host-directed therapy

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Red blood cell BCL-xL is required for Plasmodium falciparum survival: insights into host-directed malaria therapies

The development of antimalarial drug resistance is an ongoing problem threatening progress towards malaria elimination, and antimalarial treatments are urgently needed for drug-resistant malaria infections. Host-directed therapies (HDT) represent an attractive strategy for the devel-opment of new an...

ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 365.1

2022-05-19 | PXD032276 | Pride

Doxycycline as host-directed therapy in pulmonary tuberculosis

Doxycycline as host-directed therapy in pulmonary tuberculosis: a Phase 2 randomized double-blind, placebo-controlled trial

PRJEB38126 | ENA

Gefitinib results in robust host-directed immunity against Salmonella infection through proteo-metabolomic reprogramming.

The rise of antibiotic-resistant strains of Salmonella has demand the development of alternative therapeutic strategies. Recent studies have shown that targeting host factors may provide an alternative approach for the treatment of intracellular pathogens. Host-directed therapy (HDT) modulates host ...

ORGANISM(S): Homo sapiens (Human)

2021-03-26 | PXD024771 | Pride

Salmonella Proteo-metabolomic Dia Swath-ms Thp-1

Repurposing Tamoxifen as Potential Host-Directed Therapeutic For Tuberculosis

PRJNA741500 | ENA

Host-Directed Antiviral Therapy.

Not available

S-EPMC7227448 | biostudies-literature

Genome expression profiling identifies host-directed antimicrobial drugs against respiratory infection by nontypable Haemophilus influenzae

Objectives: Therapies being safe, effective and not vulnerable to develop resistance are highly desirable to counteract bacterial infections. Host-directed therapeutics is an alternative to conventional antibiotics based on perturbing host pathways subverted by pathogens during their life cycle by t...

ORGANISM(S): Homo sapiens

2015-09-23 | E-GEOD-69134 | biostudies-arrayexpress

Targeting Tryptophan Metabolism for Tuberculosis Biomarkers and Host-Directed Therapy.

Not available

S-EPMC12573232 | biostudies-literature

Modulation of innate immunity in airway epithelium for host-directed therapy.

Not available

S-EPMC10213533 | biostudies-literature

Targeting glycolysis reduces infection and dampens inflammation in a host-directed therapy for dengue

PRJNA719071 | ENA

Elimination of senescent cells with senolytic host- directed therapy reduces tuberculosis progression in mice

PRJNA1238808 | ENA

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