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TranscriptomicsGene expression profiling of uterine stromal cells isolated from Hand2 floxed and Hand2 ablated mice on day 4 of pregnancy
Our previous study revealed that the basic helix-loop-helix transcription factor Hand2 is a downstream target of progesterone signaling in mouse uterine stroma at the time of implantation. Further, conditional deletion of Hand2 in mouse uterus leads to implantation failure due to impaired uterine ep...
ORGANISM(S): Mus musculus 
2011-06-03 | E-GEOD-25881 | biostudies-arrayexpress
TranscriptomicsTranscription profile of zebrafish hand2 (hanS6 allele) mutant embryos at 19hpf
Heart formation requires the fusion of bilateral cardiomyocyte populations as they move toward the embryonic midline. The bHLH transcription factor Hand2 is essential for cardiac fusion; however, the effector genes that execute this function of Hand2 are unknown. Here, we provide the first evidenc...
ORGANISM(S): Danio rerio 
2010-08-03 | E-GEOD-23381 | biostudies-arrayexpress
TranscriptomicsGene profiling of Hand2 target genes and transcriptional regulation of Hand2 expression in the postnatal myocardium
In humans, cardiac hypertrophy is the principal risk factor for the development of overt heart failure and sudden cardiac death from lethal arrhythmias. Although aberrant reactivation of fetal² gene programs is intricately linked to maladaptive hypertrophy of postnatal cardiomyocytes, loss of cardi...
ORGANISM(S): Mus musculus 
2013-11-15 | E-MTAB-1821 | biostudies-arrayexpress
TranscriptomicsExpression data from Hand2 mutant mouse embryos
Acquisition of the lower jaw (mandible) was evolutionarily important for jawed vertebrates. In humans, syndromic craniofacial malformations often accompany jaw anomalies. Hand2 is involved in coordinating the developmental network of mandibles and the oral apparatus through Hand2-downstream genes an...
ORGANISM(S): Mus musculus 
2015-12-15 | E-GEOD-75805 | biostudies-arrayexpress
ProteomicsBclaf1 Drives Heart Failure by Recruiting Srsf2 to Enhance Hand2 Pre-mRNA Splicing and Pathological Hypertrophy
Heart failure with reduced ejection fraction (HFrEF) remains a major therapeutic challenge. Bcl2-associated transcription factor 1 (Bclaf1) is implicated in RNA splicing and cardiac disease, but its role in HFrEF pathogenesis is unknown. Here, we demonstrate that Bclaf1 expression is elevated in hum...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-27 | PXD077261 | Pride
Bclaf1  hand2  hfref  rna splicing  therapeutic target 
GenomicsHAND2 regulates regional chromation modification [HAND2-knockdown_histone_ChIPseq]
HAND2 regulates regional chromation modification [HAND2-knockdown_histone_ChIPseq]
PRJNA762918 | ENA
GenomicsThe cooperation between HAND2 and MYCN on DNA binding [HAND2-overexpression_ChIPseq]
The cooperation between HAND2 and MYCN on DNA binding [HAND2-overexpression_ChIPseq]
PRJNA762920 | ENA
GenomicsMyocardial Hand2 regulates cardiac trabeculation
Myocardial Hand2 regulates cardiac trabeculation
PRJNA1398261 | ENA
TranscriptomicsHand2 delineates mesothelium progenitors and is reactivated in mesothelioma
The mesothelium forms epithelial membranes that line the bodies cavities and surround the internal organs. Mesothelia widely contribute to organ homeostasis and regeneration, and their dysregulation can result in congenital anomalies of the viscera, ventral wall defects, and mesothelioma tumors. Non...
ORGANISM(S): Danio rerio 
2022-01-14 | E-MTAB-9727 | biostudies-arrayexpress
GenomicsIdentifying hand2 downstream targets in cardiomyocyte during early cardiogenesis
Identifying hand2 downstream targets in cardiomyocyte during early cardiogenesis
PRJNA1010830 | ENA
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