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ProteomicsIdentification of human HERC5 complexes
Host proteins including HERC5 regulate LINE-1 (L1) retrotransposition. We used immunoprecipitation followed by liquid chromatography-tandem mass spectrometry to identify proteins that associate with HERC5.
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD068064 | Pride
Line-1 Proteomics Herc5 Retrotransposon Immunoprecipitation 
TranscriptomicsIdentification of novel metastases-suppressor genes involved in lung cancer brain metastases formation.
Initial screening for potential metastases suppressors down regulated by methylation was performed using lung cancer cell line models specific for site-specific metastasation. Gene expression profiling and qRT-PCR validations were conducted on tumor tissues from primary lung cancer (LC) and brain me...
ORGANISM(S): Homo sapiens 
2014-11-18 | E-GEOD-57492 | biostudies-arrayexpress
ProteomicsISGylation of the SARS-CoV-2 N protein by HERC5 impedes N oligomerization and thereby viral RNA synthesis
Interferon (IFN)-stimulated gene 15 (ISG15), a ubiquitin-like protein, is covalently conjugated to host immune proteins such as MDA5 and IRF3 in a process called ISGylation, thereby promoting type I interferon (IFN) induction to limit the replication of Severe acute respiratory syndrome coronavirus ...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2024-08-14 | PXD053712 | Pride
Sars-cov-2  n protein  isg15  isgylation  herc5  papain-like protease 
GenomicsHERC5-HSP60 ISGylation Axis Sustains Mitochondrial Homeostasis in Glioblastoma Stem Cells to Promote Tumor Progression
HERC5-HSP60 ISGylation Axis Sustains Mitochondrial Homeostasis in Glioblastoma Stem Cells to Promote Tumor Progression
PRJNA1298778 | ENA
ProteomicsHERC5 alters mitochondrial energy metabolism pathways in NSCLC
In 2020, lung cancer remains the most diagnosed entity among men and third most among women, causing approximately 1.8 million deaths worldwide with an estimated 31.5% of new cases in men and 14.6% in women, respectively (1). Moreover, metastasized non-small cell lung cancer (NSCLC) continues to be ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD045563 | Pride
Nsclc Oxphos Cancer metabolism 
ProteomicsCellular Targets and the Lysine Selectivity of the HERC5 ISG15 Ligase
ISG15 is a type I interferon-induced ubiquitin-like protein modifier that functions in innateimmune responses. The single major human ISG15 ligase is HERC5 (hHERC5), a ribosome-associated HECT E3s that broadly ISGylates proteins cotranslationally. Here, we characterized the hHERC5-dependent ISGylome...
ORGANISM(S): Homo sapiens (Human) 
2024-03-05 | PXD044834 | Pride
Innate immunity Post-translational modifications Herc5 Type i interferon Isg15 Herc6 Ubiquitin-like proteins Hect e3 
TranscriptomicsHERC5-HSP60 ISGylation Axis Sustains Mitochondrial Homeostasis in Glioblastoma Stem Cells to Promote Tumor Progression
Glioblastoma (GBM), the most aggressive primary central nervous system (CNS) malignancy, exhibits rapid progression, therapy resistance, and inevitable recurrence—hallmarks primarily driven by glioblastoma stem cells (GSCs). Within the tumor microenvironment, dynamic crosstalk between GSCs and cytok...
ORGANISM(S): Homo sapiens 
2026-03-01 | GSE304023 | GEO
TranscriptomicsSearch for specific biomarkers of IFN-beta bioactivity in patients with MS
We aimed to identify specific biomarkers of IFN-beta bioactivity in order to compare their gene expression induction by type I IFNs with the MxA, and to investigate their potential role in MS pathogenesis. Gene expression microarrays were performed in PBMC from MS patients who developed neutralizing...
ORGANISM(S): Homo sapiens 
2010-12-18 | E-GEOD-26104 | biostudies-arrayexpress
UnknownInterferon-Induced HERC5 Inhibits Ebola Virus Particle Production and Is Antagonized by Ebola Glycoprotein.
Not available
S-EPMC8472148 | biostudies-literature
UnknownHERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis.
Not available
S-EPMC11008035 | biostudies-literature
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