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MetabolomicsACAD8 deficiency promotes pathological cardiac hypertrophy in response to pressure overload by regulating histone isobutyrylation
Branched-chain amino acids play critical roles in cardiac physiology and diseases. Genetic deficiency in the valine catabolic enzyme ACAD8 is clinically associated with isobutyryl-CoA deregulation and cardiomyopathy in humans. To explore the mechanism underlying cardiac pathological hypertrophy in A...
2026-04-15 | MTBLS14207 | MetaboLights
ModelsKoster1988_Histone_Expression
This model is described in the article: Kinetics of histone gene expression during early development of Xenopus laevis. Koster JG, Destrée OH and Westerhoff HV. J Theor Biol. 1988 Nov 21;135(2):139-67. PMID: 3267765 Abstract: ...
2005-01-01 | MODEL5954483266 | BioModels
GenomicsAF9 Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation
The recognition of modified histones by “reader” proteins constitutes a key mechanism regulating gene expression in the chromatin context. Compared with the great variety of readers for histone methylation, few protein modules that recognize histone acetylation are known. Here we show that the evolu...
ORGANISM(S): Homo sapiens 
2014-12-11 | E-GEOD-60366 | biostudies-arrayexpress
GenomicsGenome-wide analysis of histone modifications in human endometrial stromal cells [ChIP-Seq]
Dramatic changes of gene expressions are known to occur in human endometrial stromal cells (ESC) during decidualization. The changes in gene expression are associated with changes of chromatin structure, which are regulated by epigenetic mechanisms such as histone modifications. Here, we investiga...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-57007 | biostudies-arrayexpress
ProteomicsTwo distinct modes for propagation of histone PTMs across the cell cycle
Epigenetic states defined by chromatin can be maintained through mitotic cell division. However, it remains unknown how histone-based information is transmitted. Here we combine nascent chromatin capture (NCC) and triple-SILAC labelling to track histone modifications and histone variants during DNA ...
ORGANISM(S): Homo sapiens (Human) 
2015-03-30 | PXD001980 | Pride
Ncc  histone modifications  inheritance  chromatin  epigenetics 
GenomicsHistone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors [ChIP-seq]
Cell type-specific master transcription factors (MTFs) play vital roles in defining cell identity and function. However, the roles ubiquitous factors play in the specification of cell identity remain underappreciated. Here we show that all three subunits of the ubiquitous heterotrimeric CCAAT-bindin...
ORGANISM(S): Mus musculus 
2014-08-14 | E-GEOD-56839 | biostudies-arrayexpress
ProteomicsInsects evolved a monomeric histone-fold domain in the CENP-T protein family
The histone fold domain (HFD) is a conserved protein interaction module that requires stabilization through a handshake interaction with an HFD partner. All HFD proteins known to date form obligate dimers to shield the extensive hydrophobic residues along the HFD. Here, we find that the lepidopteran...
ORGANISM(S): Escherichia coli 
2025-09-17 | PXD063732 | Pride
Histones Evolution Insects Structure 
TranscriptomicsHistone H2B K111A
Total RNA from three replicate cultures of wild-type and mutant strains was isolated and the expression profiles were determined using Affymetrix arrays. Comparisons between the sample groups allow the identification of genes regulated by histone H2B K111A mutant. Comparison of genes whose mRNA leve...
ORGANISM(S): Saccharomyces cerevisiae 
2010-03-09 | E-GEOD-15203 | biostudies-arrayexpress
TranscriptomicsHistone H2B R102A
Total RNA from three replicate cultures of wild-type and mutant strains was isolated and the expression profiles were determined using Affymetrix arrays. Comparisons between the sample groups allow the identification of genes regulated by histone H2B R102A mutant. Comparison of genes whose mRNA leve...
ORGANISM(S): Saccharomyces cerevisiae 
2010-03-09 | E-GEOD-15202 | biostudies-arrayexpress
GenomicsGenome-wide maps of histone modifications in Arabidopsis thaliana
Histone acetylation and methylation regulate gene expression in eukaryotes, but their effects on the transcriptome of a multicellular organism and on the transcriptomic divergence between species are still poorly understood. Here we present the first genome-wide 1-bp resolution maps of histone acety...
ORGANISM(S): Arabidopsis thaliana 
2011-02-02 | E-GEOD-22276 | biostudies-arrayexpress
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