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MetabolomicsTaurine ameliorates oxidative stress of BMSCs and promotes osteogenesis in irradiated jaws
Osteoradionecrosis of the jaw (ORNJ) is a complication after head and neck radiotherapy that severely affects patients’ quality of life. Currently, an overall understanding of microenvironmental factors of ORNJ is still lacking. Here, we reveal the activation of taurine metabolism in irradiated mand...
2024-07-08 | MTBLS10284 | MetaboLights
ProteomicsExtracellular vesicles from osteogenic differentiated human BMSCs
Pathological processes like osteoporosis or steroid-induced osteonecrosis of the hip are accompanied by increased bone marrow adipogenesis. Such disorder of adipogenic/osteogenic differentiation, which affects also bone marrow derived mesenchymal stem cells (BMSCs) contributes to bone loss during ag...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD035845 | Pride
Ev Bmsc 
TranscriptomicsLeukemia Cell Lines Induce Changes in Bone Marrow Stromal Cells
Bone marrow derived stromal cells (BMSCs) are a multipotent population that supports angiogenesis, wound healing, immunomodulation and plays an active role in the hematopoietic niche. On the other hand, they are also involved in the nurturing of bone marrow tumors and metastasis, showing a pro-tumor...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-45663 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of primary human bone marrow stromal cells (BMSCs) and telomerase-immortalised single cell derived clonal BMSC lines
Bone marrow stromal cells (BMSCs) provide hematopoietic support, immunoregulation and contain a stem cell fraction capable of skeletogenic differentiation. A heterogeneous population of primary bone marrow BMSCs were isolated from a single human donor (FH181), and a lentiviral expression system was ...
ORGANISM(S): Homo sapiens 
2015-07-23 | E-MTAB-3511 | biostudies-arrayexpress
TranscriptomicsDistinct gene expression patterns of ‘multipotent' versus ‘unipotent' single colony-derived strains (SCDSs) of human bone marrow stromal cells (BMSCs)
Dyskeratosis congenita (DC) is an inherited multi-system disorder, characterized by oral leukoplakia, nail dystrophy, and abnormal skin pigmentation, as well as high rates of bone marrow failure, solid tumors, and other medical problems such as osteopenia. DC and telomere biology disorders (collect...
ORGANISM(S): Homo sapiens 
2015-05-11 | E-GEOD-64789 | biostudies-arrayexpress
ProteomicsNEAT1 Regulates BMSCs Aging Through Disruption of FGF2 Nuclear Transport
Background: The aging of bone marrow mesenchymal stem cells (BMSCs) impairs bone tissue regeneration, contributing to skeletal disorders. LncRNA NEAT1 is considered as a proliferative inhibitory role during cellular senescence, but the relevant mechanisms remain insufficient. This study aims to eluc...
ORGANISM(S): Homo Sapiens 
2025-01-16 | PXD059860 |
TranscriptomicsGene expression profiling on FePro labeled bone marrow stromal cells
Superparamagnetic iron oxide nanoparticles (SPION) are increasingly used to label human bone marrow stromal cells (BMSCs, also called mesenchymal stem cells) to monitor their fate by in vivo MRI and histology after Prussian blue (PB) staining. SPION-labeling appears to be safe as assessed by in vitr...
ORGANISM(S): Homo sapiens 
2011-01-24 | E-GEOD-20431 | biostudies-arrayexpress
GenomicscircRNA expression in BMSCs
circRNA expression in BMSCs
PRJNA474091 | ENA
GenomicsmiRNA expression in BMSCs
miRNA expression in BMSCs
PRJNA474092 | ENA
TranscriptomicsKnockdown of TERC with siRNA in normal bone marrow stromal cells (BMSCs) recapitulates the defective BMSC phenotype in patients with telomere biology disorders
Dyskeratosis congenita (DC) is an inherited multi-system disorder, characterized by oral leukoplakia, nail dystrophy, and abnormal skin pigmentation, as well as high rates of bone marrow failure, solid tumors, and other medical problems such as osteopenia. DC and telomere biology disorders (collect...
ORGANISM(S): Homo sapiens 
2014-12-09 | E-GEOD-64023 | biostudies-arrayexpress
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