KO mice. [scRNA-Seq]
Comparative gene expression profiling analysis of scRNA-seq data for WT and PGRN-KO mice. [scRNA-Seq]
PRJNA1308090 | ENA
TranscriptomicsComparative gene expression profiling analysis of scRNA-seq data for WT and PGRN-KO mice. [scRNA-Seq]
We have employed a single-cell sequencing approach using 10x Genomics scRNA-seq to investigate the main cellular source of PGRN expression and the cell types affected by PGRN deficiency in APAP-ALI.
ORGANISM(S): Mus musculus 
2026-08-19 | GSE305873 | GEO
GenomicsComparative gene expression profiling analysis of RNA-seq data for WT and PGRN-KO mice.
Comparative gene expression profiling analysis of RNA-seq data for WT and PGRN-KO mice.
PRJNA1304549 | ENA
GenomicsPGRN: Pharmacogenomics of Anti-Platelet Interventions (The PAPI Study)
PGRN: Pharmacogenomics of Anti-Platelet Interventions (The PAPI Study)
PRJNA80255 | ENA
UnknownAdministration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner.
Not available
S-EPMC4615047 | biostudies-literature
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