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MetabolomicsSerine and 1-carbon metabolism are required for HIF-mediated protection against retinopathy of prematurity
We determined which metabolic pathways are activated by hypoxia-inducible factor 1-mediated (HIF-1-mediated) protection against oxygen-induced retinopathy (OIR) in newborn mice, the experimental correlate to retinopathy of prematurity, a leading cause of infant blindness. HIF-1 coordinates the chang...
2019-07-05 | MTBLS856 | MetaboLights
MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
MetabolomicsAtractylodin targets ASAH3L to regulate galactose metabolism and thereby modulates the HIF-1 signaling pathway for the treatment of acute lung injury

Acute lung injury (ALI) is a lung disease characterized by an excessive inflammatory response and damage to lung epithelial cells. Atractylodin (ATL) is the main active component of Atractylodes lancea (Thunb.) DC., which has good anti-inflammatory activity and protects the integrity of the epith...

2024-07-23 | MTBLS9948 | MetaboLights
MetabolomicsHIF 1 alpha type 2 cells metabolomics
Not available
ORGANISM(S): Mus musculus 
ST000274 | MetabolomicsWorkbench
TranscriptomicsHIF-1 dependent gene expression upon S. aureus infection
HIF-1 is an important transcription factor for immune responses to bacterial infection. We wanted to analyze the HIF-1 dependent gene expression upon S. aureus infection and analyzed the gene expression of HepG2 nt and HepG2 HIF-1-/- cells four hours upon infection using affymetrix human gene 1.0 st...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-44943 | biostudies-arrayexpress
GenomicsGenome-wide mapping of HIF-2 binding in 786-O clear cell renal carcinoma cells
Kidney cancer accounts for more than 100,000 deaths per year world-wide. More than 80% are clear cell tumors (ccRCCs) and the majority are associated with loss of function of the von Hippel Lindau (pVHL) tumor suppressor resulting in upregulation of HIF-{alpha} subunits, and activation of HIF-depend...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-34871 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human U251 cells treated with hypoxia inducible factor HIF-1I siRNA or a polyamide targeted against the hypoxia response element (HRE) after induction of hypoxia
Transcription mediated by hypoxia inducible factor (HIF-1) contributes to tumor angiogenesis and metastasis but is also involved in the activation of cell-death pathways and normal physiological processes. Given the complexity of HIF-1 signaling it could be advantageous to target a subset of HIF-1 ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7835 | biostudies-arrayexpress
MetabolomicsHif1α-Dependent Uncoupling Of Glycolysis Suppresses Tumor Cell Proliferation
Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while promoting glycolysis. Paradoxically, it remains unknown why lower glycolysis is compromised in human clear cell renal cell carcinomas (ccRCC), in which HIF1α acts a tumor suppressor by inhibiting cell autonomous proliferatio...
2024-03-15 | MTBLS8901 | MetaboLights
ProteomicsLack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
Hypoxia Inducible Factor (HIF) prolyl hydroxylase domain (PHD) enzymes catalyse the posttranslational hydroxylation of conserved prolyl residues in the alpha-subunit of the HIF transcription factor. These modifications, which promote the degradation of HIF-alpha subunits by the pVHL E3 ligase comple...
ORGANISM(S): Homo sapiens (Human) 
2019-08-30 | PXD013112 | Pride
Human Lc-msms In vitro Phd enzyme Prolyl hydroxylation 
MetabolomicsSMAD3 and HIF-1α Orchestrate Metabolic Transition to Aerobic Glycolysis as a Critical Prerequisite for Spontaneous Reprogramming of Spermatogonial Stem Cells

Spermatogonial stem cells (SSCs) possess the capacity for spontaneous reprogramming during in vitro culture, while the underlying mechanisms remain poorly understood, especially why addition of epidermal growth factor (EGF), leukemia inhibitory factor (LIF) remarkably enhanced transition efficien...

2025-07-08 | MTBLS12698 | MetaboLights
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